Novel particulate vaccine candidates recombinantly produced by pathogenic and nonpathogenic bacterial hosts : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Microbiology at Massey University, Manawatu, New Zealand. [PDF]
, 2017 Polyhydroxyalkanoates (PHAs) are biopolyesters synthesized as small spherical cytoplasmic inclusion bodies by a range of bacteria. Recently, PHA beads have been investigated for use as a vaccine delivery platform by using engineered heterologous ...
Lee, Jason Wong
core
A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish [PDF]
, 2008 Background A large multigene family of NOD-like receptor (NLR) molecules have been described in mammals and implicated in immunity and apoptosis. Little information, however, exists concerning this gene family in non-mammalian taxa.
Kerry J Laing +3 more
core +2 more sources
Activation of the High Mobility Group Box 1/Receptor for Advanced Glycation Endproducts /NOD‐like Receptor Family Pyrin Domain‐Containing 3 Axis Under Chronic Intermittent Hypoxia Induction Promotes the Progression of Atherosclerosis in ApoE −/− Mice [PDF]
, 2023 Haoqu Tan +6 more
openalex +1 more source
Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley +1 more source
Structural and Functional Analysis of the NLRP4 Pyrin Domain
Biochemistry, 2012 NLRP4 is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family of cytosolic receptors and a member of an inflammation signaling cascade. Here, we present the crystal structure of the NLRP4 pyrin domain (PYD) at 2.3 Å resolution.
Eibl, Clarissa +11 more
openaire +3 more sources
Ibrain, EarlyView.Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley +1 more source
Journal of Intelligent Medicine, EarlyView.Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran +5 more
wiley +1 more source
Journal of Dairy Science, 2019 Ketosis is an important metabolic disease that can negatively affect the production efficiency of dairy cows. Earlier studies have revealed metabolic and inflammatory alterations in the blood associated with ketosis; however, a link between ketosis and ...
Taiyu Shen +10 more
semanticscholar +1 more source
AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome [PDF]
, 2016 Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation are associated with several metabolic and inflammatory diseases.
Alcocer-Gómez, Elísabet +5 more
core
Pyrin Q148 mutation and familial Mediterranean fever [PDF]
QJM, 2002 Sir, Familial Mediterranean fever (FMF) is an auto‐inflammatory disease with an autosomal recessive inheritance. Defects in the protein pyrin cause the characteristic attacks of the disease.1,,2 More than 20 mutations have been identified in the gene coding pyrin.
openaire +1 more source