Results 191 to 200 of about 88,038 (326)

Suunnittelijan sydän : Graafisen suunnittelijan arvot työelämässä [PDF]

, 2016
Graafisen suunnittelijan vastuu on yksi alan ikuisuus­kysymyksistä. Onko suunnittelija vastuussa ennen kaikkea itselleen, asiakkaalleen, yleisölleen, yhteisölleen vai ympäristölleen?
Neva, Anna
core  

Impact of combined ginsenoside‐MC1 and irisin on mitochondrial apoptosis in diabetic rats with hepatic reperfusion injury: Role of AMPK/JNK signalling

Experimental Physiology, EarlyView.
Abstract Hepatic ischaemia–reperfusion (IR) injury is a serious clinical issue, especially in patients with type 2 diabetes mellitus (T2DM). As mitochondria play a critical role in the regulation of IR‐induced liver damage, mitochondria‐targeted treatment is of the utmost significance for improving outcomes.
Jie Lin, Lei Han, Zhigang Ma, Bo Yuan, Yabin Yu   +4 more
wiley   +1 more source

Design Principles for Inflammasome Inhibition by Pyrin-Only-Proteins [PDF]

, 2022
Zachary Mazanek, Shuai Wu, Gretchen Belotte, Jeffery J Zhou, Christina M Stallings, Archit Garg, Jacob Lueck, Jungsan Sohn   +7 more
openalex   +1 more source

Differential effect of lead and cadmium on mitochondrial function and NLRP3 inflammasome activation in human trophoblast

The Journal of Physiology, EarlyView.
Abstract figure legend The human placenta not only detects the presence of Pb and Cd but also carries hypoxia and inflammatory risks, which are associated with pregnancy complications. To understand the impact of these factors on the placental trophoblast, we evaluated the effect of Pb and Cd on mitochondrial function and the NLRP3 inflammasome in ...
Yifeng Dai, Xijin Xu, Xia Huo, Joost H. N. Schuitemaker, Marijke M. Faas   +4 more
wiley   +1 more source

Milk Fat Globule Membrane Supplementation Attenuates Cognitive Impairment in APP/PS1 Mice via Suppressing Neuroinflammation in a Gut Microbiota‐Mediated Serum Resolvin D1/Anandamide Manner

Food Frontiers, Volume 7, Issue 2, March 2026.
MFGM modulated gut microbiota accompanied by the increased serum RVD1 and AEA levels, which subsequently regulated the miRNA profile. This modulation alleviated neuroinflammation via suppressing the NLRP3 inflammasome signaling and microglial activation, thereby attenuating AD‐related cognitive impairment both in vivo and in vitro.
Han Gong, Qichen Yuan, Min Du, Xiaohan Liu, Xueying Mao   +4 more
wiley   +1 more source

Lyömäsoittimien orkesteristemmojen harjoittelu koesoittoon [PDF]

, 2014
Opinnäytetyö sisältää harjoitteluohjeita kuuteen eri orkesteristemmaan, joista jokainen on eri lyömäsoittimelle. Sen päämäärä on avata koesoittotehtävien monimuotoisuutta harjoituksina sekä näyttää, mitä kaikkea on hyvä ottaa huomioon harjoitellessa ...
Sakki, Henri
core  

Cardamonin Commands the Colonic Metabolite Columbianetin Acetate to Compete Against LPS in Binding HMGB1 in the Kidney, Preventing Lipopolysaccharide‐Induced Renal Tubular Pyroptosis

Food Frontiers, Volume 7, Issue 2, March 2026.
Cardamonin upregulate sd the intestinal metabolite columbianetin acetate, which competitively bound HMGB1 to prevent LPS‐induced renal tubular cell pyroptosis (the figure is created with BioRender). ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) results in high mortality due to the lack of effective interventions. The current study reports the
Zihui Zhou, Xuechun Sun, Jian Zhou, Huali Meng, Pengfei Fan, Yufeng Chu, Hao Wu   +6 more
wiley   +1 more source

A Type VI Secretion System in Burkholderia Species cenocepacia and orbicola Triggers Distinct Macrophage Death Pathways Independent of the Pyrin Inflammasome [PDF]

, 2023
Nicole A. Loeven, Arianna D. Reuven, Abigail P. McGee, Clarrisa Dabi, Bethany W. Mwaura, James B. Bliska   +5 more
openalex   +1 more source

Jefferson Alumni Bulletin – Volume 57, Number 2, Spring 2008 [PDF]

, 2008
Jefferson Alumni Bulletin – Volume 57, Number 2, Spring 2008 Dean\u27s Column; Page 2 Findings; Page 4 On Campus; Page 8 John H. Moore, Jr., MD, GS\u2784, FACS; Page 10 Out of the Office; Page 12 The Birth and Growth of a Medical School; Page 20 Class ...

core   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source