A Three-Step Route to Functionalized Pyrrole-2,5-Dicarboxylic Acids from Galactaric Acid. [PDF]
ChemSusChemGalactaric acid (GalA) has been used as substrate for a library of N‐substituted pyrrole‐2,5‐dicarboxylic acids (PDCAs). Existing routes to N‐substituted PDCAs require many steps or lack product isolation. We present a simple, scalable three‐step synthesis from GalA via a 2‐pyrone salt, giving isolated PDCA derivatives in high yield without ...
Trapasso G +3 more
europepmc +2 more sources
Antibiotics, 2022 Urinary tract infection (UTI) is one of the most common bacterial infections in the world, which is associated with high morbidity and mortality rates.
Ahmed M. E. Kotb +5 more
doaj +1 more source
Engineering 2-Pyrone-4,6-Dicarboxylic Acid Production Reveals Metabolic Plasticity of Poplar. [PDF]
Plant Biotechnol JABSTRACT Woody biomass is a promising source of fermentable sugars for biofuels and bio‐based chemicals, but its industrial use is limited by the costly biorefinery process. A viable strategy to reduce costs involves enhancing both biomass processability and the generation of high‐value co‐products.
Dwivedi N +7 more
europepmc +2 more sources
Marine Drugs, 2019 Four 4-hydroxy-α-pyrones including three new ones named nipyrones A−C (1−3) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their
Lijian Ding +6 more
doaj +1 more source
Enantiomeric oxidation of organic sulfides by the filamentous fungi Botrytis cinerea, Eutypa lata and Trichoderma viride [PDF]
, 2007 The biotransformations of a series of substituted sulfides were carried out with the filamentous fungi Botrytis cinerea, Eutypa lata and Trichoderma viride.
Annunziata +28 more
core +2 more sources
Total synthesis of aurofusarin: studies on the atropisomeric stability of bis-naphthoquinones [PDF]
, 2018 An efficient annulation involving pyrone addition to a quinone and Dieckmann condensation was developed for rapid assembly of a γ-naphthopyrone monomeric precursor to the bis-naphthoquinone natural product aurofusarin.
Allen +42 more
core +1 more source
Pyrone-based inhibitors of metalloproteinase types 2 and 3 may work as conformation-selective inhibitors. [PDF]
, 2011 Matrix metalloproteinases are zinc-containing enzymes capable of degrading all components of the extracellular matrix. Owing to their role in human disease, matrix metalloproteinase have been the subject of extensive study.
de Oliveira, César AF +2 more
core +1 more source
Biosynthesis of α-pyrones [PDF]
Beilstein Journal of Organic Chemistry, 2016 The α-pyrone moiety is a structural feature found in a huge variety of biologically active metabolites. In recent times new insights into additional biosynthetic mechanisms, yielding in such six-membered unsaturated ester ring residues have been obtained.
openaire +3 more sources
Synthesis and characterization of nickel(II) maltolate complexes containing ancillary bisphosphine ligands [PDF]
, 2011 Cationic nickel(II) complexes containing chelating O,O'-donor maltolate or ethyl maltolate ligands in conjunction with bidentate bisphosphine ligands Ph₂P(CH₂)nPPh₂ were prepared by a one-pot reaction starting from nickel(II) acetate, bisphosphine ...
Alblawi, Jamal +2 more
core +1 more source
Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. [PDF]
, 2011 Based on its capacity to inhibit in vitro HIV-1 replication in T cells and the release of pro-inflammatory cytokines in monocytes, the prenylated heterodimeric phloroglucinyl α-pyrone arzanol was identified as the major anti-inflammatory and anti-viral ...
Appendino G +8 more
core +1 more source