Results 11 to 20 of about 9,191 (227)
Engineering an Acyl-CoA Ligase With Enhanced Activity Toward Synthetic CoA Alternatives. [PDF]
ChembiochemEngineering an acyl‐CoA ligase shifts thiol specificity toward inexpensive synthetic thiols such as N‐acetylcysteamine (SNAC), enabling enzymatic generation of acyl‐SNAC starter units that support polyketide biosynthesis. Fatty acyl‐coenzyme A (CoA) thioesters are indispensable intermediates in primary metabolism and essential building blocks for ...
Cossin JR, Taboada SA, Williams GJ.
europepmc +2 more sources
A Three-Step Route to Functionalized Pyrrole-2,5-Dicarboxylic Acids from Galactaric Acid. [PDF]
ChemSusChemGalactaric acid (GalA) has been used as substrate for a library of N‐substituted pyrrole‐2,5‐dicarboxylic acids (PDCAs). Existing routes to N‐substituted PDCAs require many steps or lack product isolation. We present a simple, scalable three‐step synthesis from GalA via a 2‐pyrone salt, giving isolated PDCA derivatives in high yield without ...
Trapasso G +3 more
europepmc +2 more sources
Two new α-pyrone-containing polyketides isolated from the fungus Aspergillus aureoterreus
, 2022 Two undescribed α-pyrone-containing polyketide derivatives designated aurovertins V (1) and W (2), and a known analogue (3), were isolated from the fungus Aspergillus aureoterreus.
Beiping Zhou (12406809) +3 more
core +1 more source
A Short Synthesis of Delavatine A Unveils New Insights into Site-Selective Cross-Coupling of 3,5-Dibromo-2-pyrone [PDF]
, 2019 The recognition of latent symmetry in delavatine A has enabled a short synthesis of the natural product starting from 3,5-dibromo-2-pyrone. The concise synthetic route features a cascade process involving a 6π electrocyclization to construct the indane ...
Kevlishvili, Ilia +14 more
core +1 more source
Biosynthesis of α-pyrones [PDF]
Beilstein Journal of Organic Chemistry, 2016 The α-pyrone moiety is a structural feature found in a huge variety of biologically active metabolites. In recent times new insights into additional biosynthetic mechanisms, yielding in such six-membered unsaturated ester ring residues have been obtained.
openaire +3 more sources
, 2021 Cyclocurcumin, a turmeric curcuminoid with potential therapeutic properties, is also a natural photoswitch that may undergo E/Z photoisomerization under UV light. In order to be further exploited in relevant biological applications, photoactivation under
Stephane, Parant +5 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2009 Pd/C-mediated alkynylation of 5-iodo-pyrazole-4-carboxylic acid, involving the first regioselective construction of α-pyrone ring on a pyrazol moiety via tandem coupling–cyclization process, has been developed to afford pyrano[4,3-c]pyrazol-4(1H)-one in ...
Dhilli Rao Gorja +3 more
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Molecules, 2021 This review gives an up-to-date overview of the different ways (routes) to the synthesis of coumarin(benzopyrone)-fused, five-membered aromatic heterocycles with one heteroatom, built on the pyrone moiety. Covering 1966 to 2020.
Eslam Reda El-Sawy +2 more
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5-Hydroxy-2-methyl-4H-pyran-4-one
Acta Crystallographica Section E, 2009 The title compound, C6H6O3, is a member of the pyrone family. The molecules are planar (r.m.s. deviation of the asymmetric unit is 0.0248 Å, whereas that of the dimer is 0.0360 Å) and they are dimerized due to intermolecular O—
Bernhard K. Keppler +4 more
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Nocapyrones: α- and γ-Pyrones from a Marine-Derived Nocardiopsis sp.
Marine Drugs, 2014 One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2–4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment.
Youngju Kim +7 more
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