The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury [PDF]
, 2018 Acute exposure to ionizing radiation induces massive cell death and severe damage to tissues containing actively proliferating cells, including bone marrow and the gastrointestinal tract.
Cetinbas, Naniye +15 more
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ROS induced pyroptosis in inflammatory disease and cancer
Frontiers in ImmunologyPyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various
Jingsong Wang +5 more
doaj +1 more source
インフルエンザウイルス感染抑制に関与する気道上皮由来インフラマソーム活性化機構の解析 [PDF]
, 2018 筑波大学University of Tsukuba博士（人間生物学）Doctor of Philosophy in Human Biology2018この博士論文は、全文公表に適さないやむを得ない事由があり要約のみを公表していましたが、解消したため、令和３(2021)年1月18日に全文を公表しました ...
202871, LEE, SangJoon
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O-GlcNAcylation dictates pyroptosis
Frontiers in ImmunologyO-GlcNAcylation is a dynamic post-translational modification involving the attachment of N-acetylglucosamine to serine and threonine residues. This review emphasizes its role in regulating the signaling pathways of pyroptosis. Specifically, the O-GlcNAcylation of GSDMD is linked to the modulation of pyroptosis, suggesting that enhancing O-GlcNAcylation
Yue Lang +4 more
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Polyhexamethylene Biguanide and Nadifloxacin Self-Assembled Nanoparticles: Antimicrobial Effects against Intracellular Methicillin-Resistant Staphylococcus aureus [PDF]
, 2018 The treatment of skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA) remains a challenge, partly due to localization of the bacteria inside the host’s cells, where antimicrobial penetration and efficacy is limited.
Chivu, A +3 more
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Modulation of the unfolded protein response by tauroursodeoxycholic acid counteracts apoptotic cell death and fibrosis in a mouse model for secondary biliary liver fibrosis [PDF]
, 2017 The role of endoplasmic reticulum stress and the unfolded protein response (UPR) in cholestatic liver disease and fibrosis is not fully unraveled. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has been shown to reduce endoplasmic reticulum (
Bogaerts, Eliene +9 more
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SGLT2 inhibition attenuates diabetic tubulopathy by suppressing SGK1-mediated pyroptosis
Frontiers in EndocrinologyBackgroundDiabetic tubulopathy is increasingly recognized as a pivotal contributor to diabetic kidney disease (DKD) progression. Excessive pyroptosis of renal tubular epithelial cells exacerbates inflammation and tissue injury.
Xu Shi +20 more
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Triggering Pyroptosis in Cancer
BiomoleculesPyroptosis is an inflammatory programmed cell death recently identified as a crucial cellular process in various diseases, including cancers. Unlike other forms of cell death, canonical pyroptosis involves the specific cleavage of gasdermin by caspase-1, resulting in cell membrane damage and the release of the pro-inflammatory cytokines IL-1β and IL-18.
Daniel E. Johnson, Zhibin Cui
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Pyroptosis in Antiviral Immunity
, 2019 Pyroptosis is a form of lytic, programmed cell death that functions as an innate immune effector mechanism to facilitate host defense against pathogenic microorganisms, including viruses. This type of proinflammatory cell death is orchestrated by proteolytic activation of human or mouse caspase-1, mouse caspase-11 and human caspase-4 and caspase-5 in ...
Teneema, Kuriakose +1 more
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Embryo‐Derived Cathepsin B Promotes Implantation and Decidualization by Activating Pyroptosis
Advanced ScienceEmbryo implantation and decidualization are crucial for a successful pregnancy. How the inflammatory response is regulated during these processes is undefined. Pyroptosis is an inflammatory form of cell death mediated by gasdermin D (GSDMD).
Meng‐Yuan Li +7 more
doaj +1 more source