Results 131 to 140 of about 82,547 (381)

Relationship between intact HIV-1 proviruses in circulating CD4+ T cells and rebound viruses emerging during treatment interruption. [PDF]

, 2018
Combination antiretroviral therapy controls but does not cure HIV-1 infection because a small fraction of cells harbor latent viruses that can produce rebound viremia when therapy is interrupted. The circulating latent virus reservoir has been documented
Barton, John, Caskey, Marina, Cohen, Yehuda Z, Cohn, Lillian B, Gruell, Henning, Jankovic, Mila, Klein, Florian, Lorenzi, Julio CC, Lu, Ching-Lan, Mendoza, Pilar, Nogueira, Lilian, Nussenzweig, Michel C, Oliveira, Thiago Y, Pai, Joy A   +13 more
core   +1 more source

Pyroptosis in Antiviral Immunity

, 2019
Pyroptosis is a form of lytic, programmed cell death that functions as an innate immune effector mechanism to facilitate host defense against pathogenic microorganisms, including viruses. This type of proinflammatory cell death is orchestrated by proteolytic activation of human or mouse caspase-1, mouse caspase-11 and human caspase-4 and caspase-5 in ...
Thirumala-Devi Kanneganti, Teneema Kuriakose   +1 more
openaire   +3 more sources

Role of pyroptosis in cardiovascular disease [PDF]

Cell Proliferation, 2018
AbstractCardiac function is determined by the dynamic equilibrium of various cell types and the extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially atherosclerosis and myocardial infarction, are often accompanied by cell death and acute/chronic inflammatory reactions. Caspase‐dependent pyroptosis is characterized by
Zeng Zhaolin, Li Guohua, Wu Shiyuan, Wang Zuo   +3 more
openaire   +3 more sources

Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P

Cell Research, 2023
Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear.
Yuan-Li Ai, Wei-jia Wang, F. Liu, Wei Fang, Hang-zi Chen, Liu-zheng Wu, Xuehui Hong, Yuekun Zhu, Cixiong Zhang, Long-Yu Liu, Wendy Hong, Bo Zhou, Qi-tao Chen, Qiao Wu   +13 more
semanticscholar   +1 more source

Cold Atmospheric Plasma Selectively Disrupts Breast Cancer Growth in a Bioprinted 3D Tumor‐Stroma Co‐Culture Model

Advanced Healthcare Materials, EarlyView.
This research introduces a cold plasma‐based platform for treating breast cancer bone metastases. Using a novel bioprinted 3D tumor‐stroma model, it highlights the selective antitumor effects of plasma‐generated reactive species. The platform aims to advance non‐invasive therapeutic strategies, offering potential clinical applications in controlling ...
Laura M. Bouret, Jean‐Baptiste Billeau, Michael H. Weber, Derek H. Rosenzweig, Stephan Reuter   +4 more
wiley   +1 more source

Actin polymerization as a key innate immune effector mechanism to control Salmonella infection. [PDF]

, 2014
Salmonellosis is one of the leading causes of food poisoning worldwide. Controlling bacterial burden is essential to surviving infection. Nucleotide-binding oligomerization domain-like receptors (NLRs), such as NLRC4, induce inflammasome effector ...
Achouri, Sarra, Bryant, Clare E, Cammarota, Eugenia, Cicuta, Pietro, Ekpenyong, Andrew, Guck, Jochen R, Hughes, Katherine, Man, Si Ming, Ng, Gilbert, Rizzo, Alessandro, Tourlomousis, Panagiotis, Wright, John A   +11 more
core   +1 more source

Guides for Developing Hundreds of Novel Chiral MXenes and MBenes Nanosheets/Quantum Dots for Next‐Generation Chiral Engineered Biomaterials Applications

Advanced Healthcare Materials, EarlyView.
The emerging field of MXene/MBene materials has progressed rapidly, advancing diverse research fields, including biomedical engineering, biomedicine, agriculture, and the environment. This nanobiotechnology can tackle longstanding challenges in these areas.
Alireza Rafieerad, Ahmad Amiri
wiley   +1 more source

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death [PDF]

, 2016
Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β.
Alix, E, Birrell, M, Holden, D, Jennings, E, Matthews, S, Shao, F, Shenoy, A, Thurston, T   +7 more
core   +1 more source

Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead‐Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.)

Advanced Science, EarlyView.
This study reveals that Lead reprograms glucose metabolism to enhance H3K18la, driving DRP1‐dependent mitochondrial DNA leakage and cGAS‐STING‐mediated pyroptosis. Melatonin targets G6PD to suppress glycolysis‐driven H3K18la and restore mitochondrial homeostasis, thereby alleviating Lead‐induced liver injury in common carp through disruption of the ...
Zhiying Miao, Xiaofeng Ji, Lai Wei, Zhiruo Miao, Shiwen Xu   +4 more
wiley   +1 more source

Molecular Mechanisms Used by Salmonella to Evade the Immune System [PDF]

, 2017
Human and animal pathogens are able to circumvent, at least temporarily, the sophisticated immune defenses of their hosts. Several serovars of the Gram-negative bacterium Salmonella enterica have been used as models for the study of pathogen-host ...
Bernal Bayard, Joaquín, Ramos Morales, Francisco   +1 more
core   +1 more source