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Pyroptosis and pyroptosis-inducing cancer drugs
Acta Pharmacologica Sinica, 2022Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals, cells undergo inflammasome assembly, GSDM cleavage, the release of proinflammatory cytokines and other cellular contents, eventually leading to inflammatory cell death.
Fan, Yang +4 more
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Pyroptosis in diabetic nephropathy
Clinica Chimica Acta, 2021Diabetic nephropathy (DN), a sterile inflammatory disease, is a serious complication of diabetes mellitus. However, recent evidence indicates that pyroptosis, a new term for pro-inflammatory cell death featured by gasdermin D (GSDMD)-stimulated plasma membrane pore generation, cell expansion and rapid lysis with the extensive secretion of pro ...
Abdullah, Al Mamun +8 more
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Coral gasdermin triggers pyroptosis
Science Immunology, 2020Coral gasdermin is activated by caspase 3 and involved in pathogen-induced coral death.
Shuai Jiang +4 more
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Molecular Mechanisms of Pyroptosis
2023Pyroptosis is a regulated form of cell death that leads to inflammation and plays a role in many different diseases. Pyroptosis was initially defined by the dependence on caspase-1, a protease which is activated by innate immune signaling complexes called inflammasomes.
Marisa J, Anderson +2 more
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Bioorthogonal Disruption of Pyroptosis Checkpoint for High-Efficiency Pyroptosis Cancer Therapy
Journal of the American Chemical Society, 2023Pyroptosis is an inflammatory form of programmed cell death that holds great promise in cancer therapy. However, autophagy as the crucial pyroptosis checkpoint and the self-protective mechanism of cancer cells significantly weakens the therapeutic efficiency. Here, a bioorthogonal pyroptosis nanoregulator is constructed to induce pyroptosis and disrupt
Wenting Zhang +7 more
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New prospects of cancer therapy based on pyroptosis and pyroptosis inducers
Apoptosis, 2023Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules. Pyroptosis is closely associated with various malignant tumors. Recent studies have demonstrated that pyroptosis can either inhibit or promote the development of malignant tumors, depending on the cell ...
Qiaoyun, Chen +3 more
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Pyroptosis heats tumour immunity
Nature Reviews Immunology, 2020Two studies published in Nature report that gasdermin-mediated pyroptosis of tumour cells induces cytotoxic lymphocyte-mediated antitumour immune responses.
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Epithelial Pyroptosis in Host Defense
Journal of Molecular Biology, 2022Pyroptosis is a lytic form of cell death that is executed by a family of pore-forming proteins called gasdermins (GSDMs). GSDMs are activated upon proteolysis by host proteases including the proinflammatory caspases downstream of inflammasome activation.
Madeline J. Churchill +2 more
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Inflammasome-independent pyroptosis
Current Opinion in ImmunologyGasdermins are membrane pore-forming proteins that cause pyroptosis, an inflammatory cell death in which cells burst and release cytokines, chemokines, and other host alarm signals, such as ATP and HMGB1, which recruit and activate immune cells at sites of infection and danger. There are five gasdermins in humans - gasdermins A to E.
Xing, Liu, Judy, Lieberman
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PYROPTOSIS and THE MECHANISM OF PYROPTOSIS
2023Hücresel inflamatuar nekrozolarak da bilinen piroptoz, programlanmış hücre ölümünün yeni bir şeklidir. İlkolarak 1992'de Gram negatif bakterilerle enfekte olmuş makrofajlarda tanımlananpiroptozis daha sonra çeşitli bağışıklık hücrelerinde de bildirilmiştir.
Gezer, Arzu, Karadağ Sarı, Ebru
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