Results 81 to 90 of about 77,046 (386)

Inhibition of macrophage pyroptosis ameliorates silica-induced pulmonary fibrosis

Ecotoxicology and Environmental Safety, 2023
Macrophage pyroptosis has recently been involved in some inflammatory and fibrosis diseases, however, the role of macrophage pyroptosis in silica-induced pulmonary fibrosis has not been fully elucidated.
Fuyang Jiang, Qiyue Jiang, Lin Hou, Jing Zhao, Zhonghui Zhu, Qiyue Jia, Wenming Xue, Hongwei Wang, Yan Wang, Lin Tian   +9 more
doaj  

The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases

Cell Death Discovery, 2022
Pyroptosis is a controlled form of inflammatory cell death characterized by inflammasome activation, pore formation, and cell lysis. According to different caspases, pyroptosis can be divided into canonical, non-canonical, and other pathways. The role of
Siyu Wang, Hua Wang, Chengyao Feng, Chenbei Li, Zhihong Li, Jieyu He, Chao Tu   +6 more
doaj   +1 more source

Pyroptosis as a candidate therapeutic target for Alzheimer’s disease

Frontiers in Aging Neuroscience, 2022
Pyroptosis is a form of cell death mediated by inflammasomes and gasdermins, and the relevance of pyroptosis to neurodegenerative diseases is currently receiving increasing attention.
Yuehua Huang, Yuehua Huang, Xiaoyu Li, Guifei Luo, Guifei Luo, Junli Wang, Junli Wang, Ranhui Li, Chuyi Zhou, Teng Wan, Fenglian Yang   +10 more
doaj   +1 more source

Cytoprotective Activated Protein C Averts Nlrp3 Inflammasome–Induced Ischemia-Reperfusion Injury Via Mtorc1 Inhibition [PDF]

, 2017
Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is associated with apoptosis inhibition. However, IRI is hallmarked by inflammation, and hence, cell-death forms disjunct from immunologically silent apoptosis are, in ...
Al-Dabet, Moh\u27d Mohanad, Bock, Fabian, Braun-Dullaeus, Ruediger C., Camerer, Eric, Dockendorff, Chris, Elwakiel, Ahmed, Esmon, Charles T., Gadi, Ihsan, Ghosh, Sanchita, Griffin, John H., Huber, Tobias B., Isermann, Berend, Kohli, Shrey, Manoharan, Jayakumar, Nazir, Sumra, Ranjan, Satish, Shahzad, Khurrum   +16 more
core   +2 more sources

Pyroptosis in health and disease: mechanisms, regulation and clinical perspective

Signal Transduction and Targeted Therapy
Pyroptosis is a type of programmed cell death characterized by cell swelling and osmotic lysis, resulting in cytomembrane rupture and release of immunostimulatory components, which play a role in several pathological processes.
Yifan Liu, Renjie Pan, Yuzhen Ouyang, Wan-Yi Gu, Tengfei Xiao, Hongmin Yang, Ling Tang, Hui Wang, Bo Xiang, Pan Chen   +9 more
semanticscholar   +1 more source

mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy

Nature Communications, 2023
Synergistically improving T-cell responsiveness is promising for favorable therapeutic outcomes in immunologically cold tumors, yet current treatments often fail to induce a cascade of cancer-immunity cycle for effective antitumor immunity.
Fengqiao Li, Xue-Qing Zhang, William Ho, Maoping Tang, Zhongyu Li, Lei Bu, Xiaoyang Xu   +6 more
semanticscholar   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Modulation of the unfolded protein response by tauroursodeoxycholic acid counteracts apoptotic cell death and fibrosis in a mouse model for secondary biliary liver fibrosis [PDF]

, 2017
The role of endoplasmic reticulum stress and the unfolded protein response (UPR) in cholestatic liver disease and fibrosis is not fully unraveled. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has been shown to reduce endoplasmic reticulum (
Bogaerts, Eliene, Colle, Isabelle, Devisscher, Lindsey, Geerts, Anja, Hoorens, Anne, Paridaens, Annelies, Raevens, Sarah, van Grunsven, Leo, Van Vlierberghe, Hans, Verhelst, Xavier   +9 more
core   +2 more sources

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in diabetic retinopathy

Frontiers in Immunology, 2023
In the working-age population worldwide, diabetic retinopathy (DR), a prevalent complication of diabetes, is the main cause of vision impairment. Chronic low-grade inflammation plays an essential role in DR development.
Xiaoqin Zheng, Jia Wan, Gang Tan
semanticscholar   +1 more source

Pyroptosis and Oral Cancer

The Journal of Contemporary Dental Practice, 2019
Cell death is a basic biological occurrence which is required for the existence and growth of an organism.1 Programmed cell death sustains tissue homeostasis facilitating the elimination of redundant cells.2 When an infectious disease sets in, cells that have been infected by pathogens prove harmful to the host eclls.2 Evidence has proved that cell ...
Gargi S Sarode, Namrata Sengupta, Shankargouda Patil, Sachin C Sarode, Piyush Jain   +4 more
openaire   +2 more sources