Results 211 to 220 of about 81,237 (352)

Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry

ChemistryOpen, Volume 15, Issue 1, January 2026.
Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten, Raushan Koizhaiganova, Dilnaz Bissenbay, Bagila Tursynova, Zhanar Zhaxibayeva, Valentina Yu   +5 more
wiley   +1 more source

Automated parametrization of small molecules within the Martini 3 coarse-grained model guided by experimental log P values. [PDF]

Sci Rep
Kelidou M, Stroh KS, Risselada HJ.
europepmc   +1 more source

Crystal structure of fatty acid thioesterase A bound by 129 fragments provides diverse development opportunities

Pest Management Science, Volume 82, Issue 1, Page 151-168, January 2026.
Crystallographic fragment screening of A. thaliana FatA yielded 141 hits and along with orthogonal assays, this enables the target for rapid development of novel chemical matter to the currently available herbicides. Abstract BACKGROUND In order to alleviate the growing issue of herbicide resistance, diversification of the herbicide portfolio is ...
Ekaterina Kot, Matteo Paolo Ferla, Patricia Helen Hollinshead, Charles William Ernest Tomlinson, Daren Fearon, Jasmin Cara Aschenbrenner, Lizbé Koekemoer, Max Winokan, Michael Fairhead, Xiaomin Ni, Rod Chalk, Katherine Sara England, Laura Ortega Varga, Mark Greer Montgomery, Nicholas Phillip Mulholland, Frank von Delft   +15 more
wiley   +1 more source

Prolintane analogs as hybrid monoamine transporter ligands: Structural determinants and species differences. [PDF]

J Biol Chem
Kastner N, Islam MN, Dybek M, Roth E, Heisinger S, Holy M, Jäntsch K, Walther D, Stockner T, Baumann MH, Brandt SD, Wallach J, Sitte HH, Kudlacek O.   +13 more
europepmc   +1 more source

Ethyl 3′-cyano-1′-methyl-2-oxo-4′-phenylspiro[acenaphthene-1,2′-pyrrolidine]-3′-carboxylate [PDF]

, 2008
Wenlong Yang, Zheng-Quan Zuo, Ming Li
openalex   +1 more source

From Molecular Bricks to Sustainable Nanomaterials: An Accurate and Scalable Unsupervised Workflow

Small Structures, Volume 7, Issue 1, January 2026.
An adaptive accuracy framework integrates Pisa Composite Schemes with the Nano‐LEGO platform for data‐driven molecular design. Molecular fragments validated through explicitly correlated and bond‐corrected DFT models enable scalable prediction of structural and spectroscopic properties.
Federico Lazzari, Luigi Crisci, Vincenzo Barone   +2 more
wiley   +1 more source

Retraction notice to "Pyrrolidine derivatives as α-amylase and α-glucosidase inhibitors: Design, synthesis, structure-activity relationship (SAR), docking studies and HSA binding" [Heliyon 10 (2024) e39444]. [PDF]

Heliyon
Bhat AA, Tandon N, Singh I.
europepmc   +1 more source

An efficient strategy for the synthesis of polysubstituted chromeno[4,3-b]pyrrolidine derivatives

, 2014
Li Tian, Guo‐Qiang Xu, Yun‐Han Li, Yong‐Min Liang, Peng‐Fei Xu   +4 more
openalex   +2 more sources

The synthesis of polyfluoroalkyl substituted pyrroles as building blocks for obtaining fluorinated pyrrolidine-containing alkaloids

, 2020
Anton A. Klipkov, Alexander E. Sorochinsky, Karen V. Tarasenko, Igor I. Gerus   +3 more
openalex   +2 more sources

Paradoxical mitochondrial effects of nitric oxide synthase inhibition following oxygen–glucose deprivation–reoxygenation (OGD/R) in endothelial cells and neurons

British Journal of Pharmacology, Volume 183, Issue 2, Page 349-363, January 2026.
Background and Purpose Current dogma in stroke is that neuronal nitric oxide synthase (NOS1) exacerbates ischaemic brain injury, while endothelial nitric oxide synthase (NOS3) is protective. However, oxidative stress from ischaemia–reperfusion and oxygen–glucose deprivation‐reoxygenation (OGD/R) is known to uncouple NOS, leading to increased production
Venkata N. Sure, Siva S. V. P. Sakamuri, Lokanatha Orgunati, Raed Ageeli, Walter L. Murfee, Prasad V. G. Katakam   +5 more
wiley   +1 more source