Results 331 to 340 of about 70,546 (390)

Synthesis of Spiro[oxindole-3,2'-pyrrolidine] Derivatives from Benzynes and Azomethine Ylides through 1,3-Dipolar Cycloaddition Reactions.

Journal of Organic Chemistry, 2018
A novel synthetic strategy employing benzyne and azomethine ylides for the construction of spiro[oxindole-3,2'-pyrrolidine] derivatives has been achieved in good yields.
Heesun Ryu, J. Seo, H. Ko
semanticscholar   +1 more source

Photochemical In-Flow Synthesis of 2,4-Methanopyrrolidines: Pyrrolidine Analogues with Improved Water Solubility and Reduced Lipophilicity.

Journal of Organic Chemistry, 2018
A practical synthesis of 2,4-methanopyrrolidines was elaborated. The key synthetic step was an intramolecular photochemical [2 + 2]-cycloaddition of an acrylic acid derivative in flow.
Vadym V. Levterov, Oleg M. Michurin, Petro O. Borysko, S. Zozulya, I. Sadkova, A. Tolmachev, Pavel K. Mykhailiuk   +6 more
semanticscholar   +1 more source

Telescoped Synthesis of Stereodefined Pyrrolidines

Organic Letters, 2013
Telescoped and one-pot olefination/asymmetric functionalization approaches to disubstituted pyrrolidines (dr up to 99:1, up to 99% ee) have been developed using commercially available tetramisole (0.1 to 5 mol %). Using OTMS-quinidine as the Lewis base gives preferential access to an anti-configured pyrrolidine in high enantioselectivity.
Dorine Belmessieri, David B. Cordes, Alexandra M. Z. Slawin, Andrew D. Smith   +3 more
openaire   +3 more sources

Asymmetric [3 + 2] Cycloaddition of 3-Amino Oxindole-Based Azomethine Ylides and α,β-Enones with Divergent Diastereocontrol on the Spiro[pyrrolidine-oxindoles].

Organic Letters, 2017
A general and practical organocatalytic asymmetric 1,3-dipolar cycloaddition of 3-amino oxindole-based azomethine ylides and α,β-enones has been developed.
Guodong Zhu, Qian Wei, Hongbo Chen, Yanpeng Zhang, Wen-Chang Shen, Jingping Qu, Baomin Wang   +6 more
semanticscholar   +1 more source

Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids

, 2003
The spiro[pyrrolidine-3,3′-oxindole] ring system is found at the core of a number of alkaloids, which possess significant biological activity and are interesting, challenging targets for chemical synthesis.
C. Marti, E. Carreira
semanticscholar   +1 more source

Facile one-pot synthesis of spirooxindole-pyrrolidine derivatives and their antimicrobial and acetylcholinesterase inhibitory activities

, 2018
A library of novel spirooxindole-pyrrolidine derivatives were facilely synthesized via 1,3-dipolar cycloaddition of azomethine ylide generated from sarcosine and paraformaldehyde with various 3-methyleneoxindolines. The relative configuration of obtained
Ying-Hui Huang, W. Min, Qiulin Wu, Jing Sun, D. Shi, Chaoguo Yan   +5 more
semanticscholar   +1 more source

The microwave spectrum of pyrrolidine

Journal of Molecular Spectroscopy, 1984
Abstract The rotational spectra of the normal and N-D isotopic species of pyrrolidine have been measured. The molecule exists in an envelope conformation, with the nitrogen atom out of the plane containing the carbon atoms and with the imino hydrogen in the axial position.
Heinz Oberhammer, C.H. Gomez, Roberto R. Filgueira, G. Pfafferott, Walther Caminati   +4 more
openaire   +2 more sources

Thermodynamic Study for Gas Absorption in Choline-2-pyrrolidine-carboxylic Acid + Polyethylene Glycol

, 2016
The solubility of pure CO2, CH4, and N2 in the mixture of choline-2-pyrrolidine carboxylic acid ([Cho][Pro]) and polyethylene glycol (PEG200) (mass ratio = 1:2) was measured experimentally at temperatures from 308.15 to 338.15 K and pressures up to 28 ...
Yifeng Chen, Yingying Zhang, Shengjuan Yuan, Xiaoyan Ji, Chang Liu, Zhu-hong Yang, Xiaohua Lu   +6 more
semanticscholar   +1 more source

3-(2-Azidoethyl)oxindoles: Advanced Building Blocks for One-Pot Assembly of Spiro[pyrrolidine-3,3'-oxindoles].

Journal of Organic Chemistry, 2017
A new synthetic approach to biologically relevant spiro[pyrrolidine-3,3'-oxindoles] was developed on the basis of the cascade transformation of 3-(2-azidoethyl)oxindoles via Staudinger/aza-Wittig/Mannich reactions.
A. A. Akaev, Elena V. Villemson, N. Vorobyeva, A. Majouga, E. Budynina, M. Melnikov   +5 more
semanticscholar   +1 more source

New functionalized pyrrolidines

Russian Journal of Organic Chemistry, 2017
New functionalized pyrrolidines have been synthesized from accessible amino acids by the [C+NC+CC]-coupling reaction.
M. F. Abdullin, Mansur S. Miftakhov, V. A. Egorov, A. M. Galeeva, Fanuza A. Gimalova, L. S. Khasanova   +5 more
openaire   +2 more sources