Results 141 to 150 of about 36,836 (288)

A combined experimental and theoretical investigation of the stereoselectivity in the synthesis of azahetrocyclic phosphonates [PDF]

, 2008
Since the discovery of the biological activity of aminoalkylphosphonates, e.g. as enzyme inhibitors, many researchers have focused their attention on conformationally constrained azaheterocyclic phosphonates. Stereocontrol is of major interest during the
Claeys, Diederica, Moonen, Kristof, Roman, Bart, Stevens, Christian, Van Speybroeck, Veronique, Waroquier, Michel   +5 more
core   +1 more source

A modular and divergent approach to spirocyclic pyrrolidines

, 2020
Benjamin D. A. Shennan, P. W. Smith, Yusuke Ogura, Darren J. Dixon   +3 more
openalex   +2 more sources

Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
The combination of bicyclic monoterpene‐ and pyrrolidine‐alkaloid fragments yields novel pseudo‐natural products. Biological characterization revealed that these iDegs are inhibitors and degraders of indoleamine‐2,3‐dioxygenase. Abstract Terpenoid alkaloids are derived from the fusion of structurally diverse terpenoid‐ and alkaloid moieties.
Xiu‐Fen Cheng, Belén Lucas, Philipp Lampe, Stefano Ugel, Suyuan Chen, Anke Unger, Matthias Bischoff, Soheila Rezaei Adariani, Kesava Reddy Naredla, Kamal Kumar, Annika Schmidt, Carsten Strohmann, Petra Janning, Raphael Gasper, María Lucas, Malte Gersch, Sonja Sievers, Vincenzo Bronte, Slava Ziegler, Herbert Waldmann   +19 more
wiley   +2 more sources

Metalloamination/Cyclization of Zinc(II) Amides Derived from N,N-Dimethylhydrazinoalkenes—Applications for the Direct C-SP² Functionalization of Aryl and Vinyl Electrophiles

Inorganics
Treatment of N,N-dimethylhydrazinoalkenes with diethylzinc followed by exposure of the resulting ethylzinc amides to high vacuum drives a Schlenck redistribution metalloamination/cyclization to generate the corresponding bis(organozinc) intermediates in ...
Jérome Lépeule, Christian Frabitore, Tom Livinghouse   +2 more
doaj   +1 more source

Synthesis of fused tetrazolo iminosugars from azido monosaccharide derivatives [PDF]

, 2014
Synthesis of fused tetrazolo iminosugars from azido monosaccharide derivativesUniversidad de Málaga.
Pino-Gonzalez, Maria Soledad
core  

A COLOR TEST FOR CERTAIN PIPERIDINE AND PYRROLIDINE ALKALOIDS [PDF]

, 1960
D. J. McCaldin
openalex   +1 more source

Palladium‐Catalyzed [3+2] Cycloadditions of Alkylidenecyclopropanes to Imines: A Direct Approach to Pyrrolidine Scaffolds

ChemistryEurope
Alkylidenecyclopropanes (ACPs) can work as versatile 3 C partners in a range of [3+n] cycloadditions with unsaturated carbon partners. We now demonstrate that they can also be harnessed for inter‐ and intramolecular palladium‐catalyzed [3+2] formal ...
Ricardo Rodiño, Felipe Verdugo, José L. Mascareñas, Fernando López   +3 more
doaj   +1 more source

Inhibition of nuclear factor-κB activation by pyrrolidine dithiocarbamate prevents chronic FK506 nephropathy [PDF]

, 2003
Satoshi Tamada, Tatsuya Nakatani, Toshihiro Asai, Koichiro Tashiro, Toshiyuki Komiya, Tomohiko Sumi, Mikio Okamura, Shokei Kim, Hiroshi Iwao, Taketoshi Kishimoto, Shinya Yamanaka, Katsuyuki Miura   +11 more
openalex   +1 more source

Piperidines from acid-catalysed cyclisations: Pitfalls, solutions and a new ring contraction to pyrrolidines [PDF]

, 2017
Aldmairi, Abdu H., Dupauw, Alexis, Griffiths-Jones, Charlotte, Henderson, Laura, Knight, David   +4 more
core   +2 more sources

Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure [PDF]

Chloe C. Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller, Amit Sharma, Eamon Comer, Stuart L. Schreiber, Bruno Melillo, L. David Sibley, Arnab K. Chatterjee   +11 more
openalex   +1 more source