Results 71 to 80 of about 17,768 (339)

Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors

Beilstein Journal of Organic Chemistry, 2012
A small set of nojirimycin- and pyrrolidine-based iminosugar derivatives has been synthesized and evaluated as potential inhibitors of porcine and insect trehalases.
Davide Bini, Francesca Cardona, Matilde Forcella, Camilla Parmeggiani, Paolo Parenti, Francesco Nicotra, Laura Cipolla   +6 more
doaj   +1 more source

Azetidine, pyrrolidine and hexamethyleneimine at 170 K [PDF]

Acta Crystallographica Section C Crystal Structure Communications, 2008
The crystal structures of the cyclic amines azetidine (C(3)H(7)N), pyrrolidine (C(4)H(9)N) and hexamethyleneimine (homopiperidine, C(6)H(13)N), of the series (CH(2))(n)NH, with n = 3, 4 and 6, respectively, have been determined at 170 K, following in situ crystallization from the melt.
Bond, A. D., Davies, J. E., Parsons, S.
openaire   +5 more sources

Developing Quasi‐Solid‐State Ether‐Based Electrolytes with Trifluorotoluylation Ionic Liquids for High Voltage Lithium Metal Batteries

Advanced Materials, EarlyView.
This study proposes molecular design strategies to develop trifluorotoluylation ILs that enable quasi‐solid‐state ether‐based electrolytes for high‐voltage LMBs. The designed ILs greatly enhance the oxidative stability of the electrolyte and effectively suppress the dissolution of transition metal ions, facilitating the formation of a LiF‐rich ...
Jin Li, Junjie Chen, Xiaosa Xu, Jiadong Shen, Zhenyu Wang, Zixiao Guo, Pengzhu Lin, Jing Sun, Baoling Huang, Tianshou Zhao   +9 more
wiley   +1 more source

Transaminase‐Triggered Cascades for the Synthesis and Dynamic Kinetic Resolution of Chiral N‐Heterocycles

Angewandte Chemie, EarlyView.
A single‐step biocatalytic route to complex indolizidine and quinolizidine alkaloids is described that relies on transaminase‐triggered double intramolecular aza‐Michael methodology. In one case, a retro‐double intramolecular aza‐Michael reaction enables dynamic kinetic resolution. Abstract Biocatalysis is now a well‐established branch of catalysis and
Adam O'Connell, Marianne B. Haarr, James Ryan, Xingxing Xu, Aoife Martin, Simon N. Smith, Nadia Elghobashi‐Meinhardt, Patricia Fleming, Beatriz Maciá, Vittorio Caprio, Elaine O'Reilly   +10 more
wiley   +2 more sources

Palladium‐Catalyzed [3+2] Cycloadditions of Alkylidenecyclopropanes to Imines: A Direct Approach to Pyrrolidine Scaffolds

ChemistryEurope
Alkylidenecyclopropanes (ACPs) can work as versatile 3 C partners in a range of [3+n] cycloadditions with unsaturated carbon partners. We now demonstrate that they can also be harnessed for inter‐ and intramolecular palladium‐catalyzed [3+2] formal ...
Ricardo Rodiño, Felipe Verdugo, José L. Mascareñas, Fernando López   +3 more
doaj   +2 more sources

Copper(I)-Catalyzed Cross-Coupling of 1-Bromoalkynes with N-Heterocyclic Organozinc Reagents

Molecules, 2022
Nitrogen-containing heterocycles represent the majority of FDA-approved small-molecule pharmaceuticals. Herein, we describe a synthetic method to produce saturated N-heterocyclic drug scaffolds with an internal alkyne for elaboration.
Christian Frabitore, Jérome Lépeule, Tom Livinghouse   +2 more
doaj   +1 more source

Catalytic Asymmetric C-N Bond Formation: Phosphine-Catalyzed Intra- and Intermolecular γ-Addition of Nitrogen Nucleophiles to Allenoates and Alkynoates [PDF]

, 2013
Pin the amine on the gamma: A new method has been developed for the γ-addition of nitrogen nucleophiles to γ-substituted alkynoates or allenoates through intra- and intermolecular processes that are catalyzed by spirophosphine 1 (see scheme).
Chung, Ying Kit, Fu, Gregory C., Lundgren, Rylan J., Ma, Cong, Marion, Nicolas, Wilsily, Ashraf   +5 more
core   +1 more source

Facile Synthesis of a Carbon Nano Dot‐Based Wearable Flexible Thermoelectric Device

Advanced Materials Technologies, EarlyView.
A wearable proto‐type device made with low‐cost, bio‐friendly, and environmentally safe materials that can be readily fabricated to generate energy from low waste temperatures is demonstrated. The Carbon Nano Dot composite thin films are supported by a flexible cellulose substrate that harnesses thermoelectric principles to generate power from body ...
Al Jumlat Ahmed, Joseph F. Olorunyomi, Shiqin Yan, Christopher D. Easton, Farnaz Zadehahmadi, Yannan Lu, Daniel Liang, Xavier Mulet, Cara M. Doherty   +8 more
wiley   +1 more source

Manipulation of Chemistry and Biology with Visible Light Using Tetra‐ortho‐Substituted Azobenzenes and Azonium Ions

Angewandte Chemie, EarlyView.
Tetra‐ortho‐Azobenzenes (TOABs) in broad daylight: in recent years, TOAB photoswitches became indispensable tools for all‐visible‐light manipulation of chemistry, biology and materials. This review explores their unique photochemical properties, design and synthetic approaches, offering support in choosing a TOAB for a given application.
Francesca Cardano, Rosa Márquez García, Wiktor Szymanski   +2 more
wiley   +2 more sources

A Straightforward Route to Enantiopure Pyrrolizidines and Indolizidines by Cycloaddition to Pyrroline N-Oxides Derived from the Chiral Pool

Molecules, 1998
Enantiomerically pure, five membered cyclic nitrones, easily obtained in large amounts from protected hydroxyacids and aminoacids such as D- and L-tartaric, L-malic, and L-aspartic acids, give cycloaddition reactions with a good diastereocontrol.
Alberto Brandi, Valentina Fedi, Franca M. Cordero, Stefano Cicchi, Andrea Goti   +4 more
doaj   +1 more source