Results 21 to 30 of about 4,019 (234)
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 111, Issue 2, Page 343-353, February 2023., 2023 Abstract Ligand targeted therapy (LTT) is a precision medicine strategy that can selectively target diseased cells while minimizing off‐target effects on healthy cells. Integrin‐targeted LTT has been developed recently for angiogenesis‐related diseases.
Neha Phani Bhushan +5 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2013 The four-component reaction of 2-aminobenzothiazole, aromatic aldehydes, acetylenedicarboxylate and piperidine or pyrrolidine in ethanol afforded the functionalized 2-pyrrolidinones containing both benzothiazolyl and piperidinyl (or pyrrolidinyl) units ...
Hong Gao, Jing Sun, Chao-Guo Yan
doaj +1 more source
Протон-ініційована циклізація N-aлкіламідів стирилоцтових кислот. Синтез 5-арилпіролідин-2-онів [PDF]
, 2018 Aim. To study the effect of the structural parameters of styrylacetic acid amides on the course of the reaction of the electrophilic intramolecular cyclization under the action of polyphosphoric acid and search the rational approaches to obtain N ...
Danyliuk, I. Yu. +4 more
core +4 more sources
Pyrrolidinodiones in Enol-Ugi, Enol-Passerini, and Anomalous Enol-Passerini Condensations
Proceedings, 2019 In continuation of our recent research on the development of novel multicomponent reactions with isocyanides, we have used, for the first time, enols as the acid components in Ugi- and Passerini-type reactions. Thus, electron-poor pyrrolidinodiones react
Ana G. Neo, Carlos F. Marcos
doaj +1 more source
Synthesis of Nitrogen Heterocycles by Hypervalent Iodine Mediated Cyclization [PDF]
, 2022 This thesis discusses the synthesis of 3-arylpyrrolidin-2-ones and the use of hypervalent iodine reagents in organic synthesis. With that being the case, the first chapter provides a brief introduction to nitrogen heterocycles and discusses methods ...
Ibrahim, Mohamed Raif
core
Synthesis of Spiroisoxazolines by 1,3-Dipolar Cycloaddition
Molecules, 1997 The cycloaddition of the chiral nitrile oxide 1 to 1-R-substituted 3,3-methylene-5,5-dimethyl-2-pyrrolidinones 2 (where R is H, n-butyl-, 1,1-dimethylethoxycarbonyl-, 1-methylethenyl- and acetyl-) proceeds regioselectively under the formation of ...
Peter Ertl +3 more
doaj +1 more source
Synthesis of a-chlorolactams by cyanoborohydride-mediated radical cyclization of trichloroacetamides [PDF]
, 2019 A cyanoborohydride-promoted radical cyclization methodology has been developed to access α-chlorolactams in a simple and efficient way, using NaBH3CN and trichloroacetamides easily available from allylic and homoallylic secondary amines. This methodology
Abe +52 more
core +1 more source
Novel Methodologies for the Photochemical and Photocatalytic Generation of Nitrogen-Containing Pharmacophores [PDF]
, 2018 Photochemical transformations give rise to radical intermediates that are enabling tools for constructing molecular scaffolds in alternative methods from traditional two-electron processes.
Thullen, Scott Macmillan
core +2 more sources
Green Processing and Synthesis, 2019 The energy efficiency of the microwave-assisted synthesis of pyrrolidinones was demonstrated using catalytic loading of 1,1’-butylene-bis(3-sulfo-3H-imidazol-1-ium) chloride as a sulfonic acid functionalized ionic liquid in ethylene glycol as green ...
Khaligh Nader Ghaffari +3 more
doaj +1 more source
A concise approach to functionalised, homochiral pyrrolidinones
Tetrahedron: Asymmetry, 1995 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bamford, M +3 more
openaire +3 more sources