Results 121 to 130 of about 4,162 (161)

Glutamine metabolism reprogramming promotes bladder cancer progression via PYCR1: a multi-omics and functional validation study. [PDF]

J Transl Med
Ding X, Zhang E, Huang Z, Li X, Wang Z, Wu Y, Liu C, Wu S.   +7 more
europepmc   +1 more source

Genome-Wide Identification and Comprehensive Analysis of the GS Gene Family in <i>Hordeum vulgare</i> Under Low Nitrogen Stress. [PDF]

Biology (Basel)
Pei Y, Wang J, Yao L, Si E, Yang K, Li B, Meng Y, Ma X, Zhang H, Shang X, Wang H.   +10 more
europepmc   +1 more source

Phytohormonal modulation alleviates arsenic toxicity in rice by enhancing antioxidant defenses, proline metabolism, and arsenic detoxification mechanisms. [PDF]

Sci Rep
Shaghaleh H, Alhaj Hamoud Y, Saleem MH, Elansary HO, Mahmoud EA, Sheteiwy MS.   +5 more
europepmc   +1 more source

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Characteristics of Δ1-pyrroline-5-carboxylate reductase from Drosophila melanogaster

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1979
1. Biochemical properties of delta 1-pyrroline-5-carboxylate reductase from d. melanogaster have been investigated. 2. The enzyme is stable below 4 degrees C. 3. the pH optimum of the enzyme is 5.7. It is rapidly inactivated below pH 5.4. 4. The Km values for NADPH and delta 1-pyrroline-5-carboxylate are 1.6 x 10-5 and 2.5 x 10-6 M, respectively.
William Bradshaw, W S Bradshaw
exaly   +3 more sources

Synthesis and Evaluation of Effective Inhibitors of Plant δ¹-Pyrroline-5-carboxylate Reductase

Journal of Agricultural and Food Chemistry, 2013
Analogues of previously studied phenyl-substituted aminomethylene-bisphosphonic acids were synthesized and evaluated as inhibitors of Arabidopsis thaliana δ(1)-pyrroline-5-carboxylate reductase. With the aim of improving their effectiveness, two main modifications were introduced into the inhibitory scaffold: the aminomethylenebisphosphonic moiety was ...
FORLANI, Giuseppe, Berlicki Ł., Duò M., Dziędzioła G., GIBERTI, Samuele, BERTAZZINI, Michele, Kafarski P.   +6 more
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Cutis Laxa Type II with Mutation in the Pyrroline‐5‐Carboxylate Reductase 1 Gene

Pediatric Dermatology, 2013
AbstractA 14‐year‐old Iranian boy with congenital cutis laxa and several other typical autosomal recessive type II features was examined. Mutation analysis of the pyrroline‐5‐carboxylate reductase 1 gene revealed a single‐base deletion (c.345delC) in exon 4 leading to frame shift and premature termination of translation.
Nayereh, Nouri, Omid, Aryani, Narges, Nouri, Behnam, Kamalidehghan, Massoud, Houshmand   +4 more
openaire   +2 more sources

Pyrroline-5-Carboxylate Reductase 1 Accelerates the Migration and Invasion of Nonsmall Cell Lung Cancer In Vitro

Cancer Biotherapy and Radiopharmaceuticals, 2019
Background: Pyrroline-5-carboxylate reductase 1 (PYCR1) is involved in tumor progression, for instance, breast cancer and prostate cancer. However, its role in tumor metastasis, especially in nonsmall cell lung cancer (NSCLC), is still elusive. Materials and Methods: The messenger RNA (mRNA) expression of PYCR1 between NSCLC and normal lung specimens ...
Senhua, Sang, Cuicui, Zhang, Jianwei, Shan   +2 more
openaire   +2 more sources

Possible involvement of a L-Δ1-pyrroline-5-carboxylate (P5C) reductase in the synthesis of proline in Desulfovibrio desulfuricans Norway

Biochemical and Biophysical Research Communications, 1991
A L-delta 1-pyrroline-5-carboxylate reductase activity has been detected in crude extracts of Desulfovibrio desulfuricans Norway. This P5C reductase activity is also found when a 2.5 kb D. desulfuricans DNA fragment is introduced into an Escherichia coli proC mutant.
Marc Chippaux
exaly   +4 more sources

Molecular characterization of theproline-1 (pro-1) locus ofNeurospora crassa, which encodes Δ1-pyrroline-5-carboxylate reductase

Molecular and General Genetics MGG, 1995
delta 1-pyrroline-5-carboxylate reductase (P5CR; [L-proline: NAD(P+) 5-oxidoreductase]; EC 1.5.1.2) catalyzes the final step in proline biosynthesis. We have shown that the proline-1 (pro-1) locus of Neurospora crassa encodes P5CR. The pro-1 gene was localized to a 3.2 kb region by complementation of (restoration of proline-independent growth to) a ...
C R, Davis, M A, McPeek, C R, McClung
openaire   +2 more sources