Results 141 to 150 of about 4,162 (161)
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Disease of the ornithine-proline pathway: delta 1-pyrroline-5-carboxylate reductase deficiency in the retina of retinal degeneration mice.

Metabolic, pediatric, and systemic ophthalmology, 1983
In bovine ocular tissues, cornea and retina-including choroid provide the intracellular proline synthetic pathway from ornithine, but not from glutamate. In C3H retinal degeneration mice, P5C reductase activity in the retina and choroid was decreased to about one-third that of CRJ control mice in the specific activity after the tenth day.
openaire   +1 more source

Serendipitous Discovery of an Allosteric Inhibitor Binding Groove in the Proline Biosynthetic Enzyme Pyrroline-5-Carboxylate Reductase 1 (PYCR1).

The Biochemical journal
Δ1-pyrroline-5-carboxylate (P5C) reductase 1 (PYCR1) catalyzes the NAD(P)H-dependent conversion of L-P5C to L-proline and is one of the most consistently upregulated metabolic enzymes in cancer cells. High PYCR1 expression is associated with adverse clinical outcomes, and its knockdown inhibits tumor proliferation and metastasis, motivating inhibitor ...
Kaylen R, Meeks   +6 more
openaire   +1 more source

Pyrroline-5-carboxylate reductase from Cucurbita cotyledons

Phytochemistry, 1973
Walter E Splittstoesser
exaly  

Structure of Thermococcus litoralis Δ1-pyrroline-2-carboxylate reductase in complex with NADH and L-proline

Acta Crystallographica Section D: Structural Biology, 2020
Davide Maria Ferraris   +2 more
exaly  

Delta 1-pyrroline-5-carboxylate reductase homolog

2000
HILLMAN JENNIFER L   +2 more
openaire   +2 more sources

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