Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism [PDF]
Diabetes & Metabolism Journal, 2018 Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex
Sungmi Park +6 more
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Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion [PDF]
Nature Communications, 2021 The pyruvate dehydrogenase complex (PDHc) is a large multienzyme complex that converts pyruvate into acetyl-coenzyme A and in E. coli the core of the PDHc is formed by 24 copies of dihydrolipoyl transacetylase.
Jana Škerlová +4 more
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The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy [PDF]
Frontiers in Nutrition, 2021 Anaerobic glycolysis is the process by which glucose is broken down into pyruvate and lactate and is the primary metabolic pathway in sepsis. The pyruvate dehydrogenase complex (PDHC) is a multienzyme complex that serves as a critical hub in energy ...
Zhenhua Zeng +6 more
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Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex [PDF]
Nature Communications, 2020 The pyruvate dehydrogenase complex (PDC) is a multienzyme complex connecting glycolysis to mitochondrial oxidation of pyruvate. Cryo-EM analysis of PDC from Neurospora crassa reveals localization of fungi-specific protein X (PX) and confirms that it ...
B. O. Forsberg +4 more
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Cell Reports, 2021 Summary: The pyruvate dehydrogenase complex (PDHc) is a giant enzymatic assembly involved in pyruvate oxidation. PDHc components have been characterized in isolation, but the complex’s quaternary structure has remained elusive due to sheer size ...
Fotis L. Kyrilis +7 more
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TGF-β1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts. [PDF]
Sci Rep, 2020 TGF-β1 reprograms metabolism in renal fibroblasts, inducing a switch from oxidative phosphorylation to aerobic glycolysis. However, molecular events underpinning this are unknown.
Smith ER, Hewitson TD.
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Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury
Brain Circulation, 2016 Pyruvate dehydrogenase (PDH) complex is a mitochondrial matrix enzyme that serves a critical role in the conversion of anaerobic to aerobic cerebral energy.
Alexa Thibodeau +3 more
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The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4 [PDF]
Diabetes & Metabolism Journal, 2023 Sarcopenia, defined as a progressive loss of muscle mass and function, is typified by mitochondrial dysfunction and loss of mitochondrial resilience. Sarcopenia is associated not only with aging, but also with various metabolic diseases characterized by ...
Min-Ji Kim +4 more
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Glutathionylation of pyruvate dehydrogenase complex E2 and inflammatory cytokine production during acute inflammation are magnified by mitochondrial oxidative stress [PDF]
Redox Biology, 2023 Lipopolysaccharide (LPS) is a known inducer of inflammatory signaling which triggers generation of reactive oxygen species (ROS) and cell death in responsive cells like THP-1 promonocytes and freshly isolated human monocytes.
David L. Long +2 more
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Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer [PDF]
Frontiers in Oncology, 2022 BackgroundPyruvate dehydrogenase (PDH) complex converts pyruvate into acetyl-CoA by pyruvate decarboxylation, which drives energy metabolism during cell growth, including prostate cancer (PCa) cell growth.
Caroline E. Nunes-Xavier +11 more
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