Results 151 to 160 of about 158,743 (322)

Perioperative considerations of pyruvate dehydrogenase complex deficiency: a case report of two consecutive anesthesia. [PDF]

Anesth Pain Med (Seoul), 2023
Lim WY, Lee HJ, Park EJ, Jeon S, Do W, Kim HJ, Lee D, Hong JM.   +7 more
europepmc   +1 more source

Adaptations in Protein Expression and Regulated Activity of Pyruvate Dehydrogenase Multienzyme Complex in Human Systolic Heart Failure [PDF]

, 2019
Freya L. Sheeran, Julie Angerosa, Norman Y. Liaw, Michael M.H. Cheung, Salvatore Pepe   +4 more
openalex   +1 more source

An Enzyme‐Like Catalyzed Nanosheets for Redox Stress Oscillation Therapy Against Bacterial Infections

Advanced Science, EarlyView.
Bacterial biofilms form a physicochemical barrier. Their dense network structure and redox homeostasis confer high resistance to antimicrobial treatments and immune‐mediated killing and clearance. In this study, SnSe nanosheets with enzyme‐like properties and piezoelectric catalysis can oscillate to regulate bacterial redox homeostasis and improve the ...
Min Ge, Zhao Guo, Zhiming Zhang, Lanlu Lu, Zesong Ruan, Tingwang Shi, Yunfeng Chen, Ju Huang, Chaoliang Tan, Han Lin   +9 more
wiley   +1 more source

PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α

Genes and Diseases
Pyruvate dehydrogenase kinase 1 (PDK1) phosphorylates the pyruvate dehydrogenase complex, which inhibits its activity. Inhibiting pyruvate dehydrogenase complex inhibits the tricarboxylic acid cycle and the reprogramming of tumor cell metabolism to ...
Yu Wei, Dian Zhang, He Shi, Husun Qian, Hongling Chen, Qian Zeng, Fangfang Jin, Yan Ye, Zuli Ou, Minkang Guo, Bianqin Guo, Tingmei Chen   +11 more
doaj   +1 more source

Comparative development of the pyruvate dehydrogenase complex and citrate synthase in rat brain mitochondria [PDF]

, 1986
Gavin Malloch, L A Munday, Merle S. Olson, J. B. Clark   +3 more
openalex   +1 more source

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

Structural Insight into Interactions between Dihydrolipoamide Dehydrogenase (E3) and E3 Binding Protein of Human Pyruvate Dehydrogenase Complex [PDF]

, 2006
Chad A. Brautigam, Richard Wynn, Jacinta L. Chuang, Mischa Machius, Diana R. Tomchick, David Chuang   +5 more
openalex   +1 more source

Biogenesis of Organelles and Membrane Proteins. [PDF]

, 1988
Harmey, Matthew A., Neupert, Walter, Nicholson, Donald W., Stuart, Rosemary A.   +3 more
core   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Pyruvate Dehydrogenase Complex and Glucose Oxidation as a Therapeutic Target in Diabetic Heart Disease. [PDF]

J Lipid Atheroscler, 2023
Tabatabaei Dakhili SA, Greenwell AA, Ussher JR.   +2 more
europepmc   +1 more source