Results 31 to 40 of about 145,751 (270)
The relationships between transketolase, yeast pyruvate decarboxylase and pyruvate dehydrogenase of the pyruvate dehydrogenase complex [PDF]
FEBS Letters, 1993 The amino acid sequences of four thiamine pyrophosphate‐requiring enzymes were aligned with the published amino acid sequence of the transketolase of Hansenula polymorpha. Sequences of the combined α and β subunits of the E1 enzyme of the pyruvate dehydrogenase complexes of Homo sapiens and Bacillus stearothermophilus aligned well with the ...
Robinson, Brian H., Chun, Kathy
openaire +2 more sources
Ketogenic diet in pyruvate dehydrogenase complex deficiency: short- and long-term outcomes
Journal of Inherited Metabolic Disease, 2017 ObjectivesOur aime was to study the short- and long-term effects of ketogenic diet on the disease course and disease-related outcomes in patients with pyruvate dehydrogenase complex deficiency, the metabolic factors implicated in treatment outcomes, and ...
K. Sofou +5 more
semanticscholar +1 more source
Nature Genetics, 2017 The mechanisms by which mitochondrial metabolism supports cancer anabolism remain unclear. Here, we found that genetic and pharmacological inactivation of pyruvate dehydrogenase A1 (PDHA1), a subunit of the pyruvate dehydrogenase complex (PDC), inhibits ...
Jingjing Chen +29 more
semanticscholar +1 more source
JIMD Reports, 2019 Congenital lactic acidosis due to pyruvate dehydrogenase phosphatase (PDP) deficiency is very rare. PDP regulates pyruvate dehydrogenase complex (PDC) and defective PDP leads to PDC deficiency.
Jirair K. Bedoyan +12 more
doaj +1 more source
Metabolic Engineering, 2019 Genetic manipulation in cyanobacteria enables the direct production of valuable chemicals from carbon dioxide. However, there are still very few reports of the production of highly effective photosynthetic chemicals. Several synthetic metabolic pathways (
Yasutaka Hirokawa +4 more
semanticscholar +1 more source
Scientific Reports, 2017 Resveratrol (RES), a polyphenol found in natural foods, displays anti-oxidant, anti-inflammatory and anti-proliferative properties potentially beneficial in cancers, in particular in the prevention of tumor growth.
E. Saunier +10 more
semanticscholar +1 more source
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2023 Dichloroacetate (DCA) is a naturally occurring xenobiotic that has been used as an investigational drug for over 50 years. Originally found to lower blood glucose levels and alter fat metabolism in diabetic rats, this small molecule was found to serve ...
Nick Schoenmann +3 more
semanticscholar +1 more source
Folia Morphologica, 2020 The main source of energy for brain and other organs is glucose. To obtain energy for all tissue, glucose has to come through glycolysis; then as pyruvate it is converted to acetyl-CoA by pyruvate dehydrogenase complex (PDC) and finally enters citric ...
A. Ebertowska +4 more
doaj +1 more source
The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells
Cells, 2021 Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed by numerous cell-intrinsic and extrinsic factors.
Edward V. Prochownik, Huabo Wang
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Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.
JCI Insight, 2018 Limited understanding of the mechanisms responsible for life-threatening organ and immune failure hampers scientists' ability to design sepsis treatments.
C. McCall +10 more
semanticscholar +1 more source