Results 41 to 50 of about 145,751 (270)
Scientific Reports, 2017 Without oxygen, most vertebrates die within minutes as they cannot meet cellular energy demands with anaerobic metabolism. However, fish of the genus Carassius (crucian carp and goldfish) have evolved a specialized metabolic system that allows them to ...
Cathrine E. Fagernes +5 more
doaj +1 more source
Journal of Biological Chemistry, 2018 The pyruvate dehydrogenase complex (PDC) is a multienzyme assembly that converts pyruvate to acetyl-CoA. As pyruvate and acetyl-CoA play central roles in cellular metabolism, understanding PDC regulation is pivotal to understanding the larger metabolic ...
Alla V Klyuyeva +3 more
semanticscholar +1 more source
Neurobiology of Disease, 2016 Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral neuropathy. An X-linked form of CMT (CMTX6) is caused by a missense mutation (R158H) in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.
Gonzalo Perez-Siles +9 more
doaj +1 more source
Ketogenic diet in action: Metabolic profiling of pyruvate dehydrogenase deficiency
Molecular Genetics and Metabolism Reports, 2023 The pyruvate dehydrogenase complex serves as the main connection between cytosolic glycolysis and the tricarboxylic acid cycle within mitochondria. An infant with pyruvate dehydrogenase complex deficiency was treated with vitamin B1 supplementation and a
Eri Ogawa +6 more
doaj +1 more source
Inhibition of pyruvate dehydrogenase complex by moniliformin [PDF]
Biochemical Journal, 1986 The mechanism for the inhibition of pyruvate dehydrogenase complex from bovine heart by moniliformin was investigated. Thiamin pyrophosphate proved to be necessary for the inhibitory action of moniliformin. The inhibition reaction was shown to be time-dependent and to follow first-order and saturation kinetics.
P S, Gathercole +2 more
openaire +2 more sources
Regulation of Brain Pyruvate Dehydrogenase Multienzyme Complex [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1978 SUMMARY:A number of excellent and comprehensive reviews on various aspects of pyruvate dehydrogenase multienzyme complex have been written recently. The purpose of the present review is to summarize briefly the reaction mechanism and the regulation of this enzyme. Emphasis is put on the most recent literature not covered by previous reviews. Particular
T T, Ngo, A, Barbeau
openaire +2 more sources
Oxidative Medicine and Cellular Longevity, 2019 Pyruvate dehydrogenase (PDH) complex, a multienzyme complex at the nexus of glycolytic and Krebs cycles, provides acetyl-CoA to the Krebs cycle and NADH to complex I thus supporting a critical role in mitochondrial energy production and cellular survival.
F. Sheeran +4 more
semanticscholar +1 more source
Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
Bioscience Reports, 2021 Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it further links glycolysis with the tricarboxylic acid cycle and ATP generation. This
Xiuxiu Wang +3 more
semanticscholar +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source