Results 61 to 70 of about 96,844 (281)

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer [PDF]

, 2018
The mechanisms by which mitochondrial metabolism supports cancer anabolism remain unclear. Here, we found that genetic and pharmacological inactivation of pyruvate dehydrogenase A1 (PDHA1), a subunit of the pyruvate dehydrogenase complex (PDC), inhibits ...
Guccini I., Rasola, A., Chiarugi, P., Morandi, A, Rinaldi A. a, Pinton, S, Montopoli M., Crotti, S, Rinaldi, A, Crotti S., Cavalli A., Monica Montopoli, Jacopo Sgrignani, Civenni, G, Guccini, I., Morandi A., Emiliano Pasquini, Garcia-Escudero, R., Asara, J.M., Crotti, S., Pinton S., Brina, D., Agostini, M., Morandi, Andrea, Cavalli, A, Morandi, A., Manuela Sarti, Carlo V. Catapano, Montopoli, M., Bono, J., Ajinkya Revandkar, Paola Chiarugi, Catapano, C.V., Nicolas Delaleu, D'Antuono, R., Civenni G., Agostini, M, Asara J. M., Masgras, I, Bono, JD, Gianluca Civenni, Andrea Rasola, Chiarugi, Paola, Chiarugi P., Daniela Brina, Sgrignani, J., Di Mitri, D, Brina D., Masgras I., Ionica Masgras, Johann de Bono, Abdullah Alajati, Guccini, I, Delaleu, N., Chen, J., Sarti, M., Sandra Pinton, D'Antuono R., Pasquini, E, Carracedo, A., Sgrignani, Jacopo, Garcia-Escudero, Alimonti A., Sarti M., Losa M., Arkaitz Carracedo, Sgrignani J., Ramon Garcia-Escudero, Bertoni F. a, D'Antuono, R, Brina, D, Rasola, A, Alajati, A., Garcia-Escudero, R, Jingjing Chen, Revandkar, A., R. klm, Andrea Cavalli, Rocco D’Antuono, Andrea Rinaldi, Alimonti, A, Diletta Di Mitri, Pasquini, E., Andrea Morandi, Rasola A., Marco Agostini, Carracedo, A, Di Mitri, D., Marco Losa, Asara, JM, Catapano, CV, Bono J. D. o, Chiarugi, P, Montopoli, M, Pinton, S., Losa, M, Alajati A., Sara Crotti, Chen, J, Rinaldi, A., Civenni, G., Catapano C. V., Bertoni, F., Revandkar, A, Sarti, M, Delaleu, N, Andrea Alimonti, John M. Asara, Ilaria Guccini, Mitri D. D., Carracedo A., Sgrignani, J, Agostini M., Chen J., Alajati, A, Losa, M., Alimonti, A., Cavalli, A., Francesco Bertoni, Pasquini E., Bertoni, F, Revandkar A., Delaleu N. n, Masgras, I.   +123 more
core   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

Cell Reports, 2020
Summary: The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to ...
Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P. Norenberg, W. Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers   +40 more
doaj   +1 more source

Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway

Molecular Medicine, 2022
The mechanisms of chronic intermittent hypoxia (CIH)-induced cognitive deficits remain unclear. Here, our study found that about 3 months CIH treatment induced lipid droplets (LDs) accumulation in hippocampal nerve and glia cells of C57BL/6 mice, and ...
Dongze Li, Na Xu, Yanyan Hou, Wenjing Ren, Na Zhang, Xi Wang, Yeying Sun, Wenxue Lu, Guiwu Qu, Yan Yu, Changjun Lv, Fang Han   +11 more
doaj   +1 more source

Prenatal presentation of pyruvate dehydrogenase complex deficiency [PDF]

Pediatric Radiology, 2016
We present the case of a female infant referred for prenatal MR evaluation of ventriculomegaly, which had been attributed by the referring obstetrician to aqueductal stenosis. Fetal MR confirmed ventriculomegaly but also demonstrated cerebral volume loss and white matter abnormalities. After birth, the infant developed persistent lactic acidosis.
Niranjana, Natarajan, Hannah M, Tully, Teresa, Chapman   +2 more
openaire   +2 more sources

3D‐Printed Piezoionic/Bioelectronic Hydrogel for Electro‐Metabolic Regulation of Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
A 3D‐printed piezoionic GPMx hydrogel enables stable electromechanical signal generation under mechanical loading, exhibiting long‐term durability and low fatigue. As a bioactive patch, it restores endogenous bioelectricity to stimulate osteogenesis via Ca2+ influx and mitochondrial activation, while simultaneously enabling label‐free alkaline ...
Sayan Deb Dutta, Myoung Joon Jeon, Youjin Seol, Ki‐Taek Lim   +3 more
wiley   +1 more source

Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta-catenin pathway

Clinical and Translational Medicine, 2017
Cancer cells are the site of numerous metabolic and thermodynamic abnormalities. We focus this review on the interactions between the canonical WNT/beta-catenin pathway and peroxisome proliferator-activated receptor gamma (PPAR gamma) in cancers and ...
Yves Lecarpentier, Victor Claes, Alexandre Vallée, Jean-Louis Hébert   +3 more
doaj   +1 more source

Immunological studies with pyruvate dehydrogenase complex

, 1972
Immunological studies with pyruvate dehydrogenase ...
Wagner, R. P., R. P. Wagner, Harding, R. W., R. W. Harding   +3 more
core   +1 more source

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source

Pyruvate Dehydrogenase Complex

, 2016
Educação Superior::Ciências Biológicas::BioquímicaPresents the Pyruvate Dehydrogenase Complex (PDC), its importance, its function, where it is and how the reaction occurs in the process of glicolysis.
LearnersTV
core   +1 more source