Results 111 to 120 of about 16,904 (180)

Mitochondrial Dysfunction and Reduced TCA Cycle Metabolite Levels in Inflammatory Bowel Disease Patients. [PDF]

J Inflamm Res
Dudzińska E, Madro A, Sauer AK, Grabrucker AM, Strachecka A.   +4 more
europepmc   +1 more source

Leveraging core enzyme structures for microbiota targeted functional regulation: Urease as an example

iMeta, Volume 4, Issue 3, June 2025.
We present an innovative methodology that integrates core enzyme identification, protein structural characterization, regulator virtual screening, and functional validation to achieve precise microbiome functional regulation. As a proof of concept, we focused on the regulation of urea decomposition by the rumen microbiota in ruminants. This methodology
Shengguo Zhao, Huiyue Zhong, Yue He, Xiaojiao Li, Li Zhu, Zhanbo Xiong, Xiaoyin Zhang, Nan Zheng, Diego P. Morgavi, Jiaqi Wang   +9 more
wiley   +1 more source

Hepatic Form of Dihydrolipoamide Dehydrogenase Deficiency (DLDD): Phenotypic Spectrum, Laboratory Findings, and Therapeutic Approaches in 52 Patients. [PDF]

J Inherit Metab Dis
Hammann N, Staufner C, Schlieben LD, Dezsőfi-Gottl A, Feichtinger RG, Häberle J, Junge N, Konstantopoulou V, Kopajtich R, McLin V, Rymen D, Slavetinsky C, Sturm E, Mayr JA, Wagner M, Kölker S, Prokisch H, Hoffmann GF, Lenz D.   +18 more
europepmc   +1 more source

Single‐microbe RNA sequencing uncovers unexplored specialized metabolic functions of keystone species in the human gut

iMeta, Volume 4, Issue 3, June 2025.
The human body is inhabited by trillions of microorganisms that play a crucial role in health and diseases. Although our understanding of the species and functional composition of the human gut microbiome is rapidly expanding, species–function heterogeneity and dynamic activities in human microecosystem niches remain unclear.
Yifei Shen, Wenxin Qu, Mengdi Song, Tianyu Zhang, Chang Liu, Xiaofeng Shi, Xinxin Xu, Jingjing Jiang, Liguo Ding, Fangyu Mo, Zheying Mao, Mingzhu Huang, Ziye Xu, Jiaye Chen, Enhui Shen, Jian Ruan, Jiong Liu, Michael P. Timko, Yu Chen, Longjiang Fan, Shufa Zheng, Yongcheng Wang   +21 more
wiley   +1 more source

Macrophage and Preeclampsia: Macrophage Polarization Imbalance at the Maternal‐Fetal Interface

Journal of Clinical Laboratory Analysis, Volume 39, Issue 11, June 2025.
The development and progression of preeclampsia (PE) are associated with immune‐inflammatory responses induced by placental dysfunction. The polarization imbalance of decidual macrophages, particularly the increase in M1 polarization, exacerbates placental inflammation.
Yao Wei, Yang Su, Cheng Liu, Xiaolong Ma, Zihui Ling, Yilin Wang, Rui Qiao   +6 more
wiley   +1 more source

Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies

MedComm, Volume 6, Issue 6, June 2025.
Lactylation, a novel post‐translational modification derived from lactate metabolism, plays a critical role in cellular homeostasis and disease pathogenesis. Under physiological conditions, lactylation regulates gene expression, immune responses, and metabolic adaptation. However, dysregulated lactylation is implicated in various pathological processes,
Xi Chen, Yixiao Yuan, Fan Zhou, Lihua Li, Jun Pu, Yong Zeng, Xiulin Jiang   +6 more
wiley   +1 more source

Mitochondrial Transplantation: A Novel Therapeutic Approach for Treating Diseases

MedComm, Volume 6, Issue 6, June 2025.
This article describes the roles of mitochondria in health and disease and reviews the effects of mitochondrial transplantation in disease, including restoring ATP production, attenuating oxidative stress, modulating inflammatory responses, reducing apoptosis, promoting cell repair, and exhibiting antitumor properties.
Xinglu Miao, Pei Jiang, Zhaoping Wang, Weihua Kong, Lei Feng   +4 more
wiley   +1 more source

Therapeutic Targeting of Decr1 Ameliorates Cardiomyopathy by Suppressing Mitochondrial Fatty Acid Oxidation in Diabetic Mice. [PDF]

J Cachexia Sarcopenia Muscle
Lu QB, Sun HT, Zhou K, Su JB, Meng XY, Chen G, Zhang AY, Xu AJ, Zhao CY, Zhang Y, Wang Y, Qiu HB, Lv ZL, Bao ZY, Zhu J, Xiao F, Zhu XX, Sun HJ.   +17 more
europepmc   +1 more source

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen, Huanle Qi, Yapeng Xue, Yaqi Zhang, Zhuo Zhang, Shun Xu, Shixin Liao, Xiaoyu Zeng, Jiayi Wu, Xinrui Lv, Qiankun He, Pingping Zhu   +11 more
wiley   +1 more source

A Systematic Review of Thiamine Supplementation in Improving Diabetes and Its Related Cardiovascular Dysfunction. [PDF]

Int J Mol Sci
Serra M, Mollace R, Ritorto G, Ussia S, Altomare C, Tavernese A, Preianò M, Palma E, Muscoli C, Mollace V, Macrì R.   +10 more
europepmc   +1 more source