Recent Advances on the Role of B Vitamins in Cancer Prevention and Progression. [PDF]
Frost Z+4 more
europepmc +1 more source
Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease
Improved reactive oxygen species scavenging capacities of functionalized micro/nanorobots (MNRs) are useful for the treatment of inflammatory bowel disease (IBD). MNRs can break the harmful bacteria in IBD, thereby eliminating inflammation and restoring the intestinal barrier function.
Ying Feng+5 more
wiley +1 more source
Pyruvate dehydrogenase deficiency in a female due to a 4 base pair deletion in exon 10 of the E1α gene [PDF]
Benelli, Chantal+9 more
core
This study uses comprehensive quantitative proteomics of 151 melanoma‐related samples to demonstrate that the upregulation of mitochondrial translation and oxidative phosphorylation is intricately linked to tumor aggressiveness, treatment resistance, and poor clinical outcomes.
Yonghyo Kim+29 more
wiley +1 more source
Oxidant-Based Cytotoxic Agents During Aging: From Disturbed Energy Metabolism to Chronic Inflammation and Disease Progression. [PDF]
Arnhold J.
europepmc +1 more source
Decoding the pancreatic cancer microenvironment: The multifaceted regulation of microRNAs
miRNAs play multiple roles in the tumour microenvironment of pancreatic cancer, including angiogenesis, interactions with cancer‐associated fibroblasts, the immune microenvironment, exosome communication, the neural microenvironment and metabolic reprogramming.
Jie Ji+9 more
wiley +1 more source
The neglected PCK1/glucagon (inter)action in nutrient homeostasis beyond gluconeogenesis: Disease pathogenesis and treatment. [PDF]
Bertinat R+5 more
europepmc +1 more source
Itaconate suppresses neonatal intestinal inflammation via metabolic reprogramming of M1 macrophage
Itaconate alleviates NEC by reprogramming M1 macrophage metabolism. ACOD1 deficiency exacerbates NEC severity. 4OI maintains intestinal barrier integrity. 4OI rescues NEC by regulating macrophage mitochondrial activity. Abstract Background Necrotizing enterocolitis (NEC) is a rapidly progressive and severe gastrointestinal disorder in neonates that is ...
Shuchen Huangfu+14 more
wiley +1 more source
Metabolic Reprogramming in Stromal and Immune Cells in Rheumatoid Arthritis and Osteoarthritis: Therapeutic Possibilities. [PDF]
Henry ÓC, O'Neill LAJ.
europepmc +1 more source
Alpha‐lipoic acid (ALA) plays a significant role in alleviating isoflurane‐induced cognitive dysfunction in juvenile mice by activating PGC‐1α, which improves mitochondrial function and energy metabolism in astrocytes. As a potent antioxidant, ALA is commonly found in foods like spinach, broccoli, and yeast, and its supplementation may offer ...
Xingkai Zhao+4 more
wiley +1 more source