Results 171 to 180 of about 42,696 (258)

Decoding the pancreatic cancer microenvironment: The multifaceted regulation of microRNAs

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
miRNAs play multiple roles in the tumour microenvironment of pancreatic cancer, including angiogenesis, interactions with cancer‐associated fibroblasts, the immune microenvironment, exosome communication, the neural microenvironment and metabolic reprogramming.
Jie Ji, Dandan Jin, Junpeng Zhao, Xudong Xie, Yujie Jiao, Xuyang He, Yuxuan Huang, Lirong Zhou, Mingbing Xiao, Xiaolei Cao   +9 more
wiley   +1 more source

An atypical presentation in a child with propionic acidemia? Better think twice! [PDF]

JIMD Rep
Burkhardt T, Kastor KL, Christ S, Opladen T, Staufner C, Beck-Wödl S, Haack T, Hempel M, Seitz A, Kölker S.   +9 more
europepmc   +1 more source

Morin as a Modulator of Hepatic Glucose Fluxes: A Balance Between Antihyperglycemic Potential and Mitochondrial Toxicity

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 7, July 2025.
Morin modulates hepatic glucose metabolism by inhibiting gluconeogenesis and enhancing glycogenolysis in perfused rat livers. These effects, partly attributed to mitochondrial dysfunction and impaired oxidative phosphorylation, are accompanied by decreased ATP levels and enzyme inhibition, raising concerns about bioenergetic imbalance and potential ...
Letícia Fernanda Nanami, Eduardo Makiyama Klosowski, Márcio Shigueaki Mito, Giovana Natiele Machado Esquissato, Gabriel Arcanjo Viana, Ana Clara Oliveira Abido, Mariane Carneiro da Silva, Ana Paula da Silva Mendonça, Gabriele Sauthier Romano de Melo, Paulo Sérgio Alves Bueno, Francielle Pelegrin Garcia, Danielle Lazarin Bidoia, Tânia Ueda Nakamura, Celso Vataru Nakamura, Emy Luiza Ishii‐Iwamoto, Ana Paula Ferro, Wanderley Dantas dos Santos, Osvaldo Ferrarese‐Filho, Rogério Marchiosi, Rodrigo Polimeni Constantin   +19 more
wiley   +1 more source

Recent Advances on the Role of B Vitamins in Cancer Prevention and Progression. [PDF]

Int J Mol Sci
Frost Z, Bakhit S, Amaefuna CN, Powers RV, Ramana KV.   +4 more
europepmc   +1 more source

A Minor Haplotype Variant Determines the Pathogenicity of the p.Ile279Thr Substitution in the Primary Hyperoxaluria Type 1 Gene, AGXT

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT Human alanine:glyoxylate aminotransferase (AGT) is a liver peroxisomal enzyme that metabolizes glyoxylate, the oxalate precursor, to glycine. AGT deficiency, due to recessive pathogenic changes in the AGXT gene, results in calcium oxalate accumulation and kidney stones, a condition known as primary hyperoxaluria type 1 (PH1).
Luana Ruta, Andrea G. Cogal, Gioena Pampalone, David J. Sas, John C. Lieske, Gill Rumsby, Barbara Cellini, Peter C. Harris   +7 more
wiley   +1 more source

Say hello to my little friend… micronutraceuticals in neuroenergetics, neuronal health, and neurodegenerative diseases. [PDF]

Front Neurosci
Mason S.
europepmc   +1 more source

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira S. Al‐Shabeeb Akil, Muzafar A. Macha, Ajaz A. Bhat   +10 more
wiley   +1 more source

Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

MedComm, Volume 6, Issue 7, July 2025.
TET family proteins play a critical role in DNA demethylation, and their mutations and dysregulation contribute to the onset of multiple diseases. With a deeper understanding of the molecular mechanisms of TET involvement in disease, drug therapy targeting TET proteins shows great potential, which provides insights into new therapeutic strategies ...
Junzhi Liang, Xinni Na, Lingbo Meng, Lixia He, Ting Shu, Yuanyuan Fang, Bowen Zhang, Zhongyu Zhao, Cuishan Guo, Tingting Li, Zhijing Na, Da Li, Xue Xiao   +12 more
wiley   +1 more source

Oxidant-Based Cytotoxic Agents During Aging: From Disturbed Energy Metabolism to Chronic Inflammation and Disease Progression. [PDF]

Biomolecules
Arnhold J.
europepmc   +1 more source

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

MedComm, Volume 6, Issue 7, July 2025.
Oxidative stress causes cellular damage across multiple systems, contributing to neurodegeneration (Alzheimer's, Parkinson's, Huntington's), cancer progression and resistance, cardiovascular diseases (atherosclerosis, heart failure), liver and kidney injury, metabolic disorders (diabetes, obesity), autoimmune diseases, musculoskeletal decline, retinal ...
Sixuan Liu, Jiachen Liu, Yinhuai Wang, Fei Deng, Zebin Deng   +4 more
wiley   +1 more source