Results 161 to 170 of about 181,145 (327)

Bottom‐up Strategies for Generating Polymer Protocells That Mimic Cellular Communication

Chemistry – A European Journal, EarlyView.
This review focuses on polymeric protocells produced using a bottom‐up approach. Polymer‐based assemblies guarantee stability and designability by adjusting the properties of the amphiphilic copolymers used. The review covers protocell architectures, production, and their intra‐ and intercellular communication mechanisms.
Gloria Saorin, Xinan Huang, Voichita Mihali, Cornelia G. Palivan   +3 more
wiley   +1 more source

Evaluation of on growth and metabolism of NB-1691, an MYCN-amplified neuroblastoma cell line

Tumor Biology, 2018
Outcomes of children with high grade neuroblastoma remain poor despite multi-agent chemotherapy regimens. Rhodiola crenulata extracts display anti-neoplastic properties against several cancers including breast cancer, melanoma, and glioblastoma.
Kaitlyn E Wong, Maria C Mora, Nazneen Sultana, Kevin P Moriarty, Richard B Arenas, Nagendra Yadava, Sallie S Schneider, Michael V Tirabassi   +7 more
doaj   +1 more source

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase

, 2005
Integrating biological information from different sources to understand cellular processes is an important problem in systems biology. We use data from mRNA expression arrays and chemical kinetics to formulate a metabolic model relevant to K562 ...
Akesson, Baker, Barkai, Borgmann, Dang, Fan, Ferea, Goodacre, Griffiths, Gross, Joel R. Sevinsky, Joshua Downer, Jungmann, Kal, Karan, Katheryn A. Resing, Kim, Kitano, Kondoh, Koslowski, Koukourakis, Lambeth, Lewis, Lewis, Li, M.D. Betterton, Maekawa, Mazurek, Mulquiney, Munoz-Pinedo, Natalie G. Ahn, Newell, Osthus, Papas, Press, Riera, Segal, Sevinsky, Shim, Stambaugh, Stephanopoulos, Stubbs, Tilton, Unwin, Voet, von Dassow, Walenta, Warburg   +47 more
core   +1 more source

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis

EMBO Molecular Medicine, 2015
Amyotrophic lateral sclerosis (ALS) is the most common fatal motor neuron disease in adults. Numerous studies indicate that ALS is a systemic disease that affects whole body physiology and metabolic homeostasis.
Lavinia Palamiuc, Anna Schlagowski, Shyuan T Ngo, Aurelia Vernay, Sylvie Dirrig‐Grosch, Alexandre Henriques, Anne‐Laurence Boutillier, Joffrey Zoll, Andoni Echaniz‐Laguna, Jean‐Philippe Loeffler, Frédérique René   +10 more
doaj   +1 more source

Structure of Pyruvate Dehydrogenase Kinase [PDF]

Journal of Biological Chemistry, 2001
C. Nicklaus Steussy, Kirill M. Popov, Melissa M. Bowker-Kinley, Robert B. Sloan, Robert A. Harris, Jean A. Hamilton   +5 more
openaire   +1 more source

Nutritional Potential, Phytochemical Content, In Vivo Antioxidant, and Antanemic Potential of Musa paradisiaca Flower

Food Chemistry International, EarlyView.
After collecting Musa paradisiaca leaves, some were dried and others were used to produce aqueous extracts. The extracts and powders were characterized and then administered to rats made anaemic by PHZ. After 14 days of administration of the two samples, the rats were euthanized and it was observed that after 9 days of treatment, the aqueous extract ...
Josée Rebeca Nombo, Jethro Roland Misse Ngangue Ekwala, Somon Régine Tuem, Stéphano Tene Tambo, Merlin Ngafon Nchoutpouen, Valery Jean François Nsoga, Jules Christophe Koule Manz, Jordan Mekui Nwotue, Mathieu Ndomou   +8 more
wiley   +1 more source

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.

Cell Metabolism, 2006
Jung-whan Kim, Irina Tchernyshyov, G. Semenza, C. Dang   +3 more
semanticscholar   +1 more source

Targeting pyruvate metabolism generates distinct CD8+ T cell responses to gammaherpesvirus and B lymphoma

JCI Insight
T cells rely on different metabolic pathways to differentiate into effector or memory cells, and metabolic intervention is a promising strategy to optimize T cell function for immunotherapy.
Taewook Kang, Young-Kwang Usherwood, Julie A. Reisz, Sukrut C. Kamerkar, Rachel Culp-Hill, Owen M. Wilkins, Andreia F. Verissimo, Fred W. Kolling IV, Anton M. Hung, Shawn C. Musial, Pamela C. Rosato, Angelo D’Alessandro, Henry N. Higgs, Edward J. Usherwood   +13 more
doaj   +1 more source