Results 161 to 170 of about 168,834 (385)

Effect of diet on linoleic acid desaturation and on some enzymes of carbohydrate metabolism

Journal of Lipid Research, 1970
The effect of diet on the desaturation of linoleic acid to gamma-linolenic acid by liver microsomal preparations, on blood glucose and insulin levels, and on activities of glucokinase, hexokinase, pyruvate kinase, and alpha-glycerophosphate dehydrogenase
I.N. De Gomez Dumm, M.J. De Alaniz, R.R. Brenner   +2 more
doaj  

Role of protein synthesis and of fatty acid metabolism in the longer-term regulation of pyruvate dehydrogenase kinase [PDF]

, 1994
David A. Priestman, Sharad Mistry, Antony Halsall, P J Randle   +3 more
openalex   +1 more source

Innovative PDK1‐Degrading PROTACs Transform Cancer Aerobic Glycolysis and Induce Immunogenic Cell Death in Breast Cancer

Exploration, EarlyView.
In this study, A04, a compound targeting the degradation of metabolic enzyme PDK1, was developed by PROTAC technology, which significantly inhibited tumor proliferation by disrupting the Warburg effect in cancer cells. In the mouse model, A04 could prolong postoperative survival, and also remodel the immunosuppressive microenvironment, which could ...
Aohua Deng, Renming Fan, Jiakui Gou, Ruoxi Sang, Ruizhuo Lin, Ting Zhao, Junyan Zhuang, Yongrui Hai, Jialin Sun, Gaofei Wei   +9 more
wiley   +1 more source

Pathogenic mechanisms underlying X-linked Charcot-Marie-Tooth neuropathy (CMTX6) in patients with a pyruvate dehydrogenase kinase 3 mutation

Neurobiology of Disease, 2016
Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral neuropathy. An X-linked form of CMT (CMTX6) is caused by a missense mutation (R158H) in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.
Gonzalo Perez-Siles, Carolyn Ly, Adrienne Grant, Alexander P. Drew, Eppie M. Yiu, Monique M. Ryan, David T. Chuang, Shih-Chia Tso, Garth A. Nicholson, Marina L. Kennerson   +9 more
doaj  

Orexin A affects HepG2 human hepatocellular carcinoma cells glucose metabolism via HIF-1α-dependent and -independent mechanism.

PLoS ONE, 2017
Orexins are hypothalamic neuropeptides that regulate feeding, reward, wakefulness and energy homeostasis. The present study sought to characterize the involvement of orexin A in glucose metabolism in HepG2 human hepatocellular carcinoma cells, and ...
Xing Wan, Yuanyuan Liu, Yuyan Zhao, Xiaoqi Sun, Dongxiao Fan, Lei Guo   +5 more
doaj   +1 more source

Pyruvate dehydrogenase kinase regulates macrophage polarization in metabolic and inflammatory diseases. [PDF]

Front Immunol, 2023
Li C, Liu C, Zhang J, Lu Y, Jiang B, Xiong H, Li C.   +6 more
europepmc   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Targeting enzyme sites in pyruvate kinase, glutamate dehydrogenase and glutathione S-transferase [PDF]

, 1994
Roberta F. Colman
openalex   +1 more source

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.

Journal of Medicinal Chemistry, 2017
Pyruvate dehydrogenase kinases 1-4 (PDK1-4) negatively control activity of the pyruvate dehydrogenase complex (PDC) and are up-regulated in obesity, diabetes, heart failure, and cancer.
S. Tso, Mingliang Lou, Cheng-Yang Wu, W. Gui, J. Chuang, Lorraine K. Morlock, N. Williams, R. M. Wynn, Xiangbing Qi, D. Chuang   +9 more
semanticscholar   +1 more source

Alpha‐Lipoic Acid Alleviates Isoflurane‐Induced Cognitive Dysfunction in Juvenile Mice by Activating Peroxisome Proliferator Activated Receptor Gamma Coactivator ‐1 Alpha

Food Frontiers, EarlyView.
Alpha‐lipoic acid (ALA) plays a significant role in alleviating isoflurane‐induced cognitive dysfunction in juvenile mice by activating PGC‐1α, which improves mitochondrial function and energy metabolism in astrocytes. As a potent antioxidant, ALA is commonly found in foods like spinach, broccoli, and yeast, and its supplementation may offer ...
Xingkai Zhao, Donglu Wang, Shuai Li, Xueting Zhang, Zhenlei Zhou   +4 more
wiley   +1 more source