Results 161 to 170 of about 68,490 (304)

Anti-Metastatic Effect of Pyruvate Dehydrogenase Kinase 4 Inhibition in Bladder Cancer via the ERK, SRC, and JNK Pathways. [PDF]

Int J Mol Sci, 2022
Lee EH, Chung JW, Sung E, Yoon BH, Jeon M, Park S, Chun SY, Lee JN, Kim BS, Kim HT, Kim TH, Choi SH, Yoo ES, Kwon TG, Kang HW, Kim WJ, Yun SJ, Lee S, Ha YS.   +18 more
europepmc   +1 more source

Insights Into the Conformational Dynamics of the Cytoplasmic Domain of Metal‐Sensing Sensor Histidine Kinase ZraS

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT ZraS is a metal sensor integral to ZraPSR, a two‐component signaling system found in enterobacters. It belongs to a family of bifunctional sensor histidine kinases (SHKs) and is speculated to sense zinc‐induced stress on the bacterial envelope.
Nilima Mahapatra, Pranjal Mahanta, Shubhant Pandey, Rudresh Acharya   +3 more
wiley   +1 more source

Promotive role of eukaryotic translation initiation factor 4A isoform 3 in ovarian cancer cell growth and aerobic glycolysis through the pyruvate dehydrogenase kinase 4 signaling. [PDF]

Kaohsiung J Med Sci, 2023
Bai SS, Yan LW, Liu CH.
europepmc   +1 more source

Yeast Pyruvate Dehydrogenase Complex Is Regulated by a Concerted Activity of Two Kinases and Two Phosphatases [PDF]

, 2008
Uta Gey, Cornelia Czupalla, Bernard Hoflack, Gerhard Rödel, Udo Krause‐Buchholz   +4 more
openalex   +1 more source

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

Small Science, EarlyView.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang   +4 more
wiley   +1 more source

Induction of Pyruvate Dehydrogenase Kinase-3 by Hypoxia-inducible Factor-1 Promotes Metabolic Switch and Drug Resistance [PDF]

, 2008
Chun-Wun Lu, Shih‐Chieh Lin, Ko‐Fan Chen, Yen-Yu Lai, Shaw‐Jenq Tsai   +4 more
openalex   +1 more source

Differential gene expression in Chorthippus parallelus (Zetterstedt, 1821) (Orthoptera: Acrididae: Gomphocerinae) induced by Wolbachia infection

Insect Science, EarlyView.
Distinct lineages of the grasshopper Chorthippus parallelus (Orthoptera: Acrididae) form a well‐known hybrid zone (HZ) in the Pyrenees mountain range; the Iberian endemism C. p. erythropus (Cpe) and the subspecies C. p. parallelus, (Cpp) widely distributed throughout the rest of Europe. Both subspecies differ in diverse traits, including the strains of
Patricia Jiménez‐Florido, Mónica Aquilino, David Buckley, José L. Bella, Rosario Planelló   +4 more
wiley   +1 more source

Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma. [PDF]

Front Oncol, 2021
Kuo YH, Chan TC, Lai HY, Chen TJ, Wu LC, Hsing CH, Li CF.   +6 more
europepmc   +1 more source

Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age

Aging Cell, EarlyView.
Human skin fibroblasts in vitro preserve the memory of age and health. ABSTRACT Aging leads to a decline in physiological reserves, an increase in age‐related diseases, reduced functional ability and a shortened healthspan. While molecular markers of chronological aging exist, their link to general health and intrinsic capacity (IC), a composite ...
Chloé Brodeau, Camille Joly, Anaïs Chekroun, Jean Nakhle, Vincent Blase, Nicolas Espagnolle, Cédric Dray, Armelle Yart, Valérie Planat, Margot Tertrais, Julien Fassy, Sophie Guyonnet, Wan‐Hsuan Lu, Philipe de Souto Barreto, Olivier Teste, Marie Tremblay‐Franco, Kamaryn T. Tanner, Alan A. Cohen, Audrey Carriere, Louis Casteilla, Isabelle Ader, IHU HealthAge/Open Science group   +21 more
wiley   +1 more source

Inhibition of ROS1 activity with lorlatinib reversibly suppresses fertility in male mice

Andrology, EarlyView.
Abstract Background Inhibition of sperm maturation in the epididymis is a promising post‐testicular strategy for short‐acting male contraceptives. It has been shown that ROS1, a receptor tyrosine kinase expressed in the epididymis, is essential for epididymal differentiation, sperm maturation, and male fertility in mice.
Yuki Oyama, Kentaro Shimada, Haruhiko Miyata, Rie Iida‐Norita, Chihiro Emori, Maki Kamoshita, Seiya Oura, Ryohei Katayama, Martin M. Matzuk, Masahito Ikawa   +9 more
wiley   +1 more source