Aging Cell, Volume 24, Issue 4, April 2025.A schematic depiction of chlorogenic acid inhibited UVA‐induced cellular senescence and mouse skin photoaging by suppressing the activity of Enolase 1 (ENO1) protein to block glycolytic pathway. Abstract Cellular senescence plays a critical role in repeated ultraviolet (UV) exposure‐induced skin photoaging. Currently, from the perspective of regulating
Xueling He +11 more
wiley +1 more source
Global Metabolic Shifts in Age and Alzheimer's Disease Mouse Brains Pivot at NAD+/NADH Redox Sites. [PDF]
, 2019 Age and Alzheimer's disease (AD) share some common features such as cognitive impairments, memory loss, metabolic disturbances, bioenergetic deficits, and inflammation.
Brewer, Gregory J, Dong, Yue
core
Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex [PDF]
, 2005 Masato Kato +4 more
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Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures
Aging Cell, Volume 24, Issue 5, May 2025.Longevity humans have “a youthful erythrocyte function and metabolism” with a youth‐like oxygen release and anti‐oxidative capability to combat tissue hypoxia and improve healthspan. ABSTRACT Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging‐related diseases.
Fang Yu +17 more
wiley +1 more source
Cobalt-conjugated carbon quantum dots for in vivo monitoring of the pyruvate dehydrogenase kinase inhibitor drug dichloroacetic acid. [PDF]
Sci Rep, 2022 Raut J +7 more
europepmc +1 more source
Determination of Purine Nucleoside Diphosphate by use of Pyruvate Kinase and Lactate Dehydrogenase.
, 1995 Hiroshi Shimofuruya +3 more
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The Carboxy-Terminal Tail of Pyruvate Dehydrogenase Kinase 2 Is Required for the Kinase Activity [PDF]
, 2005 Alla Klyuyeva +2 more
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Aging Cell, Volume 24, Issue 4, April 2025.Adequate NADK/NADK2 level is essential to the proper functioning of redox and folate cycles and the purine biosynthesis pathway, and as well as maintenance of GSIS response. During aging, diminished NADK/NADK2 expression alters the metabolic status quo, increasing AICAR production. The latter activates AMPK and suppresses GSIS.
Guan‐Jie Li +6 more
wiley +1 more source
Elevated Level of Cerebrospinal Fluid Pyruvate Dehydrogenase Kinase 4 Is a Predictive Biomarker of Clinical Outcome after Subarachnoid Hemorrhage. [PDF]
Brain Sci, 2022 Gao X, Zhang H, Peng Z, Zhuang Z, Li W.
europepmc +1 more source
Aging Cell, EarlyView.The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai +7 more
wiley +1 more source