Results 211 to 220 of about 181,145 (327)

Anti-Metastatic Effect of Pyruvate Dehydrogenase Kinase 4 Inhibition in Bladder Cancer via the ERK, SRC, and JNK Pathways. [PDF]

Int J Mol Sci, 2022
Lee EH, Chung JW, Sung E, Yoon BH, Jeon M, Park S, Chun SY, Lee JN, Kim BS, Kim HT, Kim TH, Choi SH, Yoo ES, Kwon TG, Kang HW, Kim WJ, Yun SJ, Lee S, Ha YS.   +18 more
europepmc   +1 more source

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

Targeting cancer metabolism through p-cresol mediated Inhibition of pyruvate dehydrogenase kinase 3 in lung cancer. [PDF]

Sci Rep
Ashames A, Anwar S, Sulaimani MN, Pinky, Khan MS, Shahwan M, Parvez S, Hassan MI, Dinislam K, Shamsi A.   +9 more
europepmc   +1 more source

Promotive role of eukaryotic translation initiation factor 4A isoform 3 in ovarian cancer cell growth and aerobic glycolysis through the pyruvate dehydrogenase kinase 4 signaling. [PDF]

Kaohsiung J Med Sci, 2023
Bai SS, Yan LW, Liu CH.
europepmc   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

Toxicology of atmospheric degradation products of selected hydrochlorofluorocarbons [PDF]

Trifluoroacetic acid (TFA) is a liquid with a sharp biting odor. It has been proposed as the product of environmental degradation of the hydrochlorofluorocarbons HCFC-123, HCFC-124, HFC-134a, and HFC-125.
Kaminsky, Laurence S.
core   +1 more source

Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma. [PDF]

Front Oncol, 2021
Kuo YH, Chan TC, Lai HY, Chen TJ, Wu LC, Hsing CH, Li CF.   +6 more
europepmc   +1 more source

Myocardial pyruvate dehydrogenase kinase 4 drives sex-specific cardiac responses to endotoxemia. [PDF]

JCI Insight
Yap JQ, Nikouee A, Kim M, Cao Q, Rademacher DJ, Lau JE, Arora A, Zou LY, Sun Y, Szweda L, Sadek H, Elliot S, Roos B, Glassberg MK, Ji HL, Gao X, Dong Q, Zang QS.   +17 more
europepmc   +1 more source

Body size of male Atlantic salmon (Salmo salar L.) at introduction of a 5‐week LD12:12 winter signal influences their decision to mature early or smoltify

Journal of Fish Biology, EarlyView.
Abstract Sexual maturation of male Atlantic salmon post‐smolts (‘jacking’) is undesired in aquaculture and seems to occur due to the intensification in modern facilities. Maturation depends on internal and external factors (temperature, photoperiod, feed availability, energy levels, body size, genetic background) that act on the brain‐pituitary‐gonad ...
Enrique Pino‐Martinez, Kristine F. Staveland, Mitchell S. Fleming, Pablo Balseiro, Cindy Pedrosa, Sigurd O. Handeland   +5 more
wiley   +1 more source

NF-κB activation as a pro-survival signal from pharmacological inhibition of pyruvate dehydrogenase kinase 1 in non-small-cell lung carcinoma cell models. [PDF]

Transl Oncol
Liu Q, Ran M, Shan W, Zhang SL, Tam KY.
europepmc   +1 more source