Results 251 to 260 of about 168,834 (385)

TIME COURSE OF A 40 HOUR FAST ON PYRUVATE DEHYDROGENASE ACTIVATION AND KINASE EXPRESSION IN HUMAN SKELETAL MUSCLE

, 2001
L. L. Spriet, Rebecca J. Tunstall, Matthew J. Watt, Mark Hargreaves, David Cameron‐Smith   +4 more
openalex   +1 more source

Regulation of Pyruvate Dehydrogenase Kinase 4 (PDK4) by Thyroid Hormone [PDF]

, 2009
Ramy R. Attia, Sara Connnaughton, Lindsey R. Boone, Fang Wang, Marshall B. Elam, Gene C. Ness, George A. Cook, Edwards A. Park   +7 more
openalex   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Sodium Phenylbutyrate Attenuates Cisplatin-Induced Acute Kidney Injury Through Inhibition of Pyruvate Dehydrogenase Kinase 4. [PDF]

Biomedicines
Oh CJ, Choi W, Lee HY, Lee IK, Kim MJ, Jeon JH.   +5 more
europepmc   +1 more source

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2 [PDF]

, 2011
Tanupriya Contractor, Chris Harris
openalex   +1 more source

Elucidating the Role and Mechanism of Alpha‐Enolase in Senescent Amelioration via Metabolic Reprogramming

Cell Proliferation, EarlyView.
KB2764 interacted with alpha‐enolase (ENO1) and pyruvate kinase M (PKM), ultimately leading to PKM phosphorylation of ENO1. KB2764 consequently increased mitochondrial ATP production and decreased glycolysis dependence. Furthermore, the action of KB2764 extends its application to extend the lifespan of Caenorhabditis elegans.
Yun Haeng Lee, Hyunwoong Lim, Gyungmin Kim, Geonhee Jang, Myeong Uk Kuk, Ji Ho Park, Jee hee Yoon, Yoo Jin Lee, Duyeol Kim, Byeonghyeon So, Minseon Kim, Hyung Wook Kwon, Youngjoo Byun, Joon Tae Park   +13 more
wiley   +1 more source

Endurance training and pyruvate dehydrogenase kinase 4 (PDK4) inhibition combination is superior to each one alone in attenuating hyperketonemia/ketoacidosis in diabetic rats. [PDF]

Iran J Basic Med Sci
Rezaeinasab H, Habibi A, Rezaei R, Basereh A, Reverentia Yurista S, Khoramipour K.   +5 more
europepmc   +1 more source

Human Umbilical Cord Mesenchymal Stem Cells Protect against Renal Ischemia-Reperfusion Injury by Secreting Extracellular Vesicles Loaded with miR-148b-3p That Target Pyruvate Dehydrogenase Kinase 4 to Inhibit Endoplasmic Reticulum Stress at the Reperfusion Stages. [PDF]

Int J Mol Sci, 2023
Shi W, Zhou X, Li X, Peng X, Chen G, Li Y, Zhang C, Yu H, Feng Z, Gou X, Fan J.   +10 more
europepmc   +1 more source

Regulation of Pyruvate Dehydrogenase Kinase 4 (PDK4) by CCAAT/Enhancer-binding Protein β (C/EBPβ) [PDF]

, 2011
Ramy R. Attia, Pragya Sharma, Rachel C. Janssen, Jacob E. Friedman, Xiong Deng, Jae‐Seung Lee, Marshall B. Elam, George A. Cook, Edwards A. Park   +8 more
openalex   +1 more source

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

European Journal of Clinical Investigation, EarlyView.
This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone, Jean‐Pierre Després, John P. A. Ioannidis, Ian J. Neeland, Gabriella Garruti, Luca Busetto, Luca Liberale, Stefano Ministrini, Gemma Vilahur, Thomas H. Schindler, Maria Paula Macedo, Agostino Di Ciaula, Marcin Krawczyk, Andreas Geier, Gyorgy Baffy, Maria Felicia Faienza, Ilaria Farella, Nicola Santoro, Gema Frühbeck, Patricia Yárnoz‐Esquiroz, Javier Gómez‐Ambrosi, Emma Chávez‐Manzanera, Verónica Vázquez‐Velázquez, Jean‐Michel Oppert, Dimitrios N. Kiortsis, Paolo Sbraccia, Carmine Zoccali, Piero Portincasa, Fabrizio Montecucco   +28 more
wiley   +1 more source