Results 261 to 270 of about 168,834 (385)

Inhibition of the ubiquitin-proteasome system reduces the abundance of pyruvate dehydrogenase kinase 1 in cultured myotubes. [PDF]

J Muscle Res Cell Motil
Kociper B, Škorja Milić N, Ogrizek I, Miš K, Pirkmajer S.   +4 more
europepmc   +1 more source

Farnesoid X Receptor Deficiency Induces Hepatic Lipid and Glucose Metabolism Disorder via Regulation of Pyruvate Dehydrogenase Kinase 4. [PDF]

Oxid Med Cell Longev, 2022
Deng W, Fan W, Tang T, Wan H, Zhao S, Tan Y, Oware KA, Tan J, Li J, Qu S.   +9 more
europepmc   +1 more source

Glycaemic sugar metabolism and the gut microbiota: past, present and future

The FEBS Journal, Volume 292, Issue 6, Page 1421-1436, March 2025.
Increased sugar consumption is a main driver of the increased prevalence of obesity and non‐communicable diseases (NCDs). Therefore, understanding host and microbial sugar metabolism and its metabolic effects is crucial. A high‐sugar diet can induce gut dysbiosis, and gut microbial sugar fermentation can produce deleterious metabolites, potentially ...
Florine H. M. Westerbeke, Ilias Attaye, Melany Rios‐Morales, Max Nieuwdorp   +3 more
wiley   +1 more source

Investigating Pyruvate Dehydrogenase Kinase 3 Inhibitory Potential of Myricetin Using Integrated Computational and Spectroscopic Approaches. [PDF]

ACS Omega
Anwar S, Khan S, Hussain A, Alajmi MF, Shamsi A, Hassan MI.   +5 more
europepmc   +1 more source

Retinoic acid regulates pyruvate dehydrogenase kinase 4 (Pdk4) to modulate fuel utilization in the adult heart: Insights from wild-type and β-carotene 9',10' oxygenase knockout mice. [PDF]

FASEB J, 2022
Holloway C, Zhong G, Kim YK, Ye H, Sampath H, Hammerling U, Isoherranen N, Quadro L.   +7 more
europepmc   +1 more source

Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle [PDF]

, 2012
Rita Rinnankoski‐Tuikka, Mika Silvennoinen, Sira Torvinen, Juha J. Hulmi, Maarit Lehti, Riikka Kivelä, Hilkka Reunanen, Heikki Kainulainen   +7 more
openalex   +1 more source

Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism

The FEBS Journal, Volume 292, Issue 8, Page 2017-2050, April 2025.
SUCNR1, activated by succinate, is a Gi‐ and Gq‐coupled receptor present at the plasma membrane and in endosomes. There are conflicting reports about the pro‐/anti‐inflammatory effects of the succinate‐SUCNR1 signaling axis, and these are likely due to localization‐dependent signaling.
Aenne‐Dorothea Liebing, Philipp Rabe, Petra Krumbholz, Christian Zieschang, Franziska Bischof, Angela Schulz, Susan Billig, Claudia Birkemeyer, Thanigaimalai Pillaiyar, Mikel Garcia‐Marcos, Robert Kraft, Claudia Stäubert   +11 more
wiley   +1 more source

Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate Improves Host Control of Salmonella enterica Serovar Typhimurium Infection in Human Macrophages. [PDF]

Front Immunol, 2021
van Doorn CLR, Schouten GK, van Veen S, Walburg KV, Esselink JJ, Heemskerk MT, Vrieling F, Ottenhoff THM.   +7 more
europepmc   +1 more source

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

The FEBS Journal, EarlyView.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler, Muhammad I. Abeer, Sanaz Arezoumandan, Keyshawn Cox, Tyler L. Petersen, Esther H. Daniel, Carlton L. Cannon III, Angelica Bautista, Kennedy D. Blancher, Alysia M. Bland, Kylie J. Bond, Dominque A. Davis, Jessica M. Francois, Eliana J. McCray, Justin M. Morgan, Jessica L. Pulliam, Zymir A. Robinson, Mykia J. Taylor, James A. Dowell, Nigel J. Cairns, Michael A. Gitcho   +20 more
wiley   +1 more source

An enzyme-mimicking reactive oxygen species scavenger targeting oxidative stress-inflammation cycle ameliorates IR-AKI by inhibiting pyruvate dehydrogenase kinase 4. [PDF]

Theranostics
He W, Ding C, Lin T, Wang B, Wang W, Deng Z, Jin T, Shang Y, Zheng D, Bai T, Zhang M, Li R, Jin J, He Q.   +13 more
europepmc   +1 more source