Results 51 to 60 of about 181,145 (327)
Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]
, 2011 Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez +2 more
core +2 more sources
Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages
Journal of Molecular Cell Biology, 2020 Interleukin-10 (IL-10) is the most potent anti-inflammatory cytokine in the body and plays an essential role in determining outcomes of many inflammatory diseases.
Y. Na +5 more
semanticscholar +1 more source
Regulation of mammalian pyruvate dehydrogenase kinase [PDF]
FEBS Letters, 1997 It is generally believed that mammalian pyruvate dehydrogenase kinase is a heterodimer consisting of catalytic and regulatory subunits. However, the contribution of the two subunits to the kinase‐mediated signal transduction has remained undefined. In the present study recombinant components of mammalian pyruvate dehydrogenase complex were employed in ...
openaire +2 more sources
Warburg effect hypothesis in autism Spectrum disorders
Molecular Brain, 2018 Autism spectrum disorder (ASD) is a neurodevelopmental disease which is characterized by a deficit in social interactions and communication with repetitive and restrictive behavior. In altered cells, metabolic enzymes are modified by the dysregulation of
Alexandre Vallée, Jean-Noël Vallée
doaj +1 more source
A simple and reliable method for determination of optimum pH in coupled enzyme assays
BioTechniques, 2020 Determination of the optimum pH in a coupled enzyme assay poses significant challenges because altering the pH of the reaction mixture can affect the performance of both enzymes.
Lee Bowman +7 more
doaj +1 more source
Molecular Cancer Therapeutics, 2019 Cancer cells use alterations of normal metabolic processes to sustain proliferation indefinitely. Transcriptional and posttranscriptional control of the pyruvate dehydrogenase kinase (PDK) family is one way in which cancer cells alter normal pyruvate ...
B. Woolbright +3 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2019 Metabolic disturbances have been implicated in demyelinating diseases including multiple sclerosis (MS). Melatonin, a naturally occurring hormone, has emerged as a potent neuroprotective candidate to reduce myelin loss and improve MS outcomes.
Majid Ghareghani +13 more
doaj +1 more source
Detecting de novo Hepatic Ketogenesis Using Hyperpolarized [2-13C] Pyruvate
Frontiers in Physiology, 2022 The role of ketones in metabolic health has progressed over the past two decades, moving from what was perceived as a simple byproduct of fatty acid oxidation to a central player in a multiplicity of disease states. Previous work with hyperpolarized (HP)
Mukundan Ragavan +3 more
doaj +1 more source
Monovalent Cation Activation of Plant Pyruvate Dehydrogenase Kinase [PDF]
Plant Physiology, 1993 The pyruvate dehydrogenase kinase-catalyzed inactivation of the pyruvate dehydrogenase complex was studied using dialyzed, soluble proteins from mitochondria purified from green leaf tissue of Pisum sativum L. seedlings. At subsaturating ATP concentrations, K+ or NH4+, but not Na+, stimulated the pyruvate dehydrogenase kinase by lowering the Km(ATP ...
K. A., Schuller +2 more
openaire +2 more sources
Hypoxic state and glycolysis as a possible anticancer therapeutic target
Успехи молекулярной онкологии, 2015 In this review the role of hypoxia and glycolysis in tumor expansion is described. Experimental results demonstrate that glycolysis functions in tumor cells are not restrict only energy supply.
V. A. Koblyakov
doaj +1 more source