Results 61 to 70 of about 168,834 (385)

Hypoxic state and glycolysis as a possible anticancer therapeutic target

Успехи молекулярной онкологии, 2015
In this review the role of hypoxia and glycolysis in tumor expansion is described. Experimental results demonstrate that glycolysis functions in tumor cells are not restrict only energy supply.
V. A. Koblyakov
doaj   +1 more source

Structure of Pyruvate Dehydrogenase Kinase [PDF]

Journal of Biological Chemistry, 2001
The structure of mitochondrial pyruvate dehydrogenase kinase isozyme 2 is of interest because it represents a family of serine-specific protein kinases that lack sequence similarity with all other eukaryotic protein kinases. Similarity exists instead with key motifs of prokaryotic histidine protein kinases and a family of eukaryotic ATPases.
Robert A. Harris, Kirill M. Popov, Melissa M. Bowker-Kinley, C. Nicklaus Steussy, Jean A. Hamilton, Robert B. Sloan   +5 more
openaire   +2 more sources

Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development. [PDF]

, 2011
Label-free LC-MS/MS-based shot-gun proteomics was used to quantify the differential protein synthesis and metabolite profiling in order to assess metabolic changes during the development of citrus fruits.
Blumwald, Eduardo, Boo, Kyung Hwan, Eigenheer, Richard A, Katz, Ehud, Kim, Ho Youn, Negre-Zakharov, Florence, Phinney, Brett S, Sadka, Avi, Shulaev, Vladimir   +8 more
core   +3 more sources

Modification of pyruvate kinase and lactate dehydrogenase in foot muscle of the sea mussel Mytilus galloprovincialis under anaerobiosis and recovery

Brazilian Journal of Medical and Biological Research, 1997
The modification of pyruvate kinase (PK) and lactate dehydrogenase (LDH) activity in foot muscle of the mussel Mytilus galloprovincialis during exposure to air and recovery in water was investigated.
V.I. Lushchak, T.V. Bahnjukova, A.V. Spichenkov   +2 more
doaj   +1 more source

Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype

Frontiers in Immunology, 2019
Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits the pyruvate dehydrogenase-mediated conversion of ...
Byong-Keol Min, Sungmi Park, Hyeon-Ji Kang, Dong Wook Kim, H. Ham, Chae-Myeong Ha, Byung-Jun Choi, Jung Yi Lee, C. J. Oh, E. Yoo, Hui Eon Kim, Byung-Gyu Kim, Jae-Han Jeon, Do Young Hyeon, D. Hwang, Yong-Hoon Kim, Chul-Ho Lee, Taeho Lee, Jung-whan Kim, Yeon-Kyung Choi, K. Park, A. Chawla, Jongsoon Lee, Robert A. Harris, In-kyu Lee   +24 more
semanticscholar   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

High yield 1,3-propanediol production by rational engineering of the 3-hydroxypropionaldehyde bottleneck in Citrobacter werkmanii [PDF]

, 2016
Background: Imbalance in cofactors causing the accumulation of intermediates in biosynthesis pathways is a frequently occurring problem in metabolic engineering when optimizing a production pathway in a microorganism.
Avcı, Fatma Gizem, Beauprez, Joeri, De Maeseneire, Sofie, De Mey, Marjan, Maervoet, Veerle, Soetaert, Wim   +5 more
core   +3 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Diversity of the pyruvate dehydrogenase kinase gene family in humans. [PDF]

Journal of Biological Chemistry, 1995
Recent evidence from this laboratory indicates that at least two isoenzymic forms of pyruvate dehydrogenase kinase (PDK1 and PDK2) may be involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase complex by phosphorylation (Popov, K.M., Kedishvili, N.Y., Zhao, Y., Gudi, R., and Harris, R.A. (1994) J. Biol. Chem.
Kirill M. Popov, Melissa M. Bowker-Kinley, Yu Zhao, Natalia Y. Kedishvili, Ramadevi Gudi   +4 more
openaire   +4 more sources

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source