Results 61 to 70 of about 181,145 (327)

Artificial Photosynthesis Would Unify the Electricity-Carbohydrate-Hydrogen Cycle for Sustainability [PDF]

open access: yes, 2010
Sustainable development requires balanced integration of four basic human needs – air (O2/CO2), water, food, and energy. To solve key challenges, such as CO2 fixation, electricity storage, food production, transportation fuel production, water ...
Yi-Heng Percival Zhang
core   +2 more sources

Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype

open access: yesFrontiers in Immunology, 2019
Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits the pyruvate dehydrogenase-mediated conversion of ...
Byong-Keol Min   +24 more
semanticscholar   +1 more source

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications [PDF]

open access: yesBioscience Reports, 2021
Abstract Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it further links glycolysis with the tricarboxylic acid cycle and ATP generation.
Xiuxiu Wang   +3 more
openaire   +2 more sources

Pyruvate Dehydrogenase and Pyruvate Dehydrogenase Kinase Expression in Non Small Cell Lung Cancer and Tumor-Associated Stroma

open access: yesNeoplasia: An International Journal for Oncology Research, 2005
Pyruvate dehydrogenase (PDH) catalyzes the conversion of pyruvate to acetyl-coenzyme A, which enters into the Krebs cycle, providing adenosine triphosphate (ATP) to the cell.
Michael I. Koukourakis   +4 more
doaj   +1 more source

Pyruvate dehydrogenase kinase regulates hepatitis C virus replication [PDF]

open access: yesScientific Reports, 2016
AbstractDuring replication, hepatitis C virus (HCV) utilizes macromolecules produced by its host cell. This process requires host cellular metabolic reprogramming to favor elevated levels of aerobic glycolysis. Therefore, we evaluated whether pyruvate dehydrogenase kinase (PDK), a mitochondrial enzyme that promotes aerobic glycolysis, can regulate HCV ...
Gwon-Soo Jung   +12 more
openaire   +4 more sources

Modification of pyruvate kinase and lactate dehydrogenase in foot muscle of the sea mussel Mytilus galloprovincialis under anaerobiosis and recovery

open access: yesBrazilian Journal of Medical and Biological Research, 1997
The modification of pyruvate kinase (PK) and lactate dehydrogenase (LDH) activity in foot muscle of the mussel Mytilus galloprovincialis during exposure to air and recovery in water was investigated.
V.I. Lushchak   +2 more
doaj   +1 more source

HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium [PDF]

open access: yes, 2013
Background: While acute lung injury (ALI) contributes significantly to critical illness, it resolves spontaneously in many instances. The majority of patients experiencing ALI require mechanical ventilation.
Bonney, Megan   +9 more
core   +3 more sources

Long-term regulation of pyruvate dehydrogenase complex. Evidence that kinase-activator protein (KAP) is free pyruvate dehydrogenase kinase [PDF]

open access: yesBiochemical Journal, 1991
The kinase-activator protein (KAP) of pyruvate dehydrogenase complex (PDC) has been purified approx. 2250-fold from high-speed supernatants of mitochondrial extracts from the liver of 48 h-starved rats. Purified KAP demonstrates kinase activity towards both the E1 component of PDC and towards a synthetic peptide corresponding to the major ...
B S, Jones, S J, Yeaman
openaire   +2 more sources

Fluorometric procedures for measuring triglyceride concentrations in small amounts of tissue and plasma.

open access: yesJournal of Lipid Research, 1988
It has been previously shown that triglycerides can be specifically hydrolyzed by lipase from Rhizopus arrhizus in the presence of hog liver esterase and sodium dodecyl sulfate.
P M Nemeth   +3 more
doaj   +1 more source

A fluorometric method for the assay of protein kinase activity [PDF]

open access: yes, 2018
Protein kinases constitute one of the largest protein families in nature. Current methods to assay their activity involve the use of radioactive ATP or very expensive reagents.
Figueroa, Carlos Maria   +4 more
core   +1 more source

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