Results 81 to 90 of about 168,834 (385)

Theoretical Analysis of the Built-in Metabolic Pathway Effect on the Metabolism of Erythrocyte-Bioreactors That Neutralize Ammonium

Metabolites, 2021
The limitations of the efficiency of ammonium-neutralizing erythrocyte-bioreactors based on glutamate dehydrogenase and alanine aminotransferase reactions were analyzed using a mathematical model.
Evgeniy Protasov, Larisa Koleva, Elizaveta Bovt, Fazoil I. Ataullakhanov, Elena Sinauridze   +4 more
doaj   +1 more source

MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer

Cell Death and Disease, 2018
Increasing evidence indicates that dysregulation of microRNAs (miRNAs) plays a crucial role in human malignancies. Here, we showed that microRNA-422a (miR-422a) expression was dramatically downregulated in gastric cancer (GC) samples and cell lines ...
Zhongyuan He, Zheng Li, Xuan Zhang, Kai Yin, Weizhi Wang, Zhi-xiu Xu, Bowen Li, Lei Zhang, Jianghao Xu, G. Sun, Lu Wang, Qing Li, Xiaoxu Huang, Lu Zhang, Diancai Zhang, Hao Xu, Zekuan Xu   +16 more
semanticscholar   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4

Nature Communications, 2020
Dysregulation of N6-Methyladenosine (m6A) is associated with cancer progression. Here, authors show that m6A methylation of pyruvate dehydrogenase kinase 4 (PDK4) positively regulates its mRNA stability and translation, and consequently affects ...
Zihan Li, Yanxi Peng, Jiexin Li, Zhuojia Chen, Feng Chen, Jian Tu, Shuibin Lin, Hongsheng Wang   +7 more
doaj   +1 more source

Reversing tozasertib resistance in glioma through inhibition of pyruvate dehydrogenase kinases

Molecular Oncology, 2022
Acquired resistance to conventional chemotherapeutic agents limits their effectiveness and can cause cancer treatment to fail. Because enzymes in the aurora kinase family are vital regulators of several mitotic events, we reasoned that targeting these ...
Esther P. Jane, Daniel R. Premkumar, Dhivyaa Rajasundaram, Swetha Thambireddy, Matthew C. Reslink, Sameer Agnihotri, Ian F. Pollack   +6 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins. [PDF]

PLoS ONE, 2015
Shc proteins interact with the insulin receptor, indicating a role in regulating glycolysis. To investigate this idea, the activities of key glycolytic regulatory enzymes and metabolites levels were measured in skeletal muscle from mice with low levels ...
Kevork Hagopian, Alexey A Tomilov, Kyoungmi Kim, Gino A Cortopassi, Jon J Ramsey   +4 more
doaj   +1 more source

miR‐128‐3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1

IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2019
Glioma, like most cancers, possesses a unique bioenergetic state of aerobic glycolysis known as the Warburg effect, which is a dominant phenotype of most tumor cells.
Changda Qu, Chang-sheng Yan, Weifan Cao, Fangqin Li, Yewei Qu, Kelei Guan, Chengqing Si, Ze Yu, Zhangyi Qu   +8 more
semanticscholar   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection. [PDF]

, 2015
BackgroundFruit flies and mammals protect themselves against infection by mounting immune and metabolic responses that must be balanced against the metabolic needs of the pathogens.
Aguirre, Alejandro, Cheung, Kong, Drexler, Anna, Eigenheer, Richard, Giulivi, Cecilia, Glennon, Elizabeth KK, Klyver, John M, Lewis, Edwin E, Luckhart, Shirley, Napoli, Eleonora, Pakpour, Nazzy, Phinney, Brett S, Surachetpong, Win, Wang, Bo   +13 more
core   +1 more source