Results 81 to 90 of about 132,382 (284)

Coupling Nitrogenous Organic Wastewater Treatment and Biorefinery via N‐Cycling Bacterium

Advanced Science, EarlyView.
The vast reservoir of nitrogenous organic pollutants in industrial wastewaters can serve as untapped carbon‐nitrogen resources. This study employs the newly discovered Paracoccus sp. ZQW‐1 as a versatile chassis to simultaneously achieve N‐methylpyrrolidone (NMP) wastewater depuration and polyhydroxybutyrate (PHB) synthesis.
Ziqian Wang, Chunyu Du, Guanyu Zheng, Dahu Ding   +3 more
wiley   +1 more source

Pyruvate Dehydrogenase Kinase as a Novel Therapeutic Target in Oncology

Frontiers in Oncology, 2013
Current drug development in oncology is non-selective as it typically focuses on pathways essential for the survival of all dividing cells. The unique metabolic profile of cancer, which is characterized by increased glycolysis and suppressed ...
Gopinath eSutendra, Evangelos D. Michelakis   +1 more
doaj   +1 more source

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications [PDF]

, 2021
Xiuxiu Wang, Xiaoyue Shen, Yuting Yan, Hongmin Li   +3 more
openalex   +1 more source

In vivo metabolic imaging of Traumatic Brain Injury. [PDF]

, 2017
Complex alterations in cerebral energetic metabolism arise after traumatic brain injury (TBI). To date, methods allowing for metabolic evaluation are highly invasive, limiting our understanding of metabolic impairments associated with TBI pathogenesis ...
Chaumeil, Myriam M, Chou, Austin, Feng, Xi, Guglielmetti, Caroline, Krukowski, Karen, Najac, Chloe, Riparip, Lara-Kirstie, Rosi, Susanna   +7 more
core   +2 more sources

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Combined Treatment With Dichloroacetic Acid and Pyruvate Reduces Hippocampal Neuronal Death After Transient Cerebral Ischemia

Frontiers in Neurology, 2018
Transient cerebral ischemia (TCI) occurs when blood flow to the brain is ceased or dramatically reduced. TCI causes energy depletion and oxidative stress, which leads to neuronal death and cognitive impairment.
Dae Ki Hong, A Ra Kho, Bo Young Choi, Song Hee Lee, Jeong Hyun Jeong, Sang Hwon Lee, Kyoung-Ha Park, Jae-Bong Park, Sang Won Suh   +8 more
doaj   +1 more source

Effects of Low pH on Lactate Dehydrogenase Kinetics of Diving and Nondiving Reptiles [PDF]

, 1986
The properties of lactate dehydrogenase were examined in two snake species, Nerodia rhombifera and Elaphe obsoleta, and a turtle species, Pseudemys scripta.
Baeyens, Dennis A., Hurley, Salim R.
core   +2 more sources

5′tRF‐GlyGCC Promotes Breast Cancer Progression via LDHA‐Mediated Glycolysis and Macrophage Polarization

Advanced Science, EarlyView.
5’tRF‐GlyGCC promotes breast cancer malignancy by binding to LDHA. This interaction, facilitated by FGFR1 and LDHA phosphorylation, enhances glycolysis. Additionally, 5’tRF‐GlyGCC/LDHA signaling recruits and polarizes macrophages into a pro‐tumor M2 state via CCL7, thus remodeling the tumor microenvironment.
Cheng Yi, Yunqing Lu, Xing Chang, Ying Wang, Jiawang Zhou, Guoyou Xie, Lijun Tao, Zhaotong Wang, Yifan Tian, Lihong Wang, Feng Tang, Yijing Zheng, Xinchen Yue, Jinping Lei, Xiansong Wang, Lichen Ge, Zhuojia Chen, Hongsheng Wang   +17 more
wiley   +1 more source

Metabolic aspects of low carbohydrate diets and exercise

Nutrition & Metabolism, 2004
Following a low carbohydrate diet, there is a shift towards more fat and less carbohydrate oxidation to provide energy to skeletal muscle, both at rest and during exercise.
Peters Sandra, LeBlanc Paul
doaj  

The CreC regulator of Escherichia coli, a new target for metabolic manipulations [PDF]

, 2015
The CreBC (carbon source-responsive) two-component regulation system of Escherichia coli affects a number of functions, including intermediary carbon catabolism.
Cabrera Gomez, José Gregorio, Godoy, Manuel Santiago, Nikel, Pablo Ivan, Pettinari, María Julia   +3 more
core   +1 more source