Results 141 to 150 of about 216,078 (374)

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells [PDF]

, 2019
Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secrete adequate levels of insulin. The molecular mechanisms underlying the progressive failure of β-cells to respond to glucose in type-2 diabetes remain ...
A Dobin, A Leyssens, A Liberzon, A Segerstolpe, C Fernandez, C Lochmatter, C Ricordi, C Zhao, CA Dropplemann, E Karra, E Roche, ER Pearson, F Gerst, F Schuit, FM Ashcroft, FM Ashcroft, GC Weir, GH Patterson, I Göhring, J Adam, J Berg, J Cantley, J Hou, J Rahier, JI MacRae, K Eto, K Lemaire, L Marselli, L Väremo, M Aichler, M Anello, M Bensellam, M Prentki, Maria Rohm, MD Robinson, MEJ Lean, MF Brereton, MR Duchen, N Sekine, O Baba, Oram, P Detimary, P Maechler, P Rorsman, P Spegel, PA Halban, RK Benninger, S Lamble, SJ Ashcroft, T Brun, T Brun, T Koeck, TS Blacker, TS Blacker, UK UKPDS., V Behrends, WJ Malaisse, Y Liao   +57 more
core   +3 more sources

SSRP1/SLC3A2 Axis in Arginine Transport: A New Target for Overcoming Immune Evasion and Tumor Progression in Peripheral T‐Cell Lymphoma

Advanced Science, EarlyView.
Enhanced arginine uptake is a critical feature of metabolic reprogramming in PTCL, characterized by elevated expression of the arginine transporter SLC3A2. SLC3A2‐mediated arginine uptake facilitates PTCL proliferation and survival by enhancing OXPHOS metabolism and inducing immune evasion.
Yimin Ren, Lei Fan, Ling Wang, Yanping Liu, Jie Zhang, Boya Wang, Ruize Chen, Xiao Chen, Lingyu Zhuang, Yaping Zhang, Handong Sun, Jianyong Li, Wenyu Shi, Hui Jin   +13 more
wiley   +1 more source

Metabolic responses to pyruvate kinase deletion in lysine producing Corynebacterium glutamicum

Microbial Cell Factories, 2008
Background Pyruvate kinase is an important element in flux control of the intermediate metabolism. It catalyzes the irreversible conversion of phosphoenolpyruvate into pyruvate and is under allosteric control.
Wittmann Christoph, Klopprogge Corinna, Becker Judith   +2 more
doaj   +1 more source

Genome-scale architecture of small molecule regulatory networks and the fundamental trade-off between regulation and enzymatic activity [PDF]

, 2017
Metabolic flux is in part regulated by endogenous small molecules that modulate the catalytic activity of an enzyme, e.g., allosteric inhibition. In contrast to transcriptional regulation of enzymes, technical limitations have hindered the production of ...
Briars, Emma, Christodoulou, Dimitris, Goldford, Joshua E., Noor, Elad, Reznik, Ed, Sauer, Uwe, Segrè, Daniel   +6 more
core   +2 more sources

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun, Yangyang Shi, Chen Yan, Shunmin Wang, Linhui Han, Fudong Li, Ximing Xu, Yuan Wang, Jingchuan Sun, Zijian Kang, Jiangang Shi   +10 more
wiley   +1 more source

Pyruvate kinase deficiency and PKLR gene mutations: Insights from molecular dynamics simulation analysis

Heliyon
Pyruvate kinase deficiency is a rare hereditary erythrocyte enzyme disease caused by mutations in the pyruvate kinase liver and red blood cell gene. The clinical presentations of pyruvate kinase deficiency are significantly heterogeneous, ranging from ...
Yang Wang, Jiaqi Liu, Tao Liu, Xizhou An, Lan Huang, Jiacheng Li, Yongjie Zhang, Yan Xiang, Li Xiao, Weijia Yi, Jiebin Qin, Lili Liu, Cuilan Wang, Jie Yu   +13 more
doaj  

New insights on the mechanism of the K(+-) independent activity of crenarchaeota pyruvate kinases.

PLoS ONE, 2015
Eukarya pyruvate kinases have glutamate at position 117 (numbered according to the rabbit muscle enzyme), whereas in Bacteria have either glutamate or lysine and in Archaea have other residues.
Gustavo De la Vega-Ruíz, Lenin Domínguez-Ramírez, Héctor Riveros-Rosas, Carlos Guerrero-Mendiola, Alfredo Torres-Larios, Gloria Hernández-Alcántara, José J García-Trejo, Leticia Ramírez-Silva   +7 more
doaj   +1 more source

CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation [PDF]

, 2003
CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an important role in adaptive immunity and inflammation.
Callard, R.E., Inwald, D.P., Klein, N.J., McDowall, A., Peters, M.J.   +4 more
core  

Nuclear‐Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance

Advanced Science, EarlyView.
Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu, Jiaqian Feng, Tingting Pan, Pinggen Zhang, Ling Ye, Zetan Jiang, Zilong Zhou, Qiankun Mao, Jian Li, Xinyi Yang, Ping Gao, De Huang, Huafeng Zhang   +12 more
wiley   +1 more source

A Live Cell Imaging‐Compatible Bioreactor for the Interrogation of Cellular Responses to Modulated Flow Conditions

Advanced Science, EarlyView.
An open‐source, low‐cost 3D perfusion system integrating bioprinted scaffolds and live‐imaging overcomes 2D culture limitations. Modeling the cerebrospinal fluid‐filled subarachnoid space, it reveals flow‐dependent focal adhesion kinase activation in meningothelial cells, demonstrating a powerful platform for studying mechanobiology and creating ...
Subashree Srinivasan, Valerie H. Huhle, Claudia C. Bippes, Nina Tanner, Stephan Frank, Hanspeter E. Killer, Corina Kohler, Albert Neutzner   +7 more
wiley   +1 more source