Results 221 to 230 of about 240,985 (333)

Identification of Regions of Rabbit Muscle Pyruvate Kinase Important for Allosteric Regulation by Phenylalanine, Detected by H/D Exchange Mass Spectrometry

, 2013
Charulata B. Prasannan, María T. Villar, Antonio Artigues, Aron W. Fenton   +3 more
openalex   +2 more sources

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Bovine Pyruvate Kinases

Journal of Biological Chemistry, 1973
Janet M. Cardenas, Robert D. Dyson, J. Jeffrey Strandholm   +2 more
openaire   +2 more sources

Pyruvate kinase deficiency links metabolic perturbations to neurodegeneration and axonal protection. [PDF]

Mol Metab
Waller TJ, Collins CA, Dus M.
europepmc   +1 more source

Conformational changes required for pyruvate kinase activity as modulated by monovalent cations.

, 1976
Thomas Nowak
openalex   +1 more source

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

The Functional State of <i>Thermoplasma acidophilum</i> Pyruvate Kinase Relies on an Extra Carboxyl-Terminal Sequence. [PDF]

Int J Mol Sci
Ramírez-Silva L, Riveros-Rosas H, Hernández-Alcántara G, García-Trejo JJ, Vega-Segura A, González-Andrade M, Díaz-Salazar AJ, Salcedo-Barrientos G.   +7 more
europepmc   +1 more source

Pyruvate Kinase Measurement [PDF]

, 2020
openaire   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Malate targets pyruvate kinase M2 to promote colorectal cancer cell cycle arrest and tumor suppression. [PDF]

Mol Biomed
Zhao K, Zhang F, Qin Q, Zhang D, Yang F, Huang Y, Deng R, Jing H, Xiao W, Miao H, Shi R.   +10 more
europepmc   +1 more source