Results 221 to 230 of about 216,078 (374)

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Prognostic Role of Pyruvate Kinase M2 in High-Grade Gliomas: A Quantitative Immunohistochemistry Study. [PDF]

Cureus
Tamas C, Cehan AR, Kövecsi A, Tamas F, Balasa AF.   +4 more
europepmc   +1 more source

Magnetic Resonance and Catalytic Studies of Pyruvate Kinase with Essential Sulfhydryl or Lysyl ε-Amino Groups Chemically Modified

, 1973
Michael Flashner, Ilana Tamir, Albert S. Mildvan, H. Paul Meloche, Minor J. Coon   +4 more
openalex   +1 more source

Isoenzymes of Pyruvate Kinase in Etioplasts and Chloroplasts [PDF]

, 1979
Robert J. Ireland, Vincenzo De Luca, David T. Dennis   +2 more
openalex   +1 more source

Case report: Modified transplantation for pediatric patients with pyruvate kinase deficiency. [PDF]

Front Immunol
Pang Y, Qi X, Qin J, Zhai X, Wang R, Cao J, Zhang N, Liu J, Li J, Wu W, Wei S, Zhang J, Zhang S, Zhang Y, Yue Y.   +14 more
europepmc   +1 more source

Pyruvate kinase activators: targeting red cell metabolism in thalassemia. [PDF]

Hematology Am Soc Hematol Educ Program, 2023
Kuo KHM.
europepmc   +1 more source

Proton Relaxation and Kinetic Studies of Ternary Complexes of an Allosteric Pyruvate Kinase from Yeast

, 1972
G.Larry Cottam, Albert S. Mildvan, James R. Hunsley, Clarence H. Suelter   +3 more
openalex   +1 more source

Evidence for a postsynthetic proteolytic transformation of human erythrocyte pyruvate kinase into L‐type enzyme [PDF]

, 1977
Joëlle Marie, Hervé Garreau, Axel Kahn
openalex   +1 more source

Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase. [PDF]

G3 (Bethesda), 2023
Heidarian Y, Tourigny JP, Fasteen TD, Mahmoudzadeh NH, Hurlburt AJ, Nemkov T, Reisz JA, D'Alessandro A, Tennessen JM.   +8 more
europepmc   +1 more source

Pyruvate Kinase Function Correlates With Red Blood Cell Properties and Clinical Manifestations in Sickle Cell Disease. [PDF]

Am J Hematol
Traets MJM, Bos JF, van der Veen S, van Pelt L, van Dijk MJ, van Oirschot BA, de Wilde JRA, Jans JJ, van Solinge WW, Schols SEM, Lauw MN, Cnossen MH, Nur E, Biemond BJ, Rijneveld AW, van Beers EJ, van Wijk R, Rab MAE.   +17 more
europepmc   +1 more source