Results 261 to 270 of about 216,078 (374)

PSMD14 Transcriptionally Activated by MEF2A Promotes Pancreatic Cancer Development by Upregulating SPON2 Expression

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Proteasome 26S subunit non‐ATPase 14 (PSMD14) plays a pro‐carcinogenic role in various cancers. However, its specific effects and mechanisms in pancreatic cancer (PC) remain unclear. We aimed to assess the function and mechanism of PSMD14 in PC.
Yun‐He Hao, Cheng‐Ru Yang, Wu‐Jiang Shi, Xiang‐Yu Zhong   +3 more
wiley   +1 more source

Pyruvate Kinase M1/2 Proteoformics for Accurate Insights into Energy Metabolism Abnormity to Promote the Overall Management of Ovarian Cancer Towards Predictive, Preventive, and Personalized Medicine Approaches. [PDF]

Metabolites
Wang Y, Xu N, Ndzie Noah ML, Chen L, Zhan X.   +4 more
europepmc   +1 more source

Properties and mechanism of action of creatine kinase from ox smooth muscle. Anion effects compared with pyruvate kinase [PDF]

, 1973
B. Focant, David C. Watts
openalex   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Optimized Dynamic Network Biomarker Deciphers a High‐Resolution Heterogeneity Within Thyroid Cancer Molecular Subtypes

Med Research, EarlyView.
An optimized dynamic network biomarker approach reveals a critical transition signal and identifies three distinct molecular subtypes of differentiated thyroid cancer, each with unique global regulatory landscapes. ABSTRACT The progression of differentiated thyroid carcinoma (DTC) poses significant clinical challenges, especially in determining the ...
Haonan Zhang, Ge Zhang, Pengyuan Xu, Fengyi Yu, Liwen Li, Runzhi Huang, Pengpeng Zhang, Kaisaierjiang Kadier, Yuanyuan Wang, Qiqi Gu, Yalei Ding, Tianshu Gu, Hao Chi, Shiqian Zhang, Ruhao Wu, Yudi Xu, Shanshan Zhu, Honglin Zheng, Taiqi Zhao, Qi He, Xinguang Qiu   +20 more
wiley   +1 more source

Sodium danshensu modulates skeletal muscle fiber type formation and metabolism by inhibiting pyruvate kinase M1. [PDF]

Front Pharmacol
Zhang Y, Wu X, Li R, Sui M, Li G, Fan S, Yang M, Liu Q, Liu X, Wu C, Li L.   +10 more
europepmc   +1 more source

Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform

Movement Disorders, EarlyView.
Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles, Dilan Athauda, Thomas R. Barber, Roger A. Barker, David T. Dexter, Susan Duty, Romy Ellis‐Doyle, Sonia Gandhi, Joel Handley, Edwin Jabbari, Keith Martin, Kevin McFarthing, Georgia Mills, Heather Mortiboys, Stephen Mullin, Rebecca Petty, Esther Sammler, Paula Scurfield, Simon R.W. Stott, George K. Tofaris, Li Wei, Caroline H. Williams‐Gray, Alan Wong, Marie‐Louise Zeissler, Richard K. Wyse, Camille B. Carroll, Thomas Foltynie, Oliver Bandmann, Anthony H.V. Schapira, on behalf of the EJS ACT‐PD Consortium   +29 more
wiley   +1 more source

Activating pyruvate kinase improves red blood cell integrity by reducing band 3 tyrosine phosphorylation. [PDF]

Blood Adv
Le K, Wang X, Chu J, Lundt M, Lee YY, Conrey A, Frey I, Giannini S, Kosinski PA, Hausman JM, Low PS, Jeffries N, Desai SA, Thein SL.   +13 more
europepmc   +1 more source

The reversibility of skeletal muscle pyruvate kinase and an assessment of its capacity to support glyconeogenesis.

, 1975
RD Dyson, JM Cardenas, RJ Barsotti
openalex   +1 more source

Effects of Quercetin Metabolites on Glucose‐Dependent Lipid Accumulation in 3T3‐L1 Adipocytes

Molecular Nutrition &Food Research, EarlyView.
Quercetin metabolites (QMs), found in foods like fruits and vegetables, can influence how fat cells process fats and sugars. This study shows that QMs help reduce fat storage and sugar uptake in fat cells when sugar levels are high. Under conditions mimicking caloric restriction, they boost sugar use for energy.
Marco Rendine, Samuele Venturi, Mirko Marino, Claudio Gardana, Peter Møller, Daniela Martini, Patrizia Riso, Cristian Del Bo   +7 more
wiley   +1 more source