Results 311 to 320 of about 216,078 (374)

Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging

Aging Cell, EarlyView.
The molecular underpinnings of divergent cognitive trajectories in aging remain unresolved. Using high‐resolution behavioral testing to cognitively stratify aged male mice into ‘intact’ and ‘impaired’ subgroups, we show that reactive gliosis and cellular senescence are key determinants of disparities in cognitive function with age.
Matthew P. Baier, Rojina Ranjit, Daniel B. Owen, Jenna L. Wilson, Megan A. Stiles, Anthony M. Masingale, Zachary Thomas, Anne Bredegaard, David M. Sherry, Sreemathi Logan   +9 more
wiley   +1 more source

Mitapivat improves ineffective erythropoiesis and iron overload in adult patients with pyruvate kinase deficiency. [PDF]

Blood Adv
van Beers EJ, Al-Samkari H, Grace RF, Barcellini W, Glenthøj A, DiBacco M, Wind-Rotolo M, Xu R, Beynon V, Patel P, Porter JB, Kuo KHM.   +11 more
europepmc   +1 more source

Metabolic blood profile and response to treatment with the pyruvate kinase activator mitapivat in patients with sickle cell disease. [PDF]

Hemasphere
van Dijk MJ, Ruiter TJJ, van der Veen S, Rab MAE, van Oirschot BA, Bos J, Derichs C, Rijneveld AW, Cnossen MH, Nur E, Biemond BJ, Bartels M, Schutgens REG, van Solinge WW, Jans JJM, van Beers EJ, van Wijk R.   +16 more
europepmc   +1 more source

The role of NAD-dependent deacetylase sirtuin-2 in liver metabolic stress through regulating pyruvate kinase M2 ubiquitination. [PDF]

J Transl Med
Guo J, Nie J, Li D, Zhang H, Zhao T, Zhang S, Ma L, Lu J, Ji H, Li S, Tao S, Xu B.   +11 more
europepmc   +1 more source

Pyruvate kinase deficiency and PKLR gene mutations: Insights from molecular dynamics simulation analysis. [PDF]

Heliyon
Wang Y, Liu J, Liu T, An X, Huang L, Li J, Zhang Y, Xiang Y, Xiao L, Yi W, Qin J, Liu L, Wang C, Yu J.   +13 more
europepmc   +1 more source

Corrigendum: Sulforaphane diminishes moonlighting of pyruvate kinase M2 and interleukin 1β expression in M1 (LPS) macrophages. [PDF]

Front Immunol
Bahiraii S, Brenner M, Yan F, Weckwerth W, Heiss EH.   +4 more
europepmc   +1 more source

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Mutations in pyruvate kinase

Human Mutation, 1996
Pyruvate kinase (PK) deficiency due to mutations of the PKLR gene is a common cause of hereditary nonspherocytic hemolytic anemia. Thus far, 55 different mutations have been described in patients with PK-deficient hemolytic anemia. Polymorphisms within the PKLR gene and in the tightly linked glucocerebrosidase (GBA) gene suggest that PK deficiency may ...
Ernest Beutler, Luciano Baronciani
openaire   +3 more sources

Pyruvate kinase deficiency

Clinical Biochemistry, 1990
Pyruvate kinase (PK) deficiency was initially described by Valentine et al. in 1961. Since then, more than 300 cases have been described, including 65 in Japan. PK deficiency is the most common hereditary nonspherocytic hemolytic anemia among several red cell enzyme defects of the Embden-Meyerhof glycolytic pathway.
Hisaichi Fujii, Shiro Miwa
openaire   +3 more sources