Results 151 to 160 of about 51,864 (248)

Role of Th1/Th2 imbalance mediated by T cell glycolytic rate-limiting enzymes hexokinase 2, phosphofructokinase-1, and pyruvate kinase M2 in oral lichen planus

Romanian Journal of Laboratory Medicine
We aimed to explore the role of T helper cell 1 (Th1)/Th2 imbalance mediated by T cell glycolytic rate-limiting enzymes hexokinase 2 (HK2), phosphofructokinase-1 (PEK1) and pyruvate kinase M2 (PKM2) in oral lichen planus (OLP).
Yao Min, Li Lijuan, Xiao Lingling, Zhuang Yunxia, Sun Guangrong   +4 more
doaj   +1 more source

Oleuropein‐based olive leaf extract enhances muscle mitochondrial bioenergetics response to moderate – but not maximal – intensity exercise in humans

The Journal of Physiology, EarlyView.
Abstract figure legend In a double‐blind, crossover study, we observed that olive leaf extract (OLE) intake combined with a single session of moderate‐intensity continuous exercise (MICE) significantly enhanced skeletal muscle mitochondrial bioenergetics, whereas this effect was milder when OLE was combined with sprint interval exercise (SIE ...
Clément Lanfranchi, Alba Moreno‐Asso, Astrid M. H. Horstman, Sara Mistro, Eugenia Migliavacca, Ornella Cominetti, Jens Stolte, Sylviane Métairon, Aurélie Hermant, Ane Laura Pedersen, Loïc Dayon, Umberto De Marchi, Jérôme N. Feige, Nadège Zanou, Nicolas Place   +14 more
wiley   +1 more source

Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia

Haematologica, 2009
Esther Hulleman, Mathilde JC Broekhuis, Rob Pieters, Monique L Den Boer   +3 more
doaj   +1 more source

RAGE Re‐Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Cancer cachexia (CC) is a highly debilitating syndrome characterized by loss of body and muscle weight affecting most advanced cancer patients. The receptor for advanced glycation end‐products (RAGE) is expressed by several cell types and sustains the inflammatory response in acute and chronic diseases. Total ablation of RAGE (Ager−/
Sara Chiappalupi, Giulia Gentili, Laura Salvadori, Martina Paiella, Marcello Manfredi, Vittoria Federica Borrini, Kaamashri Mangar, Ann Marie Schmidt, Maurizio Muscaritoli, Francesca Riuzzi, Guglielmo Sorci   +10 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Pyruvate kinase M2 isozyme (PKM2) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

Postexercise Lactate Clearance, T2 Relaxation, and J‐Modulation in Human Skeletal Muscle Measured With Double‐Quantum Filtered 1H MRS at 7 T

Magnetic Resonance in Medicine, Volume 95, Issue 6, Page 3065-3076, June 2026.
ABSTRACT Purpose 1H MRS lactate measurements are potentially valuable for studying energy metabolism in working skeletal muscle, but some technical obstacles need to be overcome. Spectral filtering to isolate the lactate signal from overlapping lipid resonances shows promise.
Kostiantyn Repnin, Vasco Rafael Rocha dos Santos, Veronika Cap, Roberta Frass‐Kriegl, Siegfried Trattnig, Graham J. Kemp, Martin Meyerspeer   +6 more
wiley   +1 more source

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi, Nian Liu, Jingyi Gu, Yinling Wang, Weiye Wang, Zhiwei Ke, Mingjun Xie, Wenjing Jin, Weicheng Kong, Jue Shi, Hui Pan, Yong He, Zhijian Xie   +12 more
wiley   +1 more source

Pyruvate Kinase Isozyme M2 Measurement [PDF]

, 2020
openaire   +1 more source

Regulation of human M2 pyruvate kinase

, 2015
Pyruvate kinase catalyses the final step in glycolysis and is responsible for net ATP production. There are four pyruvate kinase isoforms expressed in humans; LPYK, RPYK, M1PYK and M2PYK. The allosteric enzyme M2PYK plays an important role in cancer cell metabolism and is subject to complex regulation by numerous naturally occurring small-molecule ...
openaire   +1 more source