Results 171 to 180 of about 51,864 (248)

Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal‐Associated Invariant T (MAIT) Cell Function

Immunology, Volume 178, Issue 1, Page 97-108, May 2026.
Integrated transcriptomic, proteomic and flow cytometry analyses reveal that STAT1 negatively regulates MAIT cell effector and glycolytic functions, while STAT3, STAT5 and HIF1α act as positive modulators. Targeting these pathways may offer new strategies to restore MAIT cell function in immune dysregulation and cancer.
Olivia J. Cheng, Eimear K. Ryan, Michael Bennett, Christy Clutter, Jackson G. Cacioppo, Jeffrey Aubé, Andy E. Hogan, Daniel T. Leung   +7 more
wiley   +1 more source

Pyruvate kinase M2 in Alzheimer's disease: from dysregulation to therapeutic inhibition. [PDF]

Brain Commun
Gojani EG, Sutherland RJ, Mohajerani MH.
europepmc   +1 more source

Diagnostic and Prognostic Values of Bile Biomarkers for Malignant Biliary Stenosis

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Introduction Differentiating between malignant and benign biliary strictures remains a clinical challenge because current diagnostic tools have limited sensitivity. The detection of tumour‐related biomarkers directly in bile, which is in close contact with the lesion, may enhance diagnostic accuracy.
E. Gigante, V. Untereiner, S. Caruso, R. Rhaiem, L. Grados, C. Boulagnon‐Rombi, S. Adam, G. D. Sockalingum, R. Garnotel, G. Thiefin   +9 more
wiley   +1 more source

Quantitative Phosphoproteomics Identifies Myofibrillar Protein Phosphorylation Mediated by Pyruvate Kinase M2 in Beef. [PDF]

Foods
Xu Y, Liu X, Ren C, Hou C, Li X, Zhang D.   +5 more
europepmc   +1 more source

Cell‐Type‐Dependent Metabolic Compensation Preserves Photoreceptor Survival Through Pyruvate Kinase Isoform Balance

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
We investigated the roles of PKM2, PKM1, and LDHA in retinal metabolism and structural integrity. In the normal retina, these enzymes are maintained at defined levels that support photoreceptor function. Rod‐specific deletion of LDHA, alone or with PKM2, caused age‐dependent degeneration, as PKM1 induction did not reach levels comparable to PKM2.
Ammaji Rajala, Larissa J. Trevino, Tyler M. Black, Raju V. S. Rajala   +3 more
wiley   +1 more source

Changes of Serum Pyruvate Kinase M2 Level in Patients with Sepsis and Its Clinical Value. [PDF]

Infect Drug Resist, 2023
Wang L, Tang D, Zhang P.
europepmc   +1 more source

Pyruvate kinase M2 promotes venous thrombosis by enhancing SNAP23-mediated platelet exocytosis and consequent NETosis. [PDF]

Blood Adv
Nayak MK, Flora GD, Budnik I, Barbhuyan T, Patel RB, Ghatge M, Kumskova M, Jain A, Chauhan N, Kumar J, Jewell M, Kumar S, Lentz SR, Neeves KB, Chauhan AK.   +14 more
europepmc   +1 more source

Pyruvate kinase M2 modulates Japanese encephalitis virus replication in neuronal cells. [PDF]

J Gen Virol
Bohara VS, Deshmukh A, Kumar S.
europepmc   +1 more source

Pyruvate Kinase M2 Links Metabolism and Epigenetics: A New Target for Liver Disease Treatment. [PDF]

Biomolecules
Zhang X, Zhang D, Guo J, Shi C, Gong Z.
europepmc   +1 more source

Pyruvate Kinase PKM Isoform M2 Dimer [PDF]

, 2020
openaire   +1 more source