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Optical Quantal Analysis [PDF]

Frontiers in Synaptic Neuroscience, 2019
Understanding the mechanisms by which long-term synaptic plasticity is expressed remains an important objective in neuroscience. From a physiological perspective, the strength of a synapse can be considered a consequence of several parameters including ...
Matthew J. MacDougall, Alan Fine
doaj   +5 more sources

A Novel Optical Quantal Analysis of Miniature Events Reveals Enhanced Frequency Following Amyloid β Exposure [PDF]

Frontiers in Cellular Neuroscience, 2020
Non-evoked miniature release of neurotransmitters is increasingly recognized as playing an important role in neural function and is implicated in synaptic plasticity, metaplasticity, and homeostasis.
Henry B. C. Taylor, Rudi Tong, Rudi Tong, Alexander F. Jeans, Nigel J. Emptage   +4 more
doaj   +2 more sources

Optical Quantal Analysis Using Ca2+ Indicators: A Robust Method for Assessing Transmitter Release Probability at Excitatory Synapses by Imaging Single Glutamate Release Events [PDF]

Frontiers in Synaptic Neuroscience, 2019
Despite evidence that presynaptic efficacy and plasticity influence circuit function and behavior in vivo, studies of presynaptic function remain challenging owing to the difficulty of assessing transmitter release in intact tissue.
Zahid Padamsey, Rudi Tong, Nigel Emptage
doaj   +2 more sources

Parsing Out the Variability of Transmission at Central Synapses Using Optical Quantal Analysis [PDF]

Frontiers in Synaptic Neuroscience, 2019
Properties of synaptic release dictates the core of information transfer in neural circuits. Despite decades of technical and theoretical advances, distinguishing bona fide information content from the multiple sources of synaptic variability remains a ...
Cary Soares, Daniel Trotter, André Longtin, André Longtin, Jean-Claude Béïque, Richard Naud, Richard Naud   +6 more
doaj   +2 more sources

Progressive overfilling of readily releasable pool underlies short-term facilitation at recurrent excitatory synapses in layer 2/3 of the rat prefrontal cortex [PDF]

eLife
Short-term facilitation of recurrent excitatory synapses within the cortical network has been proposed to support persistent activity during working memory tasks, yet the underlying mechanisms remain poorly understood.
Jiwoo Shin, Seung Yeon Lee, Yujin Kim, Suk-Ho Lee   +3 more
doaj   +2 more sources

The invasion pore induced by Toxoplasma gondii [PDF]

EMBO Reports
The parasite Toxoplasma gondii invades its host cell only after secreting proteins such as invasion-requisite RON2 that inserts into the host cell membrane to establish the moving junction.
Yuto Kegawa, Frances Male, Irene Jiménez-Munguía, Paul S Blank, Elena Mekhedov, Gary E Ward, Joshua Zimmerberg   +6 more
doaj   +2 more sources

Average miniature post-synaptic potential size is inversely proportional to membrane capacitance across neocortical pyramidal neurons of different sizes [PDF]

Frontiers in Cellular Neuroscience
In chemical synapses of the central nervous system (CNS), information is transmitted via the presynaptic release of a vesicle (or ‘quantum’) of neurotransmitter, which elicits a postsynaptic electrical response with an amplitude termed the ‘quantal size.’
Martynas Dervinis, Guy Major
doaj   +2 more sources

Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach. [PDF]

PLoS Computational Biology
Quantal parameters of synapses are fundamental for the temporal dynamics of neurotransmitter release, which is the basis of interneuronal communication.
Zahra Vahdat, Oliver Gambrell, Jonas Fisch, Eckhard Friauf, Abhyudai Singh   +4 more
doaj   +2 more sources

Resolving synaptic events using subsynaptically targeted GCaMP8 variants [PDF]

eLife
While genetically encoded Ca2+ indicators are valuable for visualizing neural activity, their speed and sensitivity have had limited performance when compared to chemical dyes and electrophysiology, particularly at synaptic compartments.
Jiawen Chen, Junhao Lin, Kaikai He, Luyi Wang, Yifu Han, Chengjie Qiu, Jasmine M Wheeler, Catherine M Daly, Gregory T Macleod, Dion K Dickman   +9 more
doaj   +2 more sources

Estimates of quantal synaptic parameters in light of more complex vesicle pool models [PDF]

Frontiers in Cellular Neuroscience
The subdivision of synaptic vesicles (SVs) into discrete pools is a central concept of synaptic physiology. To better explain specific properties of transmission and plasticity, it was initially suggested that the readily releasable pool (RRP) of SVs is ...
Simone Brachtendorf, Grit Bornschein, Hartmut Schmidt   +2 more
doaj   +2 more sources