Results 221 to 230 of about 327,904 (307)

Validation of an UHPLC-MS/MS Assay for the Quantification of Isoniazid and Four Major Metabolites in Human Plasma. [PDF]

Biomed Chromatogr
Nerguizian D, Klein B, Abdelmawla F, Gomez J, Anderson PL, Bushman L, Brooks KM.   +6 more
europepmc   +1 more source

Host resistance modulates in planta efficacy of seed‐applied fluxapyroxad against spot form net blotch in barley

Pest Management Science, EarlyView.
Barley variety influences fluxapyroxad efficacy by affecting distribution and dissipation of the active ingredient, with plant biomass contributing to these differences. Abstract BACKGROUND Seed‐applied fungicides are used to protect barley seedlings from spot form net blotch, caused by Pyrenophora teres f. maculata, among other diseases.
Varthini Govindaraju Punithan, Adam H Sparks, Mark Gibberd, Jordan Campbell, Arundhati Singh, M Jordi Muria‐Gonzalez   +5 more
wiley   +1 more source

Starvation-induced HSC70 O-GlcNAcylation activates chaperone-mediated autophagy. [PDF]

J Biol Chem
Xu N, Wang X, Zhang J, Zhao J, Yan S, Zhou W, Chi W, Li J.   +7 more
europepmc   +1 more source

Analysis of C4 Concentrations to Predict Impact of Patient‐Reported Diarrhea Associated With the Ileal Bile Acid Transporter Inhibitor Linerixibat

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.
ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño, Rashmi Mehta, Andrea Ribeiro de Souza, Jon Collins, Brandon Swift   +4 more
wiley   +1 more source

Quantification of Human Cardiac Ion Channels by Parallel Reaction Monitoring and In-Sample Calibration. [PDF]

ACS Omega
Torkamannejad S, Yip HY, Sun B.
europepmc   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

Ubiquitin ligase RCHY1 regulates autophagosome-lysosome fusion. [PDF]

Cell Death Discov
Umargamwala R, Manning J, Carosi JM, Denton D, Kumar S.   +4 more
europepmc   +1 more source

Reverse‐Engineered Lipid Nanoparticles Harness Protein Corona Formation for Cytokine Sequestration and Combination Immunomodulatory Therapy

Small, EarlyView.
Bioinspired triglyceride‐ceramide lipid nanoparticles were reverse‐engineered from cytokine‐sequestering plant‐derived nanoparticles to capture pathological inflammatory mediators through protein corona formation. Dexamethasone‐loaded TCNPs combine extracellular cytokine sequestration with intracellular immunomodulation, reducing IL‐6, TNF‐α, and NF‐κΒ
Junsik J. Sung, Gargi Yogesh Digholkar, Ryan M. Pearson   +2 more
wiley   +1 more source

Convenient Determination of Trace Methylcyclosiloxanes in Water by Vortex-Assisted Small-Scale Liquid-Liquid Extraction and GC-MS Analysis. [PDF]

Rapid Commun Mass Spectrom
Fang J, Yuan Z, Zhao Y, Teng L, An L, Jiang K.   +5 more
europepmc   +1 more source

Innovative 3D‐bioprinted microfibers in calcium phosphate cement platform with Nell‐1 to activate nerve‐bone axis for synergistic bone, vasculature, and nanofibrous nerve regeneration

Smart Molecules, EarlyView.
A 3D‐bioprinted platform with stem cells activates “nerve‐bone” signaling by enabling the spatiotemporal delivery of Nell‐1. This activation enhances neurovascular and bone regeneration through the CYFIP1 cascade. In rat calvarial defects, the platform doubled bone regeneration and nerve repair and tripled vascular density, resulting in superior ...
Minjia Zhu, Xinyi Li, Jingyi Li, Kan Yu, Zixiang Dai, Le Xiao, Qinrou Zhang, Zihan Jia, Qingchen Qiao, Zeqing Zhao, Ke Zhang, Yuxing Bai   +11 more
wiley   +1 more source