Results 231 to 240 of about 498,441 (308)

First 20 Years of Orbitrap Mass Spectrometry as the Mainstream Analytical Technique

Mass Spectrometry Reviews, EarlyView.
ABSTRACT This review traces the first 20 years of Orbitrap mass spectrometry as a mainstream high‑resolution and accurate‑mass (HR/AM) technology. It outlines the historical development of the Orbitrap analyzer, the evolution of major instrument families, and the key technological innovations that enabled its widespread adoption. Particular emphasis is
Alexander Makarov
wiley   +1 more source

Correction: Akt3 links mitochondrial function to the regulation of Aurora B and mitotic fidelity. [PDF]

PLoS One
PLOS One Staff.
europepmc   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source

The m6Am methyltransferase PCIF1 promotes osteogenic differentiation of mesenchymal stem cells through stabilization of Wnt-related transcripts. [PDF]

PLoS Biol
Song W, Su KJ, Pan Z, Zhang Z, Yin Q, Lin W, Liu L, Gong Y, Liang B, Cai Y, Li Q, Shen H, Deng HW, Yuan Q.   +13 more
europepmc   +1 more source

Restoration of Immune Surveillance in Prostate Cancer Prevention by Sulforaphane in Hi‐Myc Mice

Molecular Carcinogenesis, EarlyView.
ABSTRACT Oral administration of broccoli constituent sulforaphane (SFN) prevents prostate cancer development in preclinical mouse models. However, the mechanism(s) underlying prostate cancer prevention by SFN are not fully understood. In this study, we used a human relevant mouse model (Hi‐Myc mice) to demonstrate restoration of immune surveillance by ...
Krishna B. Singh, Eun‐Ryeong Hahm, Joshi J. Alumkal, Shivendra V. Singh   +3 more
wiley   +1 more source

Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex. [PDF]

Nat Commun
Lin LL, Maldosevic E, Zhou LE, Jomaa A, Qi L.   +4 more
europepmc   +1 more source

Biomarkers of Leucine‐Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy

Movement Disorders, EarlyView.
Abstract Background Common and rare genetic variants in leucine‐rich repeat kinase 2 (LRRK2) have been linked with sporadic and familial Parkinson's disease (PD). Recently, we discovered that common genetic variation near the LRRK2 locus determined survival in progressive supranuclear palsy (PSP).
Louise‐Kristine Nielsen, Joshua L.I. Frost, David P. Vaughan, Raquel Real, Riona Fumi, Marte Theilmann Jensen, Megan Hodgson, Eleanor J. Stafford, Lesley Wu, Olaf Ansorge, Annelies Quaegebeur, Kieren S.J. Allinson, Thomas T. Warner, Zane Jaunmuktane, Anjum Misbahuddin, P. Nigel Leigh, Boyd C.P. Ghosh, Kailash P. Bhatia, Alistair Church, Christopher Kobylecki, Michele T.M. Hu, James B. Rowe, Alan A. Shomo, Danielle L. Graham, Omar S. Mabrouk, Huw R. Morris, Esther M. Sammler, Edwin Jabbari   +27 more
wiley   +1 more source

A Rapid Fluorescence Method for In Vivo Quantitation of Lung Deposition of a Nebulized Drug: Multiple Uses for Advancing Aerosolized Drug Development and Specific Insight Regarding Aerosolized Vitamin A for Preventing Bronchopulmonary Dysplasia. [PDF]

Methods Protoc
Gelfand CA, Wang Y, Chandan G, Liu J, Madrigal S, Sakurai R, Yu C, Guerra C, Segal R, Rehan VK.   +9 more
europepmc   +1 more source

MRI for Mixing Quality in Microfluidics

Magnetic Resonance in Chemistry, EarlyView.
Fluidic mixing in a micromixer: Paramagnetic relaxation enhancement and chemical shift differences were explored to reveal mixing quality at the small dimensions of an optically opaque y‐mixer. ABSTRACT Liquid state processes often involve mixing of process streams.
J. Götz, T. Rudszuck, L. Kontschak, T. Oerther, H. Nirschl, G. Guthausen   +5 more
wiley   +1 more source

Comparative assessment of endogenous lipid transfer protein (LTP) level in genetically modified maize for its relevance in safety assessment. [PDF]

GM Crops Food
Ma E, Joshi S, Birukou I, Rosenbaum E.
europepmc   +1 more source