Results 71 to 80 of about 6,348,682 (283)

Epidemiology of Acute Cardiovascular and Cerebrovascular Events in the Lombardy Region: A Population-Based Study (2015–2021)

Epidemiology, Biostatistics and Public Health
Introduction Cardiovascular and cerebrovascular diseases represent one of the leading causes of morbidity and mortality in Italy [1]. Acute events such as myocardial infarction and ischemic stroke have a significant clinical, economic, and social ...
Ginevra Torrigiani , Marta Baviera , Antonella Zambon   +2 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Handwriting analysis for diagnosis and prognosis of Parkinson’s disease [PDF]

, 2010
At present, there are no quantitative, objective methods for diagnosing the Parkinson disease. Existing methods of quantitative analysis by myograms suffer by inaccuracy and patient strain; electronic tablet analysis is limited to the visible drawing ...
Brause, Rüdiger W., Krakow, Karsten, Ünlü, Atilla   +2 more
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Combining healthiness and sustainability: An analysis of consumers’ preferences and willingness to pay for functional and sustainable snack bars

Future Foods
Despite the growing attention paid by consumers and policy makers to health and sustainability issues, contribution analyzing consumers attitude towards both health related and sustainability attributes of foods are lacking.
Anna Uliano, Marcello Stanco, Giuseppe Marotta, Concetta Nazzaro   +3 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

QuantUM: Quantitative Safety Analysis of UML Models

, 2011
When developing a safety-critical system it is essential to obtain an assessment of different design alternatives. In particular, an early safety assessment of the architectural design of a system is desirable.
A. Aziz, A. Hinton, Adnan Aziz, Christel Baier, D. Latella, David Nicolaas Jansen, E. M. Clarke, Florian Leitner-Fischer, Florian Leitner-Fischer, Gethin Norman, H. Aljazzar, H. Boudali, Husain Aljazzar, Husain Aljazzar, I. Majzik, J.Y. Halpern, Lars Grunske, Lars Grunske, Leslie Lamport, M. Ajmone Marsan, Mieke Massink, S. Bernardi, Stefan Leue, V.G. Kulkarni   +23 more
core   +2 more sources

The Dynamic Window Approach as a Tool to Improve Performance of Nonparametric Self-Starting Control Charts

Mathematics
The change-point model is an established methodology for the construction of self-starting control charts. Change-point charts are often nonparametric in order to be independent from any specific assumptions about the process distribution.
Claudio Giovanni Borroni, Manuela Cazzaro, Paola Maddalena Chiodini   +2 more
doaj   +1 more source

Joinpoint regression analysis with time-on-study as time-scale. Application to three Italian population-based cohort studies

Epidemiology, Biostatistics and Public Health, 2017
Background: Joinpoint regression analysis is usually applied to study varying trends over time in order to identify the time point(s) in which the trend significantly changes.
Eleonora Pagan, Federico Rea, Matteo Monzio Compagnoni, Anna Cantarutti, Pietro Pugni, Vincenzo Bagnardi, Giovanni Corrao   +6 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source