Results 91 to 100 of about 20,185 (216)

When Do Trait-Based Higher Order Interactions and Individual Variation Promote Robust Species Coexistence? [PDF]

Ecol Evol
Baruah G, Barabás G, John R.
europepmc   +1 more source

Genomic technologies and the diagnosis of 46, XY differences of sex development

Andrology, EarlyView.
Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris, Andrew H. Sinclair, Katie L. Ayers   +2 more
wiley   +1 more source

Joining forces to push past paradoxes: Combining quantitative genetics and genomics shows evolution hiding in plain sight. [PDF]

Proc Natl Acad Sci U S A
Bonnet T.
europepmc   +1 more source

How exome sequencing improves the diagnostics and management of men with non‐syndromic infertility

Andrology, EarlyView.
Abstract Male infertility affects approximately 17% of all men and represents a complex disorder in which not only semen parameters such as sperm motility, morphology, and number of sperm are highly variable, but also testicular phenotypes range from normal spermatogenesis to complete absence of germ cells.
Birgit Stallmeyer, Ann‐Kristin Dicke, Frank Tüttelmann   +2 more
wiley   +1 more source

Pitfalls in performing genome-wide association studies on ratio traits. [PDF]

HGG Adv
McCaw ZR, Dey R, Somineni H, Amar D, Mukherjee S, Sandor K, insitro Research Team, Karaletsos T, Koller D, Aschard H, Smith GD, MacArthur D, O'Dushlaine C, Soare TW.   +13 more
europepmc   +1 more source

Cryptorchidism: Novel genetic insights into CCDC149 mutations

Andrology, EarlyView.
Abstract Background Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149, a coiled‐coil domain‐containing protein, has been implicated in various developmental processes, but its role in the male ...
Shengrong Du, Shan Xu, Lei Yang, Yan Ye, Yuhan Wu, Ziyun Xiao, Xiuqing Dong, Wenliang Yao, Hua Li   +8 more
wiley   +1 more source

Quantitative omnigenic model discovers interpretable genome-wide associations. [PDF]

Proc Natl Acad Sci U S A
Ružičková N, Hledík M, Tkačik G.
europepmc   +1 more source

How data or error covariance can change and still retain BLUEs as well as their covariance or the sum of squares of errors

Australian &New Zealand Journal of Statistics, EarlyView.
Summary Misspecification of the error covariance in linear models usually leads to incorrect inference and conclusions. We consider two linear models, A$$ \mathcal{A} $$ and B$$ \mathcal{B} $$, with the same design matrix but different error covariance matrices. The conditions under which every representation of the best linear unbiased estimator (BLUE)
Stephen J. Haslett, Jarkko Isotalo, Augustyn Markiewicz, Simo Puntanen   +3 more
wiley   +1 more source

Genome-wide analysis of genetic loci and candidate genes related to teat number traits in Dongliao black pigs. [PDF]

Front Genet
Ke J, Chen C, Fei J, Luo K, Cheng Y, Yu H, Cheng C, Yan Y, Zhang X, Liang S, Sun H, Bai C, Sun B.   +12 more
europepmc   +1 more source

The DCIDE framework: systematic investigation of evolutionary hypotheses, exemplified with autism

Biological Reviews, EarlyView.
ABSTRACT Evolutionary explanations of mental disorders are a longstanding aim of evolutionary psychiatry, but have suffered from complexities including within‐disorder heterogeneity and environmental effects of contemporary societies obscuring possible ancestral functions.
Adam D. Hunt, Adrian V. Jaeggi
wiley   +1 more source