Results 31 to 40 of about 20,185 (216)

Using Extended Genealogy to Estimate Components of Heritability for 23 Quantitative and Dichotomous Traits

PLoS Genetics, 2013
Important knowledge about the determinants of complex human phenotypes can be obtained from the estimation of heritability, the fraction of phenotypic variation in a population that is determined by genetic factors. Here, we make use of extensive phenotype data in Iceland, long-range phased genotypes, and a population-wide genealogical database to ...
Peter Kraft, Peter Kraft, Noah Zaitlen, Bogdan Pasaniuc, Gaurav Bhatia, Gaurav Bhatia, Nick Patterson, Samuela Pollack, Samuela Pollack, Alkes L. Price, Alkes L. Price   +10 more
openaire   +7 more sources

Functionalized Biomimetic Nanoparticles Targeting the IL‐10/IL‐10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis

Advanced Science, EarlyView.
The MOF material UIO‐66‐NH2 is functionalized with DBCO groups on its surface, encapsulating NO‐prednisolone and conjugating it with azide‐modified IL‐10. Finally, the complex is extruded with MM to form biomimetic functional nanoparticles. Upon intra‐articular injection, MI@UN, enveloped by the MM, specifically targets synovial macrophages, is ...
Wenwei Li, Yang Liu, Ming Wei, Zhichao Yang, Zhaoyu Li, Zezhong Guo, Liang Yan, Yang Lu, Hao Tang, Bofeng Li, Wei Huang   +10 more
wiley   +1 more source

Heritable variation and genetic correlation of quantitative traits within and between ecotypes ofAvena barbata [PDF]

Journal of Evolutionary Biology, 2008
AbstractWe examined heritable variation for quantitative traits within and between naturally occurring mesic and xeric ecotypes of the slender wild oat (Avena barbata), and in 188 recombinant inbred lines derived from a cross between the ecotypes. We measured a suite of seedling and adult traits in the greenhouse, as well as performance‐related traits ...
Robert G. Latta, Kyle M. Gardner
openaire   +3 more sources

Exploring barriers to utilizing local agricultural products in the catering industry

Agribusiness, EarlyView.
Abstract Both the proportion and expenditure of dining out and takeaway in Taiwan have been increasing year by year. This study investigates the factors influencing the catering service providers (CSPs) procurement of domestically produced or imported food materials.
Wan‐Yu Liu, Hsing‐Wei Lin, Chun‐Cheng Lin   +2 more
wiley   +1 more source

Highly Stable Aggregation‐Induced Emission‐Functionalized Histatin1 Coated With Platelet Vesicles for Diabetic Wound Healing

Aggregate, EarlyView.
Diabetic wound healing is blocked by persistent inflammation and oxidative stress. Bioactive substances like growth factors and Hsts promote repair but lack long‐term stability. Herein, a platelet membrane‐coated nanoparticle system (PNP) is proposed to achieve enhanced retention of aggregation‐induced emissive (AIE) molecular‐modified Hst1 (Hst1‐AIE ...
Xiaoxuan Lei, Judun Zheng, Xu Chen, Liwen Liang, Zhuohong Li, Cancan Huang, Minghai Zhao, Gang Wu, Yuhui Liao, Bin Yang   +9 more
wiley   +1 more source

Perspectives on the Current and Future State of Artificial Intelligence in Medical Genetics

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Artificial intelligence (AI) is rapidly transforming numerous aspects of daily life, including clinical practice and biomedical research. In light of this rapid transformation, and in the context of medical genetics, we assembled a group of leaders in the field to respond to the question about how AI is affecting, and especially how AI will ...
Benjamin D. Solomon, Morgan Cheatham, Thales A. C. de Guimarães, Dat Duong, Melissa A. Haendel, Tzung‐Chien Hsieh, Behnam Javanmardi, Britt Johnson, Peter Krawitz, Paul Kruszka, Tim Laurent, Ni‐Chung Lee, Kirsty McWalter, Michel Michaelides, Klaus Mohnike, Nikolas Pontikos, Maria J. Guillen Sacoto, Yousif J. Shwetar, Vincent D. Ustach, Rebekah L. Waikel, William Woof   +20 more
wiley   +1 more source

Quantitative Trait Loci: Heritability, Linkage and Association

, 2017
Talk given during the "Introduction to Imaging Genetics" workshop at the 2012 Organization for Human Brain Mapping (OHBM) conference in in Beijing, 10-14 June.
openaire   +1 more source

A Transcriptome‐Wide Mendelian Randomization Study in Isolated Human Immune Cells Highlights Risk Genes Involved in Viral Infections and Potential Drug Repurposing Opportunities for Schizophrenia

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey, Liam Gaziano, Preethi Eldi, Catherine Toben, Beben Benyamin, S. Hong Lee, Elina Hyppönen   +6 more
wiley   +1 more source

Quantitative Traits: Heritability, Linkage & Association

, 2017
Talk given as part of the "Introduction to Imaging Genetics" workshop during the 2010 Organization for Human Brain Mapping (OHBM) conference in Barcelona.
openaire   +1 more source

Mathematical derivations from Niche construction in quantitative traits: heritability and response to selection

, 2022
A. (N − 1)-individual indirect genetic effect, B. Phenotypic variance, C. Heritability, D. Family resemblances, E.
Fogarty, Laurel, Wade, Michael J.
openaire   +1 more source