Results 21 to 30 of about 8,280 (111)
APMIS, Volume 133, Issue 12, December 2025.ABSTRACT RNA hairpins may constitute a foundation of genetic evolution both in viruses and other organisms. Stem‐loops theoretically comprise a stable part, the double‐stranded stem, and a single‐stranded loop allowing evolution. Here we tested for SARS‐CoV‐2 if “fertile” mutations were in loops while mutations in stems were poorly tolerated and rarely
Philippe Colson +5 more
wiley +1 more source
Advanced Science, Volume 12, Issue 44, November 27, 2025.High‐fidelity Nanopore sequencing offers a cost‐effective, portable path to uncovering viral dark matter in complex environments—but suffers from severe read‐length bias, low throughput, and limited accuracy. This study traces these limitations to core biochemical barriers and introduces CLAE, a foundational high‐fidelity platform that enables accurate,
Hannah Yu +14 more
wiley +1 more source
Characteristic time in quasispecies evolution [PDF]
Journal of Theoretical Biology, 2012 The time a phenotype takes to achieve a stationary state from an initial condition depends on multiple factors. In particular, it is a function of both its fitness and its mutation rate. We evaluate the average time, referred to as the characteristic time, T(c), that the system takes to reach a final steady state of simple models of populations formed ...
Sanz Nuño, Juan Carlos +3 more
openaire +4 more sources
A quasispecies on a moving oasis [PDF]
Theoretical Population Biology, 2005 A population evolving in an inhomogeneous environment will adapt differently to different regions. We study the conditions under which such a population can maintain adaptations to a particular region when that region is not stationary, but can move. In particular, we study a quasispecies living near a favorable patch ("oasis") in the middle of a large
Desai, Michael M., Nelson, David R.
openaire +4 more sources
Update on Hepatitis E Virus Infection 2025: Insights From an International Symposium
Liver International, Volume 45, Issue 11, November 2025.ABSTRACT Background and Aims The second Hepatitis E Symposium was held as an integral part of the International DFG/DZIF Joint Meeting on Viral Infections of the Liver and the Heart in Berlin. The symposium aimed to provide a comprehensive exploration of hepatitis E virus (HEV) research and bring together clinicians, basic scientists, public health ...
Lara Buchardt +11 more
wiley +1 more source
Dynamical Analysis of an HIV Infection Model Including Quiescent Cells and Immune Response
Mathematical Methods in the Applied Sciences, Volume 48, Issue 15, Page 14301-14315, October 2025.ABSTRACT This research gives a thorough examination of a human immunodeficiency virus (HIV) infection model that includes quiescent cells and immune response dynamics in the host. The model, represented by a system of ordinary differential equations, captures the complex interaction between the host's immune response and viral infection.
Ibrahim Nali +3 more
wiley +1 more source
Modeling HIV quasispecies evolutionary dynamics [PDF]
BMC Evolutionary Biology, 2007 Abstract Background During the HIV infection several quasispecies of the virus arise, which are able to use different coreceptors, in particular the CCR5 and CXCR4 coreceptors (R5 and X4 phenotypes, respectively). The switch in coreceptor usage has been correlated with a faster progression of the disease to the AIDS ...
Luca Sguanci +2 more
openaire +4 more sources
Journal of Medical Virology, Volume 97, Issue 8, August 2025.ABSTRACT Due to the continuous genetic evolution of SARS‐CoV‐2, numerous variants have emerged and different whole genome sequencing techniques, necessary for accurate virus typing, have been developed. In this study, we evaluated the performance of PacBio single‐molecule real‐time (SMRT) sequencing for SARS‐CoV‐2 typing.
Pauline Trémeaux +6 more
wiley +1 more source
Discovering Complete Quasispecies in Bacterial Genomes [PDF]
Genetics, 2017 Abstract Mobile genetic elements can be found in almost all genomes. Possibly the most common nonautonomous mobile genetic elements in bacteria are repetitive extragenic palindromic doublets forming hairpins (REPINs) that can occur hundreds of times within a genome.
Bertels, Frederic +2 more
openaire +4 more sources
Evolutionary Applications, Volume 18, Issue 8, August 2025.ABSTRACT RNA viruses often comprise multiple variants that co‐circulate in a host population, with potentially complex dynamics. Deformed wing virus (DWV), arguably the most impactful virus of honey bees (Apis mellifera), nowadays exists as two major variants, genotypes A (DWV‐A) and B (DWV‐B), which provide an amenable window into the dynamics of ...
Fernando A. Fleites‐Ayil +5 more
wiley +1 more source