Results 31 to 40 of about 95,816 (273)

In vitro catabolism of quercetin by human fecal bacteria and the antioxidant capacity of its catabolites

open access: yesFood & Nutrition Research, 2014
Background: Part of quercetin flows into the colon after escaping the absorption of the small intestine and will be degraded by colonic microbiota. The catabolites in the colon partially determine the physiological activity of quercetin.
Xichun Peng   +5 more
doaj   +1 more source

Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBPβ. [PDF]

open access: yesPLoS ONE, 2015
Quercetin is one of the most abundant polyphenolic flavonoids found in fruits and vegetables and has anti-oxidative and anti-obesity effects. Because the small intestine is a major absorptive organ of dietary nutrients, it is likely that highly ...
Makoto Shimizu   +3 more
doaj   +1 more source

The matrix metalloproteinase 7 (MMP7) links Hsp90 chaperone with acquired drug resistance and tumor metastasis

open access: yesCancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background Cancer emergence is associated with a series of cellular transformations that include acquired drug resistance followed by tumor metastasis. Matrix metalloproteinases (MMPs) and Hsp90 chaperone are implicated in tumor progression, however, they are not studied in the context of drug resistance. Aims In the present study, we aimed at
Pankaj Kumar   +2 more
wiley   +1 more source

Suppression of Intracellular Reactive Oxygen Species in Human Corneal Epithelial Cells via the Combination of Quercetin Nanoparticles and Epigallocatechin Gallate and In Situ Thermosensitive Gel Formulation for Ocular Drug Delivery

open access: yesPharmaceuticals, 2021
Oxidative stress can cause several severe ophthalmological diseases. In this study, we developed a thermosensitive gel as a delivery system for two antioxidant substances, namely, quercetin and epigallocatechin gallate.
Chuda Chittasupho   +5 more
doaj   +1 more source

Targeting Thymidylate Synthase and tRNA-Derived Non-Coding RNAs Improves Therapeutic Sensitivity in Colorectal Cancer

open access: yesAntioxidants, 2022
Some colorectal cancer (CRC) patients are resistant to 5-fluorouracil (5-FU), and high expression levels of thymidylate synthase (TS) contribute to this resistance.
Changwon Yang   +10 more
doaj   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

open access: yesAdvanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray   +2 more
wiley   +1 more source

Comparative evaluation of the postbleaching application of sodium ascorbate, alpha‐tocopherol, and quercetin on shear bond strength of composite resin to enamel

open access: yesClinical and Experimental Dental Research, Volume 8, Issue 6, Page 1598-1604, December 2022., 2022
Abstract Objective This study aimed to evaluate and compare the impacts of the postbleaching application of sodium ascorbate, alpha‐tocopherol, and quercetin on the shear bond strength (SBS) of composite resin. Material and Methods 60 extracted intact maxillary first premolars were collected and were randomly divided into five experimental groups as ...
Marzieh Moradian   +3 more
wiley   +1 more source

Genomics-guided molecular maps of coronavirus targets in human cells: a path toward the repurposing of existing drugs to mitigate the pandemic [PDF]

open access: yesarXiv, 2020
Human genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN, were employed as baits to build genomics-guided maps of up-stream regulatory elements, their expression and functions in human body, including pathophysiologically-relevant cell types.
arxiv  

Self‐Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound

open access: yesAdvanced Healthcare Materials, EarlyView.
High glucose‐ and acid‐responsive hydrogel with dynamic covalent bond solubilized with flavonoids (Gel‐Flavonoids) is designed for diabetic wound healing. The Gel‐Flavonoids adapt to irregular wound shapes and release antioxidants in high‐glucose environments, effectively reducing reactive oxygen species.
Qiang Zeng   +9 more
wiley   +1 more source

The comparative evaluation of the effects of quercetin, α‐tocopherol, and chlorhexidine dentin pretreatments on the durability of universal adhesives

open access: yesClinical and Experimental Dental Research, Volume 8, Issue 6, Page 1638-1644, December 2022., 2022
Abstract Objective The aim of this study was to evaluate and compare the effects of chlorhexidine, quercetin, and α‐tocopherol on the shear bond strength of universal adhesives in the short (24h) and long term (6 months). Material and Methods Ninety‐six extracted sound molars were collected and divided randomly into four groups: control (no treatment),
Marzieh Moradian   +3 more
wiley   +1 more source

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