Results 91 to 100 of about 18,476 (212)
Molecules, 2010 New diarylquinazolines displaying pharmaceutical potential were synthesized in high yields from 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline by using microwave-promoted regioselective Suzuki-Miyaura cross-coupling reactions.
Patrice Vanelle +3 more
doaj +1 more source
Synthesis and antibacterial activity of 2-phenyl-5-aryl-4, 5, 6, 7, 8, 9-hexahydro-1,2.4-triazolo[1,5-A]quinazolines [PDF]
, 2013 A method for the synthesis of 2-phenyl-5-aryl-4, 5, 6, 7, 8,9- hexahydrotriazolo[1,5-a] quinazolines was developed.3-Amino-5-phenyl-1,2,4-triazole formed Schiff’s bases with aromatic aldehydes which on treatment with cyclohexanonein the presence of ...
Ain Khan, Misbahul +4 more
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Synthesis and anticancer activities of diquinazoline diselenides compounds [PDF]
, 2016 A series of novel diquinazoline diselenide compounds was designed and synthesized with substituted 4-chloroquinazoline and sodium diselenide. Their structures were confirmed by IR, 1H NMR, 13C NMR, and elemental analyses.The antitumor activity of the new
Cao, Kun +6 more
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Novel Quinazoline Derivatives as Highly Effective A2A Adenosine Receptor Antagonists
MoleculesThe adenosine A2A receptor (A2AR) has been identified as a therapeutic target for treating neurodegenerative diseases and cancer. In recent years, we have highlighted the 2-aminoquinazoline heterocycle as an promising scaffold for designing new A2AR ...
Amélie Laversin +11 more
doaj +1 more source
Analgetic Activity of a Quinazoline
Experimental Biology and Medicine, 1967 SummaryFour test systems were used to demonstrate the analgetic activity of Su-13026, a quinazoline compound, in mice, rats and rabbits. Signs of central nervous system stimulation were noted. Respiration was not depressed in any of the species studied. Nalorphine did not antagonize, nor did amphetamine potentiate, the activity of this compound in mice.
H I, Chernov +4 more
openaire +2 more sources
Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth [PDF]
, 2017 Triple-negative breast cancers (TNBCs) lack the signature targets of other breast tumors, such as HER2, estrogen receptor, and progesterone receptor.
Hudmon, Andy +6 more
core +1 more source
Quinazoline compounds for antitumor treatment
Experimental Oncology, 2023 Summary. Quinazolines are among the most useful heterocyclic compounds due to their diverse chemical reactivity and a wide range of biological activity. Despite a large number of publications devoted to quinazolines and their derivatives, information is presented predominantly regarding the features of the synthesis of these compounds and their ...
openaire +2 more sources
Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives:identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1 [PDF]
, 2016 A novel series of quinazoline compounds (2-14) incorporating biologically active heterocyclic moieties were designed and synthesized. The structure of the newly synthesized compounds was recognized on the basis of elemental analyses, IR, (1)H-NMR, (13)C ...
Abdelaaty A. Shahat +9 more
core +2 more sources
Molecules, 2017 Some novel fluorinated quinazolines (5a–j) were designed and synthesized to be evaluated for their anticonvulsant activity and their neurotoxicity. Structures of all newly synthesized compounds were confirmed by their infrared (IR), mass spectrometry (MS)
Mohamed F. Zayed +5 more
doaj +1 more source