Results 21 to 30 of about 18,476 (212)

Quinazoline Based HDAC Dual Inhibitors as Potential Anti-Cancer Agents

Molecules, 2022
Cancer is the most devastating disease and second leading cause of death around the world. Despite scientific advancements in the diagnosis and treatment of cancer which can include targeted therapy, chemotherapy, endocrine therapy, immunotherapy ...
Jyothi Dhuguru, Ola A. Ghoneim
doaj   +1 more source

8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline

Chimica Techno Acta, 2020
The first example of the reaction of 5-nitro-8-hydroxyquinoline as a C-nucleophile with quinazoline is described. As a result of the reaction of C, C-coupling, a stable σ-adduct containing the drug nitroxalin on a heterocyclic carrier was obtained.
Yuri A. Azev, Olga S. Koptyaeva, Oleg S. Eltsov, Anton N. Tsmokalyuk, Tatyana A. Pospelova   +4 more
doaj   +1 more source

Medicinal Chemistry of Quinazolines as Anticancer Agents Targeting Tyrosine Kinases

Scientia Pharmaceutica, 2023
Cancer is a large group of diseases that can affect any organ or body tissue due to the abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic agents are highly toxic with a low level of selectivity.
Mohamed F. Zayed
doaj   +1 more source

Synthesis and properties of quinazoline-based versatile exciplex-forming compounds

Beilstein Journal of Organic Chemistry, 2020
Three compounds, bearing a quinazoline unit as the acceptor core and carbazole, dimethyldihydroacridine, or phenothiazine donor moieties, were designed and synthesized in two steps including a facile copper-catalyzed cyclization and a nucleophilic ...
Rasa Keruckiene, Simona Vekteryte, Ervinas Urbonas, Matas Guzauskas, Eigirdas Skuodis, Dmytro Volyniuk, Juozas V. Grazulevicius   +6 more
doaj   +1 more source

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising in vitro activity against Schistosoma mansoni. Follow-up studies of the antischistosomal potential of this candidate are presented here.
Victor Sebastian-Perez, Alfonso García-Rubia, Sayed H. Seif el-Din, Abdel-Nasser A. Sabra, Naglaa M. El-Lakkany, Samia William, Tom L. Blundell, Louis Maes, Ana Martinez, Nuria E. Campillo, Sanaa S. Botros, Carmen Gil   +11 more
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Novel 2-phenyl-3-{4’-[N-(4”-aminophenyl)carbamoyl]-phenyl}-quinazoline-4(3H)one-6-sulphonic acidbased mono azo reactive dyes [PDF]

, 2011
A series of new heterocyclic mono azo reactive dyes 7a–m were prepared by diazotization of 2-phenyl-3-{4’-[N-(4”-aminophenyl)carbamoyl]-phenyl}-quinazoline-4(3H)-one-6-sulphonic acid (3) and coupling with various cyanurated coupling components 6a–m and ...
DIVYESH R. PATEL, KESHAV C. PATEL
core   +1 more source

Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. [PDF]

, 2012
The transcription factors Elk1 and serum response factor (SRF) are central regulators of cell cycle and phenotype in various cell types. Elk1 is activated by phosphorylation (serine-383), while activation of SRF requires its co-factor, myocardin ...
Andersson, Karl-Erik, Beckmann, Christer, Füllhase, Claudius, Gratzke, Christian, Hedlund, Petter, Hennenberg, Martin, Montorsi, Francesco, Rutz, Beata, Stief, Christian Georg, Strittmatter, Frank, Waidelich, Raphaela   +10 more
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Synthesis, Characterization and Antifungal Activity of Novel Quinazolin-4-one Derivatives Containing 8-Hydroxyquinazoline Ligand and its Various Metal Complexes

E-Journal of Chemistry, 2009
Novel ligands containing quinazoline-4-one-8-hydroxyquinoline (QQ) merged moieties were prepared and characterized. For this anthranilic acid and 5-bromoanthranilic acid were converted respectively into 2-chloromethyl–3-(4-methyl phenyl)-3(H)-quinazoline-
R. T. Vashi, S. B. Patel
doaj   +1 more source

Synthesis of Lapachol and 4-Hydroxyquinazoline Derivatives as Candidates for Antimalarial Activity

Orbital: The Electronic Journal of Chemistry, 2020
Malaria is a disease that still plagues many tropical countries, affecting around 228 million people and with approximately 430 thousand deaths worldwide.
Felipe Revoredo Benatti, Keoma Keyson Lima Cavalcante, Alexandre Orsato, Carla Cristina Perez   +3 more
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Synthesis, Antibacterial, and Antioxidant Evaluation of Novel Series of Condensed Thiazoloquinazoline with Pyrido, Pyrano, and Benzol Moieties as Five- and Six-Membered Heterocycle Derivatives

Molecules, 2021
A novel synthesis of thiazolo[2,3-b]quinazolines 4(a–e), pyrido[2′,3′:4,5]thiazolo[2,3-b]quinazolines {5(a–e), 6(a–e), and 7(a–e)}, pyrano[2′,3′:4,5]thiazolo[2,3-b]quinazolines 8(a–e), and benzo[4,5]thiazolo[2,3-b]quinazoloine9(a–e) derivatives starting ...
Ebraheem Abdu Musad Saleh, Abdullah Mohammed AL Dawsari, Kakul Husain, Ismail Hassan Kutty, K.M.Lokanatha Rai   +4 more
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