Results 31 to 40 of about 18,476 (212)

New symmetrical quinazoline derivatives selectively induce apoptosis in human cancer cells [PDF]

, 2006
In the search of new symmetrical derivatives with anticancer activity, we have looked for novel compounds able to induce a selective proapoptotic mechanism in cancer cells.
Bandres, E. (Eva), Cordeu, L. (Lucía), Cubedo, E. (Elena), Font, M. (María), Garcia-Foncillas, J. (Jesús), Malumbres, R. (Raquel), Palop-Cubillo, J.A. (Juan Antonio), Rebollo, A. (Amaia), Sanmartin-Grijalba, C. (Carmen)   +8 more
core   +1 more source

Study of the Anti-klebsiella Activity of Quinazoline Compounds Containing a Piperazine Ring

Антибиотики и Химиотерапия
The aim of this study was to investigate the antimicrobial activity of piperazine ring-containing quinazoline compounds against Klebsiella pneumoniae.
A. A. Tsibizova, A. L. Yasenyavskaya, G. N. Genatullina, A. A. Ozerov, M. A. Samotrueva   +4 more
doaj   +1 more source

Quinazoline scaffold as a target for combating microbial resistance: Synthesis and antimicrobial profiling of quinazoline derivatives

Results in Chemistry
The rise of drug-resistant microbial pathogens necessitates the development of innovative antimicrobial agents. Quinazoline derivatives exhibit promising pharmacological effects and diverse chemical structures.
Vishwanath Halappanavar, Sangappa Teli, Hanamant B. Sannakki, Dharyappa Teli   +3 more
doaj   +1 more source

Synthesis and Spectral Characterization of 4,7-Dichloro-6-nitroquinazoline

Molbank, 2020
Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor (TKI) in the form of a dimaleate salt which is indicated for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC).
Thi Ngoc Nguyen, Thi Huong Tran, Nguyet Suong Huyen Dao, Van Giang Nguyen, Dinh Luyen Nguyen, Nguyen Trieu Trinh, Van Hai Nguyen   +6 more
doaj   +1 more source

Experimental, Spectroscopic, and Computational Insights into the Reactivity of “Methanal” with 2-Naphthylamines

Molecules, 2023
The reactions of 2-naphthylamine and methyl 6-amino-2-naphthoate with formalin and paraformaldehyde were studied experimentally, spectrally, and by quantum chemical calculations.
Martin Havlík, Tereza Navrátilová, Michaela Drozdová, Ameneh Tatar, Priscila A. Lanza, Diego Dusso, Elizabeth Laura Moyano, Carlos A. Chesta, Domingo Mariano A. Vera, Bohumil Dolenský   +9 more
doaj   +1 more source

Multicomponent Synthesis of Multi-Target Quinazolines Modulating Cholinesterase, Oxidative Stress, and Amyloid Aggregation Activities for the Therapy of Alzheimer's Disease. [PDF]

Molecules
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by extracellular accumulation of amyloid-beta (Aβ) peptide, intracellular neurofibrillary tangles (NFTs), severe neuronal loss, and a marked decline in cholinergic ...
Chakhari S, Marco-Contelles J, Iriepa I, Carreiras MDC, Chabchoub F, Ismaili L, Refouvelet B.   +6 more
europepmc   +2 more sources

Heterocyclic compounds with diverse biological activities: A review of quinazoline and quinazolinone derivatives

Results in Chemistry
Quinazoline and its derivative quinazolinone represent a vital class of nitrogen-containing heterocyclic compounds known for their diverse and potent biological activities.
Aditi Kalakwade, Rohini S. Kavalapure, Shankar Gharge, Shankar G. Alegaon, Shriram D. Ranade, Ling Shing Wong, Ramith Ramu   +6 more
doaj   +1 more source

Discovery of Quinazoline-2,4(1H,3H)-Dione Derivatives as Potential Antibacterial Agent: Design, Synthesis, and Their Antibacterial Activity

Molecules, 2022
In this paper, we report on the design and synthesis of a novel series of quinazoline-2,4(1H,3H)-dione derivatives as fluoroquinolone-like inhibitors of bacterial gyrase and DNA topoisomerase IV to identify and develop antimicrobial agents to prevent ...
Nader M. Boshta, Farag A. El-Essawy, Mohammed B. Alshammari, Safaa G. Noreldein, Osama M. Darwesh   +4 more
doaj   +1 more source

Lipid Pocket Binders Impose Allosteric Changes of Protein Dynamics Around the Active Site of the Protein Kinase p38α

Angewandte Chemie International Edition, EarlyView.
Used in search of novel allosteric sites in the serine/threonine kinase p38α, NMR spectroscopy reveals a dynamic coupling between the catalytic and lipid pockets. The findings uncover a motional interdependence that links distant regions of the enzyme, highlighting the lipid pocket as a promising site for allosteric intervention.
Sara Medina Gómez, Laurin T. Homberg, Mike Bührmann, Daniel Rauh, Rasmus Linser   +4 more
wiley   +1 more source

N-(2-Methylphenyl)-2-nitrobenzamide [PDF]

, 2008
In the title compound, C14H12N2O3, the dihedral angle between the two aromatic rings is 41.48 (5)°. The nitro group is twisted by 24.7 (3)° out of the plane of the aromatic ring to which it is attached.
Saeed, Aamer, Hussain, Shahid, Bolte, Michael   +2 more
core   +2 more sources