Results 61 to 70 of about 18,476 (212)

Quinazolinones as Potential Anticancer Agents: Synthesis and Action Mechanisms

Biomolecules
Quinazolinones, essential quinazoline derivatives, exhibit diverse biological activities with applications in pharmaceuticals and insecticides. Some derivatives have already been developed as commercial drugs.
Zhijiang Deng, Jieming Li, Pengbo Zhu, Jie Wang, Yuanfang Kong, Yulong Hu, Juntao Cai, Chunhong Dong   +7 more
doaj   +1 more source

Guanidine Derivatives of Quinazoline-2,4(1H,3H)-Dione as NHE-1 Inhibitors and Anti-Inflammatory Agents

Life, 2022
Quinazolines are a rich source of bioactive compounds. Previously, we showed NHE-1 inhibitory, anti-inflammatory, antiplatelet, intraocular pressure lowering, and antiglycating activity for a series of quinazoline-2,4(1H,3H)-diones and quinazoline-4(3H ...
Alexander Spasov, Alexander Ozerov, Vadim Kosolapov, Natalia Gurova, Aida Kucheryavenko, Ludmila Naumenko, Denis Babkov, Viktor Sirotenko, Alena Taran, Alexander Borisov, Elena Sokolova, Vladlen Klochkov, Darya Merezhkina, Mikhail Miroshnikov, Nadezhda Ovsyankina, Alexey Smirnov, Yulia Velikorodnaya   +16 more
doaj   +1 more source

Small Molecule Kinase Inhibitors with In Vitro β‐Hematin Formation and Plasmodium falciparum Protein Kinase G Inhibitory Activity Identified Using Machine Learning

ChemMedChem, Volume 21, Issue 3, 12 February 2026.
A random forest machine learning model was used in combination with molecular docking to predict activity of small molecule kinase inhibitors against two crucial antimalarial targets, namely hemozoin crystallization and Plasmodium falciparum protein kinase G. Derazantinib shows most promise as a dual inhibitor.
Jessica L. Thibaud, Nicolaas Salomane, Sarah Harries, Kathryn J. Wicht, Lauren B. Coulson, David Kuter, Kelly Chibale, Katherine A. de Villiers   +7 more
wiley   +1 more source

Synthesis and Anticancer Evaluation of Some Glycine Conjugated Hybrid Compounds Containing Coumarin, Thiophene and Quinazoline Moieties. [PDF]

Pharmaceuticals (Basel)
Background/Objectives: Cancer is one of the world’s leading causes of death. In 2022 alone, 9.74 million people died of cancer. It is estimated that this figure will rise to 10.4 million by 2025.
Çalışkan N, Menteşe E, Yılmaz F, İlhan S, Emirik M.   +4 more
europepmc   +2 more sources

Quinazoline derivatives: synthesis and bioactivities [PDF]

Chemistry Central Journal, 2013
Owing to the significant biological activities, quinazoline derivatives have drawn more and more attention in the synthesis and bioactivities research. This review summarizes the recent advances in the synthesis and biological activities investigations of quinazoline derivatives. According to the main method the authors adopted in their research design,
Wang, Dan, Gao, Feng
openaire   +3 more sources

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, Volume 36, Issue 16, 23 February 2026.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Structure based design and anti-breast cancer evaluation of some novel 4-anilinoquinazoline derivatives as potential epidermal growth factor receptor inhibitors

Research in Pharmaceutical Sciences, 2018
Quinazoline is one of the most widespread scaffolds amongst natural and synthetic bioactive compounds. Recently the quinazoline derivatives and in particular the 4-anilinoquinazolines have attracted much attention for their anticancer properties due to ...
Zahra Haghighijoo, Zahra Rezaei, Mansooreh Jaberipoor, Samaneh Taheri, Meysam Jani, Soghra Khabnadideh   +5 more
doaj   +1 more source

Benzothiadiazine dioxide human cytomegalovirus inhibitors: Synthesis and antiviral evaluation of main heterocycle modified derivatives [PDF]

, 2013
The benzothiadiazine dioxide derivatives are potent non-nucleoside human cytomegalovirus (HCMV) inhibitors. As part of our comprehensive structure-activity relationship (SAR) study of these compounds, we have now proposed structural modifications on the ...
Bruno, Ana M., Castro, Ana, Gil, Carmen, Martínez, Ana, Otero, Joaquín, Prieto, Columbiana, Pérez, Concepción   +6 more
core   +2 more sources

Quinazoline, Pyrazolo[1,5-c]Quinazoline and Spiro Quinazoline Dimers from the Reaction of 2-Aminoacetophenone Hydrazones with Triphosgene

Journal of Chemical Research, 2002
The reaction of hydrazones of 2-aminoacetophenone with triphosgene in dichloromethane or benzene in the presence of triethylamine gave quinazolines, pyrazolo[1,5-c]quinazoline and spiro quinazoline dimers. The latter compounds are being reported for the first time.
H. Z. Alkhathlan, M. A. Al‐Saad, H. M. Al‐Hazimi, K. A. Al‐Farhan, A. A. Mousa   +4 more
openaire   +1 more source

Integrated In Silico, In Vivo, and Deep Learning Approaches in the Discovery of Novel Candidate Molecules for Aedes aegypti Control

Archives of Insect Biochemistry and Physiology, Volume 121, Issue 2, February 2026.
An integrated computational/experimental workflow was used to identify new candidate molecules for Aedes aegypti control. Docking of 1,070 chalcones against mJHBP, followed by in vivo assays, identified 4′‐chloro‐4‐methoxychalcone (2c) as the most active larvicide candidate.
Herbert Bezerra Leite, Filipe Alves Ribeiro Rodrigues, Luana Beatriz Rocha Silva, Vanessa Costa Santos, Rosalvo F. Oliveira Neto, Edilson B. Alencar Filho   +5 more
wiley   +1 more source