Results 81 to 90 of about 18,476 (212)

Carbon-13 n.m.r. investigation on the nitrogen methylation of the mono- and diazanaphthalenes [PDF]

, 1977
The 13C n.m.r. spectra of the N-methylated mono- and diazanaphthalenes have been recorded and analysed. It has been shown that N-methylation as well as N-protonation in cinnoline occur predominantly at the -nitrogen atom.
Ham, Dirk M.W. van den, Mohan, Chandra, Weijer, Peter van de   +2 more
core   +2 more sources

Effect of Unique NNS Ligand in Manganese‐Catalyzed Transfer Hydrogenation Reaction—A DFT Mechanistic Study

ChemCatChem, Volume 18, Issue 2, 28 January 2026.
The mechanism of transfer hydrogenation between isopropanol and acetophenone based on NN‐Mn(CO)3 and NNS‐Mn(CO)2 complexes has been computed. Both complexes have similar activity under mild conditions. Isopropanol dehydrogenation represents the rate‐determining step. Transfer hydrogenation has a much lower barrier than hydrogenation using molecular H2.
Cai‐Hong Guo, Daimei Zhou, Haijun Jiao
wiley   +1 more source

Polycyclic N-Hetero Compounds. XL. Reaction of Cyclic Ketones with Trisformylaminomethane [PDF]

, 1991
Reactions of cyclic ketones such as α-tetralone, 1,3-cyclohexanedione, or naphthalenedione with formamide or trisformylaminomethane (TFAM) have shown to form polyclic fused pyrimidines by us.
Hirota, Kazuhiro, Hirota, Takashi, Iwado, Akimasa, Sasaki, Kenji   +3 more
core   +1 more source

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Synthesis of Heterocyclic Skeletons by the Reaction of N1-(2-Cyanophenyl)-benzimidoyl Chloride with Thioamides

Molecules, 2002
The reaction of N-(2-cyanophenyl)benzimidoyl chloride with reagents containing a thioamide moiety, i.e. thioacetamide, benzylthiourea, symmetrical dialkyl- and diarylthioureas gave different cyclic products: 3,1-benzothiazine, 1,3,5-benzotriazocine and ...
Pavel Pazdera, Walid M. Fathalla
doaj   +1 more source

Photoelectron spectra of fluorine substituted diazanaphthalenes: “Even cases” [PDF]

, 1975
The high resolution He 584 Å photoelectron spectra of three diazanaphthalenes and some of their fluorine derivatives are presented.
Beerlage, M., Feil, D., Ham, D.M.W. van den, Meer, D. van der   +3 more
core   +2 more sources

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, Volume 21, Issue 1, January 2026.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

Rational Design and Synthesis of a Novel Series of Thiosemicarbazone-Containing Quinazoline Derivatives as Potential VEGFR2 Inhibitors

Pharmaceutics
Background/Objectives: Angiogenesis plays a crucial role in tumor development and is a driving force for the aggressiveness of several types of cancer. Our team developed a novel series of thiosemicarbazone-containing quinazoline derivatives, TSC1-TSC10,
Alexandru Șandor, Ovidiu Crișan, Gabriel Marc, Ionel Fizeșan, Ioana Ionuț, Cristina Moldovan, Anca Stana, Ilioara Oniga, Adrian Pîrnău, Laurian Vlase, Andreea-Elena Petru, Ionuț-Valentin Creștin, Alex-Robert Jîjie, Brîndușa Tiperciuc, Ovidiu Oniga   +14 more
doaj   +1 more source

Increase of enzyme activity through specific covalent modification with fragments [PDF]

, 2017
Modulation of enzyme activity is a powerful means of probing cellular function and can be exploited for diverse applications. Here, we explore a method of enzyme activation where covalent tethering of a small molecule to an enzyme can increase catalytic ...
Adams, Anderson, Bowler, Chen, Cohen, Darby, DeSantis, DeSantis, Diaz-Rodriguez, Dixon, Elsen, Erlanson, Erlanson, Hammes, Hart, Haynes, Heinzelman, Kara, Kiick, Kintses, Li, Liao, Liese, Macauley, Macauley, Milne, Nurse, Panaretou, Perez-Miller, Roth, Sadowsky, Sanders, Sattin, Savile, Scheffzek, Stepankova, Szekrenyi, Vettoretti, Wang, Xu, Yuzwa, Yuzwa, Yuzwa, Yuzwa, Zorn   +44 more
core   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source