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A new mesoporous Ce-Mn-LDH-based Co-MOF nano-composite for the green synthesis of tetrazoloquinazolines. [PDF]
Nanoscale AdvJavadi S, Habibi D.
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Quinazolines. Part XV. Hexahydro- and octahydro-quinazolines
Journal of the Chemical Society C: Organic, 19713,4,5,6,7,8-Hexahydroquinazoline, obtained by catalytic reduction of 5,6,7,8-tetrahydroquinazoline, was slowly oxidised by air to the starting material in chloroform solution, but in aqueous alkali it was degraded to 2-formamidomethylcyclohexanone. trans-4a,5,6,7,8,8a-Hexahydroquinazolin-4(1 - or 3-H)-one was shown to be a tautomeric mixture of the (1H)
W. L. F. Armarego, Toshihiko Kobayashi
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Dermatitis from quinazoline oxide
Contact Dermatitis, 1986Dermatitis from 2‐chloromethyl‐4‐phenyl‐6‐chloroquinazoline‐3‐oxide, an intermediate product in the preparation of chlorodiazepoxide, is described in 29 workers at a pharmaceutical plant. All were patch test positive to quinazoline oxide (1%) and six to 0.05%. In most patients, the face was earlier and more severely involved than the hands.
P, Rebandel, E, Rudzki
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ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
N. N. Tonkikh +2 more
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AbstractFor Abstract see ChemInform Abstract in Full Text.
N. N. Tonkikh +2 more
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Quinazolines. Part VIII. Electronic effects in 2-substituted quinazolines
Journal of the Chemical Society C: Organic, 1966In a study of the cations of twenty 2-substituted quinazolines, it was found that covalent hydration of the 3,4-double bond decreased according to the electronic effect of the 2-substituent; viz, +l > +M > –l. This is explained by the effect of the substituent on the polarity of the C-4, N-3 double bond. The effect of the acyl group on the rate of ring
W. L. F. Armarego, J. I. C. Smith
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Pharmacology, 1971
Piquizil, a 4-aminoquinazoline causing relaxation of respiratory smooth muscle in animals, appeared to be a bronchodilator in man. A metabolite of piquizil was isolated from human urine and identified. This metabolite, named hoquizil, had a longer plasma half-time than piquizil, was generally of comparable pharmacological activity, but was better ...
M. Schach von Wittenau, T.F. Brewer
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Piquizil, a 4-aminoquinazoline causing relaxation of respiratory smooth muscle in animals, appeared to be a bronchodilator in man. A metabolite of piquizil was isolated from human urine and identified. This metabolite, named hoquizil, had a longer plasma half-time than piquizil, was generally of comparable pharmacological activity, but was better ...
M. Schach von Wittenau, T.F. Brewer
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1984
Quinazoline (1) is a building block for approximately eighty naturally occurring alkaloids isolated from a number of families of the plant kingdom, from microorganisms and from animals. The first known quinazoline alkaloid was vasicine (peganine), isolated in 1888 from Adhatoda vasica, and later from other species.
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Quinazoline (1) is a building block for approximately eighty naturally occurring alkaloids isolated from a number of families of the plant kingdom, from microorganisms and from animals. The first known quinazoline alkaloid was vasicine (peganine), isolated in 1888 from Adhatoda vasica, and later from other species.
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Tetrahedron, 1986
Abstract Grignard reagents reacted with 2-aminobenzonitrile to give the intermediate 10 , which readily could be cyclized to quinazolines by reaction with carbonyl compounds (e.g. acid chlorides, anhydrides, formates and oxalates). The intermediate 10 and aldehydes, e.g.
Jan Bergman +3 more
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Abstract Grignard reagents reacted with 2-aminobenzonitrile to give the intermediate 10 , which readily could be cyclized to quinazolines by reaction with carbonyl compounds (e.g. acid chlorides, anhydrides, formates and oxalates). The intermediate 10 and aldehydes, e.g.
Jan Bergman +3 more
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