Results 51 to 60 of about 6,888 (163)

Integrated In Silico, In Vivo, and Deep Learning Approaches in the Discovery of Novel Candidate Molecules for Aedes aegypti Control

Archives of Insect Biochemistry and Physiology, Volume 121, Issue 2, February 2026.
An integrated computational/experimental workflow was used to identify new candidate molecules for Aedes aegypti control. Docking of 1,070 chalcones against mJHBP, followed by in vivo assays, identified 4′‐chloro‐4‐methoxychalcone (2c) as the most active larvicide candidate.
Herbert Bezerra Leite, Filipe Alves Ribeiro Rodrigues, Luana Beatriz Rocha Silva, Vanessa Costa Santos, Rosalvo F. Oliveira Neto, Edilson B. Alencar Filho   +5 more
wiley   +1 more source

One-Pot Quinazolin-4-ylidenethiourea Synthesis via N-(2-Cyanophenyl)benzimidoyl isothiocyanate

Molecules, 2001
1,1-Disubstituted-3-(2-phenyl-3H-quinazolin-4-ylidene)thioureas (8) were synthesized in a one pot reaction of N-(2-cyanophenyl)benzimidoyl isothicyanate (3) with secondary amines. The products underwent transamination reactions.
Pavel Pazdera, Jaromír Marek, Michal Čajan, Walid M. Fathalla   +3 more
doaj   +1 more source

Quinazoline, Pyrazolo[1,5-c]Quinazoline and Spiro Quinazoline Dimers from the Reaction of 2-Aminoacetophenone Hydrazones with Triphosgene

Journal of Chemical Research, 2002
The reaction of hydrazones of 2-aminoacetophenone with triphosgene in dichloromethane or benzene in the presence of triethylamine gave quinazolines, pyrazolo[1,5-c]quinazoline and spiro quinazoline dimers. The latter compounds are being reported for the first time.
H. Z. Alkhathlan, M. A. Al‐Saad, H. M. Al‐Hazimi, K. A. Al‐Farhan, A. A. Mousa   +4 more
openaire   +1 more source

Nitrate Enhances Gastric Mucosa Defense and Repair Process in Ethanol‐Induced Gastric Ulcer Rats via the Notch–Tff2 Pathway

MedComm, Volume 7, Issue 2, February 2026.
Nitrate protects the three major barriers of the gastric mucosa, alleviating bleeding and inflammation of ethanol‐induced gastric ulcer in rats, and promotes migration of gastric epithelial cells, accelerating the restoration of the ulcerated epithelium, which is strongly related to TFF2, a gastric mucosal protective factor negatively regulated by the ...
Ying Liu, Xin Wen, Yuxuan Lin, Chunmei Zhang, Jinsong Wang, Guangyong Sun, Dong Zhang, Renhong Yan, Mo Chen, Songlin Wang, Shaorong Li   +10 more
wiley   +1 more source

Design, Synthesis, and Evaluation of Naphthyl Pyrazino‐Pyrido‐Pyrimidinones Targeting the Phosphoinositide 3‐Kinase/Alpha‐Serine/Protein Kinase B/Mammalian Target of Rapamycin Pathway

ChemistryOpen, Volume 15, Issue 2, February 2026.
Rationally designed naphthyl pyrazino‐pyrido‐pyrimidinones 3 and 4 inhibited 85%–94% of cancer cell growth. Compound 4 exhibited IC50 = 7.8–12.8 µM with tumor selectivity. Both induced G1 arrest and modulated ULK1, STAT3, alpha‐serine/protein kinase B (AKT), and autophagy via phosphoinositide 3‐kinase/mammalian target of rapamycin (PI3K/mTOR ...
Marcelo F. Marchiori, Gabriel da Silva, Daniel F. Kawano, Andréia M. Leopoldino, Enrique Madruga, Ana Martinez, Ivone Carvalho   +6 more
wiley   +1 more source

Antiproliferative and Antiangiogenic Properties of New VEGFR-2-targeting 2-thioxobenzo[g]quinazoline Derivatives (In Vitro)

Molecules, 2020
A series of 3-ethyl(methyl)-2-thioxo-2,3-dihydrobenzo[g]quinazolines (1–17) were synthesized, characterized, and evaluated in vitro for their antiangiogenesis VEGFR-2-targeting, antiproliferative, and antiapoptotic activities against breast MCF-7 and ...
Hatem A. Abuelizz, Mohamed Marzouk, Ahmed H. Bakheit, Hanem M. Awad, Maha M. Soltan, Ahmed M. Naglah, Rashad Al-Salahi   +6 more
doaj   +1 more source

Recent Advances in Homogeneous Catalysis with Platinum Group Pincer Complexes: Hydrogen‐Mediated Transformations and Cross‐Coupling Reactions

The Chemical Record, Volume 26, Issue 1, January 10, 2026.
Platinum group pincer complexes are highly efficient catalysts. Additionally, their high activity enables challenging transformations with low catalyst loading. Herein, we summarize the most relevant advances of catalysis involving platinum group pincer complexes. The use of pincer complexes based on platinum group metals is undoubtedly one of the most
Juan S. Serrano‐García, Andrés Amaya‐Flórez, Jordi R.‐Galindo, Adrián Ruíz‐Martínez, David Morales‐Morales   +4 more
wiley   +1 more source

Effect of Unique NNS Ligand in Manganese‐Catalyzed Transfer Hydrogenation Reaction—A DFT Mechanistic Study

ChemCatChem, Volume 18, Issue 2, 28 January 2026.
The mechanism of transfer hydrogenation between isopropanol and acetophenone based on NN‐Mn(CO)3 and NNS‐Mn(CO)2 complexes has been computed. Both complexes have similar activity under mild conditions. Isopropanol dehydrogenation represents the rate‐determining step. Transfer hydrogenation has a much lower barrier than hydrogenation using molecular H2.
Cai‐Hong Guo, Daimei Zhou, Haijun Jiao
wiley   +1 more source

Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities

Research in Pharmaceutical Sciences, 2016
The heterocyclic compounds have a great importance in medicinal chemistry. One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant ...
Elham Jafari, Marzieh Rahmani Khajouei, Farshid Hassanzadeh, Gholam Hossein Hakimelahi, Ghadam Ali Khodarahmi   +4 more
doaj  

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source