Results 121 to 130 of about 5,015,403 (283)

The kynurenine pathway: towards metabolic equilibrium [PDF]

, 2016
No abstract ...
Clarke, Gerard, Schwarcz, Robert, Stone, Trevor W.   +2 more
core   +2 more sources

The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.

PLoS ONE, 2009
Some of the tryptophan catabolites produced through the kynurenine pathway (KP), and more particularly the excitotoxin quinolinic acid (QA), are likely to play a role in the pathogenesis of Alzheimer's disease (AD).
Abdur Rahman, Kaka Ting, Karen M Cullen, Nady Braidy, Bruce J Brew, Gilles J Guillemin   +5 more
doaj   +1 more source

Manufacture of desired end products by means of fine treatment of coal tar resin [PDF]

, 2007
The possibility of desired end product manufacture from by-product coke industry wastes is shown. A large number of valuable products can be obtained from different fractions of coal tar resin by their fine treatment.
Lozbin, V. I., Mochalnikov, S. V., Nevedrov, А. V., Papin, А. V., Solodov, G. А.   +4 more
core  

Letter to the editor: autoimmune pathogenic mechanisms in Huntington’s disease [PDF]

, 2018
Letter to the Editor: Autoimmune pathogenic mechanisms in Huntington's ...
DE VINCENTIIS, Marco, De Virgilio, A, Fusconi, M, GRECO, Antonio, Inghilleri, M, Ralli, M   +5 more
core   +1 more source

Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites

EBioMedicine, 2022
Summary: Background: Neuroinflammatory diseases such as encephalitis, meningitis, multiple sclerosis and other neurological diseases with inflammatory components, have demonstrated a need for diagnostic biomarkers to define treatable and reversible ...
Jingya Yan, Velda X. Han, Benjamin Heng, Gilles J. Guillemin, Sushil Bandodkar, Russell C. Dale   +5 more
doaj  

Alpha-7 nicotinic acetylcholine receptor agonist treatment in a rat model of Huntington's disease and involvement of heme oxygenase-1

Neural Regeneration Research, 2018
Neuroinflammation is a common element involved in the pathophysiology of neurodegenerative diseases. We recently reported that repeated alpha-7 nicotinic acetylcholine receptor (α7nAChR) activations by a potent agonist such as PHA 543613 in quinolinic ...
Laura Foucault-Fruchard, Claire Tronel, Sylvie Bodard, Zuhal Gulhan, Julie Busson, Sylvie Chalon, Daniel Antier   +6 more
doaj   +1 more source

Kynurenine pathway metabolism and the microbiota-gut-brain axis [PDF]

, 2018
It has become increasingly clear that the gut microbiota influences not only gastrointestinal physiology but also central nervous system (CNS) function by modulating signalling pathways of the microbiota-gut-brain axis.
Clarke, Gerard, Cryan, John F., Dinan, Timothy G., Kennedy, Paul J.   +3 more
core   +1 more source

Specific Reactions of Different Striatal Neuron Types in Morphology Induced by Quinolinic Acid in Rats

PLoS ONE, 2014
Huntington's disease (HD) is a neurological degenerative disease and quinolinic acid (QA) has been used to establish HD model in animals through the mechanism of excitotoxicity.
Qiqi Feng, Yuxin Ma, Shuhua Mu, Jiajia Wu, Si Chen, Lisi Ouyang, W. Lei   +6 more
semanticscholar   +1 more source

Kynurenine pathway metabolites selectively associate with impaired associative memory function in depression

Brain, Behavior, & Immunity - Health, 2020
Activation of the kynurenine pathway (KP), an important downstream effect of inflammation, is a driver of depression and neurodegeneration. Damage from the end product of KP activation, quinolinic acid, may be responsible specifically for impairment in ...
Margherita Chirico, James Custer, Ifeoluwa Shoyombo, Crystal Cooper, Sheila Meldrum, Robert Dantzer, Madhukar H. Trivedi, Paul Rathouz, Marisa S. Toups   +8 more
doaj  

Factors in AIDS dementia complex trial design: Results and lessons from the abacavir trial [PDF]

, 2007
OBJECTIVES: To determine the efficacy of adding abacavir (Ziagen, ABC) to optimal stable background antiretroviral therapy (SBG) to AIDS dementia complex (ADC) patients and address trial design.
Arthur, Justin C. Mc, Atkinson, Hamp, Brew, Bruce J, Brown, Steve, Catalan, Jose, Clifford, David B, Hall, Colin, Halman, Mark, Marder, Karen, Power, Christopher, Price, Richard W, Romero, Carmen, Sacktor, Ned, Simpson, David, Symonds, William, Torres, Gabriel   +15 more
core   +4 more sources